Rchr
J-GLOBAL ID：201801008867488765   Update date: Feb. 01, 2024

Hiroshi Ueno

ウエノ ヒロシ | Hiroshi Ueno
Affiliation and department：
The University of Tokyo The Graduate School of Engineering, Department of Applied Chemistry

About The University of Tokyo The Graduate School of Engineering, Department of Applied Chemistry


Research field  (1)： Biophysics
Research keywords  (5)： 生物物理学 ,  ATP合成酵素 ,  デジタルバイオ分析 ,  分子モーター ,  1分子計測
Research theme for competitive and other funds  (9)：
  • 2023 - 2025 Elucidation of the evolution of the rotary catalysis mechanism of F1-ATPase by reconstruction of the ancestral enzyme
  • 2021 - 2023 新規on-chipスクリーニング技術による分子機械の機能改変
  • 2019 - 2021 生体分子の改造・創成を実現する新規進化分子工学的スクリーニング技術の開発
  • 2018 - 2020 酵素1分子の活性揺らぎと進化能の関係
  • 2016 - 2019 Elucidation of rotary ion transport mechanism of V-ATPase by visualization and control of substrate
Show all
Papers (60)：
  • Hiroshi Ueno, Mio Sano, Mayu Hara, Hiroyuki Noji. Digital Cascade Assays for ADP- or ATP-Producing Enzymes Using a Femtoliter Reactor Array Device. ACS sensors. 2023. 8. 9. 3400-3407
  • Ryo R Watanabe, Busra Tas Kiper, Mariel Zarco-Zavala, Mayu Hara, Ryohei Kobayashi, Hiroshi Ueno, José J García-Trejo, Chun-Biu Li, Hiroyuki Noji. Rotary properties of hybrid F1-ATPases consisting of subunits from different species. iScience. 2023. 26. 5. 106626-106626
  • Ryohei Kobayashi, Hiroshi Ueno, Kei-Ichi Okazaki, Hiroyuki Noji. Molecular mechanism on forcible ejection of ATPase inhibitory factor 1 from mitochondrial ATP synthase. Nature communications. 2023. 14. 1. 1682-1682
  • Morito Sakuma, Shingo Honda, Hiroshi Ueno, Kazuhito Tabata, Kentaro Miyazaki, Nobuhiko Tokuriki, Hiroyuki Noji. Genetic Perturbation Alters Functional Substates in Alkaline Phosphatase. Journal of the American Chemical Society. 2023. 145. 5. 2806-2814
  • Yuh Hasimoto, Mitsuhiro Sugawa, Yoshihiro Nishiguchi, Fumihiro Aeba, Ayari Tagawa, Kenta Suga, Nobukiyo Tanaka, Hiroshi Ueno, Hiroki Yamashita, Ryuichi Yokota, et al. Direct identification of the rotary angle of ATP cleavage in F1-ATPase from Bacillus PS3. Biophysical journal. 2022
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MISC (64)：
  • 鈴木綾, 上野博史, 黒崎涼, 内橋貴之, 野地博行. 病原性大腸菌EPECが有するIII型分泌装置のATPase複合体の機能解析. 日本蛋白質科学会年会プログラム・要旨集. 2021. 21st
  • 田口真衣, 上野博史, 野地博行. In vitro synthesis of F1-ATPase and construction of single molecule rotation assay system for cell-free screening. 日本生体エネルギー研究会討論会講演要旨集. 2021. 47th (CD-ROM)
  • 小林稜平, 上野博史, 野地博行. Molecular basis of the unidirectional regulation on ATPase inhibitory factor 1 (IF1) in mitochondrial ATP synthase. 日本生体エネルギー研究会討論会講演要旨集. 2021. 47th (CD-ROM)
  • 渡邉亮, 上野博史, 鈴木俊治, 小林稜平, 野地博行. 異種由来のサブユニットを持つハイブリッドF1-ATPaseの1分子回転観察. 生体分子科学討論会講演要旨集. 2019. 46th
  • 野地 博行, 上野 博史. 回転分子モーターF1-ATPaseの回転特性とエンジニアリング的アプローチ (特集 動け!高分子). 高分子 = High polymers, Japan : polymers. 2018. 67. 6. 321-323
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Patents (2)：
Lectures and oral presentations  (5)：
  • Engineering approaches to understanding the unidirectional regulatory function of F1-ATPase
    (2022 East Asian Single-Molecule Biophysics Symposium (EASMB 2022) 2022)
  • 全反射型暗視野顕微鏡による 生体分子モーターの 1 分子イメージング
    (ニコンWebセミナー 全反射蛍光顕微鏡 (TIRF)セミナー 2022)
  • Digital bioassays and digital gene expression for screening
    (The 2nd Conference on Biomotors, Virus Assembly, and Nanobiotechnology Applications 2019)
  • Intrinsic diversities of catalytic activity among single enzyme molecules and virus particles revealed with femtoliter reactor array
    (Joint meeting of the 10th International Forum on Post-Genomic Technology and the 11th International Workshop on Approaches to Single-Cell Analysis 2018)
  • Rotation mechanisms of rotary ATPases
    (Complex systems and Biological physics seminar 2018)
Education (3)：
  • 2002 - 2005 Tokyo Institute of Technology Interdisciplinary Graduate School of Science and Engineering
  • 2000 - 2002 Tokyo Institute of Technology Interdisciplinary Graduate School of Science and Engineering
  • 1996 - 2000 Tokyo Institute of Technology School of Bioscience and Biotechnology
Professional career (1)：
  • 博士(理学) (東京工業大学)
Work history (3)：
  • 2022/04 - 現在 The University of Tokyo The Graduate School of Engineering, Department of Applied Chemistry
  • 2015/02 - 2022/03 The University of Tokyo
  • 2011/04 - 2015/01 Chuo University Faculty of Science and Engineering Department of Physics
Association Membership(s) (1)：
日本生物物理学会
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