Research theme for competitive and other funds (7)：
2022 - 2025 急性腎障害後の尿細管の再生機構破綻におけるCD44の役割解明
2019 - 2022 薬剤性急性腎障害から慢性腎臓病への進展を予測する新規評価分子の探索
2019 - 2022 腸管粘膜バリア破綻条件下での高分子化合物の経口暴露による毒性影響の解明
2019 - 2022 The role of regenerative tubules in progression from acute kidney injury to chronic kidney disease
2018 - 2021 レポーター遺伝子導入動物を用いたクロロプロパノール類の発がん機序の解明
2018 - 2021 OECDプログラムにおいてTGとDAを開発するためのAOPに関する研究
2015 - 2017 AOPおよびIATAに立脚した国際的な安全性評価手法の確立
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Papers (53)：
Kohei Matsushita, Takeshi Toyoda, Hirotoshi Akane, Tomomi Morikawa, Kumiko Ogawa. CD44 expression in renal tubular epithelial cells in the kidneys of rats with cyclosporine-induced chronic kidney disease. Journal of toxicologic pathology. 2024. 37. 2. 55-67
Hirotoshi Akane, Takeshi Toyoda, Kohei Matsushita, Tomomi Morikawa, Tadashi Kosaka, Hitoshi Tajima, Hiroaki Aoyama, Kumiko Ogawa. Comparison of the sensitivity of histopathological and immunohistochemical analyses and blood hormone levels for early detection of antithyroid effects in rats treated with thyroid peroxidase inhibitors. Journal of Applied Toxicology. 2024. 44. 7. 1084-1103
Kohei Matsushita, Takeshi Toyoda, Hirotoshi Akane, Tomomi Morikawa, Kumiko Ogawa. Role of CD44 expressed in renal tubules during maladaptive repair in renal fibrogenesis in an allopurinol-induced rat model of chronic kidney disease. Journal of applied toxicology : JAT. 2024. 44. 3. 455-469
Ken Kuroda, Yuji Ishii, Shinji Takasu, Aki Kijima, Kohei Matsushita, Ken-Ichi Masumura, Takehiko Nohmi, Takashi Umemura. Possible contribution of 8-hydroxydeoxyguanosine to gene mutations in the kidney DNA of gpt delta rats following potassium bromate treatment. Mutation research. Genetic toxicology and environmental mutagenesis. 2024. 894. 503729-503729
Takeshi Toyoda, Takuma Kobayashi, Noriyuki Miyoshi, Kohei Matsushita, Hirotoshi Akane, Tomomi Morikawa, Kumiko Ogawa. Mucosal damage and γ-H2AX formation in the rat urinary bladder induced by aromatic amines with structures similar to o-toluidine and o-anisidine. Archives of toxicology. 2023. 97. 12. 3197-3207
松下幸平, 豊田武士, 赤根弘敏, 森川朋美, 小川久美子. Morphology and CD44 expression in renal tubules of rats with cyclosporine-induced renal fibrosis. 日本毒性病理学会総会及び学術集会講演要旨集. 2024. 40th
豊田武士, 松下幸平, 赤根弘敏, 畝山瑞穂, 森川朋美, 小川久美子. Early detection of renal carcinogens by γ-H2AX immunostaining in rats. 日本毒性病理学会総会及び学術集会講演要旨集. 2024. 40th
赤根弘敏, 豊田武士, 松下幸平, 畝山瑞穂, 森川朋美, 小坂忠司, 田島均, 青山博昭, 小川久美子. Pathological analysis and hormone levels in the detection of antithyroid effects of TSH synthesis inhibitors in rats. 日本毒性病理学会総会及び学術集会講演要旨集. 2024. 40th
2018/04 - 2023/08 National Institute of Health Sciences Division of Pathology Senior Researcher
2016/03 - 2018/03 National Institute of Health Sciences Division of Pathology Researcher
2008/04 - 2016/02 Otsuka Pharmaceutical Co. Ltd. Safety Research Center
Committee career (6)：
2024/04 - 現在 内閣府食品安全委員会 農薬専門調査会 専門委員
2024/04 - 現在 日本毒性病理学会 評議員
2021/04 - 現在 日本獣医病理学専門家協会 評議員
2019/09 - 現在 独立行政法人医薬品医療機器総合機構 専門委員
2019/08 - 現在 厚生労働省 化審法GLP査察専門家
2019/02 - 現在 厚生労働省 安衛法GLP査察専門家
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Awards (6)：
2020/02 - 第36回日本毒性病理学会学術集会 年会長賞
2020/01 - 第2回医薬品毒性機序研究会 若手優秀発表賞
2015/03 - Japanese Society of Veterinary Pathology Encouragement award
2014/01 - Japanese Society of Toxicologic Pathology Encouragement award
2013/06 - Japanese Society of Toxicology Best Presentation Award
2013/02 - The 4th Joint Workshop of Seoul University, Gifu University, and Yamaguchi University The excellent presentation award (oral)
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Association Membership(s) (5)：
THE JAPANESE SOCIETY OF VETERINARY SCIENCE
, Japanese College of Veterinary Pathologists
, THE JAPANESE SOCIETY OF TOXICOLOGY
, Japanese Society of Toxicologic Pathology
, 日本腎臓学会
