Takenaka Nobuyuki

Affiliation and department：
Homepage URL (1)： https://cms.omu.ac.jp/tkysato/

Research field (2)： Molecular biology , Cell biology

Research keywords (1)：骨格筋、脂肪細胞、白色脂肪細胞、褐色脂肪細胞、Rac1、GLUT4、CD36、FATP1、低分子量GTP結合タンパク質、グルコース取込み、脂肪酸、インスリン、肥満、糖尿病、NAFLD、脂肪肝、細胞内シグナル伝達、肝臓、ノックアウトマウス

Research theme for competitive and other funds (6)：

2020 - 2023 白色脂肪細胞の分化と肥大化の新規制御機構とその破綻による病態の解明
2019 - 2022 Elucidation of the molecular mechanism for triacylglycerol storage in white adipocytes and the mechanism of fatty liver and type 2 diabetes due to its disruption
2017 - 2020 Elucidation of a novel insulin signaling pathway in adipocytes
2014 - 2017 Nobel signaling mechanisms for insulin-dependent glucose uptake in skeletal muscle
2012 - 2014 Analysis of signaling mechanisms for cellular response to low temperature in mammals

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Papers (22)：

Kiko Hasegawa, Nobuyuki Takenaka, Kenya Tanida, Man Piu Chan, Mizuki Sakata, Atsu Aiba, Takaya Satoh. Atrophy of White Adipose Tissue Accompanied with Decreased Insulin-Stimulated Glucose Uptake in Mice Lacking the Small GTPase Rac1 Specifically in Adipocytes. International journal of molecular sciences. 2021. 22. 19
Nobuyuki Takenaka, Mika Nakao, Kiko Hasegawa, Man Piu Chan, Takaya Satoh. The guanine nucleotide exchange factor FLJ00068 activates Rac1 in adipocyte insulin signaling. FEBS letters. 2020. 594. 24. 4370-4380
Nobuyuki Takenaka, Mika Nakao, Sayaka Matsui, Takaya Satoh. A Crucial Role for the Small GTPase Rac1 Downstream of the Protein Kinase Akt2 in Insulin Signaling that Regulates Glucose Uptake in Mouse Adipocytes. International journal of molecular sciences. 2019. 20. 21
Nobuyuki Takenaka, Natsumi Araki, Takaya Satoh. Involvement of the protein kinase Akt2 in insulin-stimulated Rac1 activation leading to glucose uptake in mouse skeletal muscle. PloS one. 2019. 14. 2. e0212219
Nobuyuki Takenaka, Yuma Nihata, Sho Ueda, Takaya Satoh. In situ detection of the activation of Racl and RalA small GTPases in mouse adipocytes by immunofluorescent microscopy following in vivo and ex vivo insulin stimulation. CELLULAR SIGNALLING. 2017. 39. 108-117

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MISC (3)：

岡本成史, 竹中延之, 迫田義博, 岡松正敏, 山本直樹, ハリディアーマド, 山田博司, 森康子, 喜田宏, 山西弘一. パンデミックインフルエンザの発生に即応した,ワクチン製造用種ウイルス株の作出-インフルエンザウイルスライブラリーの利用-. 日本ウイルス学会学術集会プログラム・抄録集. 2012. 60th. 263
OKAMOTO SHIGEFUMI, TANIMOTO TAKESHI, TAKANO DAISUKE, MATSUOKA SUMIKO, HAREDY AHMAD, TAKENAKA NOBUYUKI, TAMURA SHIN'ICHI, OKUNO YOSHINOBU, MORI YASUKO, YAMANISHI KOICHI. 抗インフルエンザIgAモノクローナル抗体による交叉防御効果の可能性. 日本ワクチン学会学術集会プログラム・抄録集. 2011. 15th. 84
H. Edamatsu, N. Takenaka, T. Kataoka. OVEREXPRESSION OF PHOSPHOLIPASE C EPSILON IN KERATINOCYTES RESULTS IN IL-23 PRODUCTION LEADING TO SKIN INFLAMMATION ACCOMPANIED BY IL-22-PRODUCING T CELL INFILTRATION. INFLAMMATION RESEARCH. 2011. 60. 61-61

Patents (2)：

Professional career (1)：

Association Membership(s) (2)：

日本生化学会 , 日本分子生物学会

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