Ueda Keisuke

ウエダケイスケ | Ueda Keisuke

Affiliation and department：
Homepage URL (1)： http://www.p.chiba-u.jp/lab/seizai/index.html

Research field (1)： Pharmaceuticals - analytical and physicochemistry

Research keywords (10)： LLPS , LNP , lipid formulations , nanoemulsion , ナノ粒子 , 固体分散体 , 固体NMR , NMR , 物理薬剤 , 分子製剤学

Research theme for competitive and other funds (17)：

2024 - 2028 Elucidation of destabilization mechanism of drug amorphous nanosuspension for middle-molecule drug development
2022 - 2025 Development of drug-rich phase-coexisting lipid nanoparticle formulations based on elucidation of molecular mechanism of liquid-liquid phase separation phenomenon of drugs
2021 - 2024 Structural evaluation of solid-liquid interface of drug nanoamorphous by suspended-state NMR
2020 - 2023 Drug dissolution mechanism based on evaluation of polymer structure, mobility, and intermolecular interaction
2023 - NMR及び液中AFMを用いたmRNA封入脂質ナノ粒子製剤品質評価技術の開発

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Papers (92)：

Keisuke Ueda, Yui Sakagawa, Tomoki Saito, Fumie Sakuma, Hiroki Tanaka, Hidetaka Akita, Kenjirou Higashi, Kunikazu Moribe. NMR-based analysis of impact of siRNA mixing conditions on internal structure of siRNA-loaded LNP. Journal of controlled release : official journal of the Controlled Release Society. 2024. 373. 738-748
Fumie Sakuma, Kenjirou Higashi, Keisuke Ueda, Takeshi Morita, Daisuke Iohara, Fumitoshi Hirayama, Kunikazu Moribe. Effect of Acetaminophen on Poloxamer 407 Micelles and Hydrogels: The Relationship between Structural and Physical Properties. Langmuir. 2024
Keisuke Ueda. Voices in Molecular Pharmaceutics: Meet Professor Keisuke Ueda, Who Scrutinizes the Molecular-Level Properties of Drugs and Formulations Using NMR Spectroscopy. Molecular pharmaceutics. 2024
Etsushi Yoshikawa, Keisuke Ueda, Rei Hakata, Kenjirou Higashi, Kunikazu Moribe. Quantitative Investigation of Intestinal Drug Absorption Enhancement by Drug-Rich Nanodroplets Generated via Liquid-Liquid Phase Separation. Molecular pharmaceutics. 2024. 21. 4. 1745-1755
Yushi Sunazuka, Keisuke Ueda, Kenjirou Higashi, Koichi Wada, Kunikazu Moribe. Mechanistic Analysis of Temperature-Dependent Curcumin Release from Poly(lactic-co-glycolic acid)/Poly(lactic acid) Polymer Nanoparticles. Molecular pharmaceutics. 2024. 21. 3. 1424-1435

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MISC (19)：

植田圭祐, 金子舜, 東顕二郎, 森部久仁一. Thermodynamic analysis of effect of a second drug on amorphous solubility of ritonavir. 日本薬学会年会要旨集(Web). 2024. 144th
藤本泰輝, 植田圭祐, 東顕二郎, 森部久仁一. リポソームへのdoxorubicin封入率にPEG修飾が及ぼす影響の評価. KEK Proceedings (Web). 2024. 2024-2
喜田浩平, 植田圭祐, 東顕二郎, 森部久仁一. Evaluation of mechanical property of irinotecan-loaded liposomes using atomic force microscopy. 日本薬学会年会要旨集(Web). 2024. 144th
関優太, 植田圭祐, 東顕二郎, 森部久仁一. Drug encapsulation into lipid/γ-cyclodextrin thermoresponsive nanoparticles. 日本薬学会年会要旨集(Web). 2024. 144th
藤本泰輝, 植田圭祐, 東顕二郎, 森部久仁一. Mechanistic investigation of morphological changes of doxorubicin-loaded liposomes by PEG modification. 日本薬学会年会要旨集(Web). 2024. 144th

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Patents (4)：

Books (27)：

【医薬品の原薬・添加剤の安定供給と最新技術】添加剤による難水溶性薬物の溶解性改善基礎理論と最近の研究紹介
(株)じほう 2023
結晶状態の評価法-Evaluation Methodology for Crystalline State of Drug Substance-製剤試験特集
東京 : 製剤機械技術学会 2023
液-液相分離現象を活用した超難溶性薬物の経口製剤化
東京 : 上原記念生命科学財団 2023
Evaluation Methodology for Crystalline State of Drug Substance
2023
Solubility improvement of poorly water-soluble drugs by additives~basic theory and introduction of recent study~
2023

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Lectures and oral presentations (196)：

Thermodynamic analysis of effect of a second drug on amorphous solubility of ritonavir
(日本薬学会年会要旨集(Web) 2024)
リポソームへのdoxorubicin封入率にPEG修飾が及ぼす影響の評価
(KEK Proceedings (Web) 2024)
Evaluation of mechanical property of irinotecan-loaded liposomes using atomic force microscopy
(日本薬学会年会要旨集(Web) 2024)
Drug encapsulation into lipid/γ-cyclodextrin thermoresponsive nanoparticles
(日本薬学会年会要旨集(Web) 2024)
Mechanistic investigation of morphological changes of doxorubicin-loaded liposomes by PEG modification
(日本薬学会年会要旨集(Web) 2024)

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Professional career (1)：

Work history (3)：

2015/04 - 現在 Chiba University Graduate School of Pharmaceutical Sciences Assistant Professor
2019/06 - 2020/03 Purdue University Department of Industrial and Physical Pharmacy IPPH
2014/04 - 2015/03 Japan Society for the Promotion of Science Research Fellowship for Young Scientists

Committee career (7)：

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Awards (9)：

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