Shinohara Kyosuke

Affiliation and department：
Job title： Associate Professor

Research field (1)： Cell biology

Research theme for competitive and other funds (10)：

2021 - 2026 哺乳類の気道繊毛細胞がジオラマ環境変動に応答する際の原生知能の解明
2021 - 2026 Ethological dynamics to formulate proto-intelligence exerted in diorama environments.
2019 - 2021 微小管結合蛋白質の意外な機能:繊毛細胞の脂質を酸化から守る原理の解明
2018 - 2019 細胞夾雑系における脱凝集因子Hsp104の特性解析と神経変性疾患治療への応用
2017 - 2019 繊毛運動を支える組みひも状アクチンナノブレイドの機能構造解析

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Papers (43)：

Yosuke Inoue, Yuya Hanazono, Kentaro Noi, Akihiro Kawamoto, Masato Kimatsuka, Ryuhei Harada, Kazuki Takeda, Ryoichi Kita, Natsuki Iwamasa, Kyoka Shibata, et al. Split conformation of Chaetomium thermophilum Hsp104 disaggregase. Structure. 2021. 29. 7. 721-730.e6
Kazuaki Hakamada, Manami Nakamura, Rio Midorikawa, Kyosuke Shinohara, Keiichi Noguchi, Hikaru Nagaoka, Eizo Takashima, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, et al. PV1 Protein from Plasmodium falciparum Exhibits Chaperone-Like Functions and Cooperates with Hsp100s. International Journal of Molecular Sciences. 2020. 21. 22. 8616-8616
Hiroshi Yoke, Hironori Ueno, Akihiro Narita, Takafumi Sakai, Kahoru Horiuchi, Chikako Shingyoji, Hiroshi Hamada, Kyosuke Shinohara. Rsph4a is essential for the triplet radial spoke head assembly of the mouse motile cilia. PLoS Genetics. 2020. 16. 3. e1008664-e1008664
Yohda Masafumi, Inoue Yosuke, Hanazono Yuya, Noi Kentaro, Kawamoto Akihiro, Takeda Kazuki, Noguchi Keiichi, Namba Keiichi, Ogura Teru, Miki Kunio, et al. TRANSIENT SPLITTING OF HSP104 HEXAMERIC RING AND ITS IMPLICATION IN PROTEIN DISAGGREGATION. PROTEIN SCIENCE. 2019. 28. 22
Morita Kento, Yamamoto Yohei Y, Hori Ayaka, Obata Tomohiro, Uno Yuko, Shinohara Kyosuke, Noguchi Keiichi, Noi Kentaro, Ogura Teru, Ishii Kentaro, et al. Expression, Functional Characterization, and Preliminary Crystallization of the Cochaperone Prefoldin from the Thermophilic Fungus Chaetomium thermophilum. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2018. 19. 8

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MISC (19)：

野井健太郎, 柴田京華, 小椋光, 養王田正文, 篠原恭介. アミロイド線維に対するHsp104の脱凝集活性の機能解析. 日本蛋白質科学会年会プログラム・要旨集. 2023. 23rd (CD-ROM)
野井健太郎, 柴田京華, 小椋光, 養王田正文, 篠原恭介. Hsp104によるα-シヌクレインのアミロイド線維の脱凝集活性の機能解析. 日本生化学会大会(Web). 2023. 96th
野井健太郎, 柴田京香, 小椋光, 養王田正文, 篠原恭介. 分子シャペロンHsp104によるアミロイド線維分解機構の動的解析. 日本臨床ストレス応答学会大会抄録集. 2022. 16th
野井健太郎, 柴田京華, 小椋光, 養王田正文, 篠原恭介. 高速AFMを用いたHsp104によるアミロイド線維脱凝集の動的解析. 日本生化学会大会(Web). 2022. 95th
Toshihiro Omori, Kyosuke Shinohara, Hiroshi Hamada, Takuji Ishikawa. Computational study of the nodal flow with a small number of cilia: comparison of mechanosensing and vesicle transport hypotheses. 8th World Congress of Biomechanics. 2018. O0636

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Professional career (1)：

博士(工学) (東京大学)

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