Rchr
J-GLOBAL ID:201801013675227686   Update date: Nov. 06, 2024

OHARA TOSHIAKI

オオハラ トシアキ | OHARA TOSHIAKI
Affiliation and department:
Research field  (1): Clinical pharmacy
Research theme for competitive and other funds  (33):
  • 2024 - 2028 Validation of Tumor Immune Remodeling Effects of CAF Targeted Therapy in ICI Resistance
  • 2024 - 2027 数理モデルを用いた開心術後外科的糖尿病におけるインスリン抵抗性の機序の解明
  • 2024 - 2027 歯周病による腸内の鉄代謝異常が大腸癌の進行に与える影響の解明
  • 2023 - 2027 A Novel Mechanism of Infertility through the Oral-Uterine Interaction Induced by Periodontal Infection and Inflammation
  • 2024 - 2027 The study of novel targets for infertility, with a focus on the link between oral disease (periodontal disease) and the uterus.
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Papers (102):
  • Shinichi Kawana, Mikio Okazaki, Tomohisa Sakaue, Kohei Hashimoto, Kentaro Nakata, Haruki Choshi, Shin Tanaka, Kentaroh Miyoshi, Shinji Ohtani, Toshiaki Ohara, et al. Loss of Nr4a1 ameliorates endothelial cell injury and vascular leakage in lung transplantation from circulatory-death donor. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2024
  • Yuze Wang, Aye Moh-Moh-Aung, Tianyi Wang, Masayoshi Fujisawa, Toshiaki Ohara, Ken-Ichi Yamamoto, Masakiyo Sakaguchi, Teizo Yoshimura, Akihiro Matsukawa. Exosomal delivery of miR-200b-3p suppresses the growth of hepatocellular carcinoma cells by targeting ERG- and VEGF-mediated angiogenesis. Gene. 2024. 148874-148874
  • Kobayashi, T., Noma, K., Nishimura, S., Kato, T., Nishiwaki, N., Ohara, T., Kunitomo, T., Kawasaki, K., Akai, M., Komoto, S., et al. Near-infrared Photoimmunotherapy Targeting Cancer-Associated Fibroblasts in Patient-Derived Xenografts Using a Humanized Anti-Fibroblast Activation Protein Antibody. Molecular Cancer Therapeutics. 2024. 23. 7
  • Motoyasu Tabuchi, Satoru Kikuchi, Hiroshi Tazawa, Tomohiro Okura, Toshihiro Ogawa, Ema Mitsui, Yuta Une, Shinji Kuroda, Hiroki Sato, Kazuhiro Noma, et al. Functional remodeling of intraperitoneal macrophages by oncolytic adenovirus restores anti-tumor immunity for peritoneal metastasis of gastric cancer. Molecular therapy. Oncology. 2024. 32. 2. 200806-200806
  • Tianyi Wang, Tong Gao, Masayoshi Fujisawa, Toshiaki Ohara, Masakiyo Sakaguchi, Teizo Yoshimura, Akihiro Matsukawa. SPRED2 Is a Novel Regulator of Autophagy in Hepatocellular Carcinoma Cells and Normal Hepatocytes. International journal of molecular sciences. 2024. 25. 11
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MISC (376):
  • 杉山 友康, 藤澤 真義, 土井 晃一郎, 亀田 弘之, 笠井 智成, 大原 利章. 癌の血管走行を深層学習した人工知能の開発. 日本生物工学会大会講演要旨集. 2024. 2024年. 82-82
  • 王 天一, 高 桐, 藤澤 真義, 大原 利章, 吉村 禎造, 松川 昭博. SPRED2の欠損はマウスの腫瘍においてオートファジーとマイトファジーを抑制する(SPRED2 deficiency downregulates autophagy and mitophagy in tumors in cancer-bearing mouse model). 日本病理学会会誌. 2024. 113. 1. 298-298
  • 陳 悦華, 大原 利章, 王 宇沢, 浜田 祐輔, 藤澤 真義, 松川 昭博. 鉄キレート効果を持つHIF-PH阻害薬は抗腫瘍免疫応答を向上させる(Pseudo-hypoxia by iron chelator arguments the tumor immune response against MSS colorectal cancer). 日本病理学会会誌. 2024. 113. 1. 311-311
  • 藤澤 真義, 大原 利章, 樋口 拓浩, 松川 昭博. AIを用いた組織切片厚の推定法の開発. 日本病理学会会誌. 2024. 113. 1. 314-314
  • 高 桐, テン・ミャオ, 藤澤 真義, 大原 利章, 王 天一, トウン・ニンテインダ, 李 春寧, 吉村 禎造, 松川 昭博. SPRED2制御したexosomeは、がん細胞においてmacrophageの極性化を促進し、IL6-STAT3シグナルを活性化する(Exosome regulated by SPRED2, promotes macrophage polarization and activate IL6-STAT3 signaling). 日本病理学会会誌. 2024. 113. 1. 324-324
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Patents (20):
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Books (4):
  • Development of a wood compression technology to enhance the efficiency of woody biomass fuel production.
    Clean energy 2023
  • Roller compaction method for the production of high-quality woody biomass fuel.
    2023
  • Management of dialysis operations for safety assurance and (2) Implementation of AI-based dialysis room management
    2021
  • Challenging the Next-Generation Life Innovations: Development of Novel Cancer Therapies Using Iron Removal Application.
    2014
Work history (4):
  • 2024/09 - 現在 Okayama University Faculty of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Pathology & Experimental Medicine
  • 2014/05 - 現在 Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Pathology and Experimental Medicine Assistant Professor
  • 2012/04 - 2014/05 Okayama University Graduate School of Medicine , Dentistry and Pharmaceutical Sciences
  • 2002/04 - 2002/07 Okayama University Medical School
Committee career (2):
  • 2023/09 - 2023/09 The 47th Annual Congress of Japanese Bioiron Society Congress President
  • 2022/10 - 2023/05 Cancers Guest editor Special Issue "The Impact of Iron Metabolism in Cancer"
Awards (5):
  • 2023/05 - The Sanyo Broadcasting Foundation Research Award
  • 2020/10 - Ryobi Teien Memory Foundation Research Award
  • 2014/11 - Japanese Society for Gastroenterological Carcinogenesis Young Investigator Award
  • 2014/06 - Okayama Medical Association Incentive Award
  • 2014/02 - Princess Takamatsu Cancer Research Fund Prizes Research Grants
Association Membership(s) (10):
Japanese Association for Medical Artificial Intelligence ,  THE JAPAN ESOPHAGEAL SOCIETY ,  Japanese Society for Gastroenterological Carcinogenesis ,  American Society of Clinical Oncology ,  American Association for Cancer Research ,  The Japanese BioIron society ,  The Japanese Cancer Association ,  The Japanese Society of Gastroenterological Surgery ,  Japan Surgical Society ,  The Japanese Society of Pathology
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