Nakagami Hironori

ナカガミヒロノリ | Nakagami Hironori

Affiliation and department：

Research field (1)： Internal medicine - General

Research theme for competitive and other funds (37)：

2022 - 2025 動脈硬化発症プロセスにおける一酸化窒素修飾がもたらすエンドセリン受容体機能の検討
2022 - 2025 Metabolomics analysis of plasma and exosomes for frailty biomarkers
2022 - 2025 高齢者のCOVID-19感染リスクを安全に低下し得る新規戦略の開発
2022 - 2025 認知症関連病的蛋白の翻訳後修飾を標的としたワクチン療法の開発
2021 - 2025 タウ病理の脳内進展過程を標的とした認知症の層別化・個別化治療に向けた基盤的研究

2021 - 2024 Pathological involvement of endothelial alpha synuclein in age-related insulin resistance

2021 - 2024 Therapeutic vaccine for senolysis

2020 - 2023 糖尿病網膜症の発症予防のためのワクチン治療の開発と新規糖尿病網膜症モデルの確立

2020 - 2023 部分再開通における脳梗塞進展の機序解明と治療法の開発

2020 - 2023 糖尿病性腎症を抑制する新規治療ワクチンの薬効とメカニズムの解明

2019 - 2022 Regulation of chemokine signaling by post-translational modification of beta-arrestin and relationship with atherosclerosis

2018 - 2022 Investigation of vaccines using glycolipid antigens for anti-aging

2018 - 2022 Basic research for a new concurrent treatment against lifestyle diseases and Alzehimer disease.

2018 - 2021 Development of a therapeutic vaccine targeting IL17A for treatment of spondyloarthritis.

2018 - 2021 Lysosome-related molecule myoferlin on macrophages in adipose inflammation associated with obesity

2018 - 2021 Development of novel immunotherapy for chronic inflammatory diseases

2018 - 2020 Impact of bisect glycosylation

2016 - 2019 Vaccine development for renin angiotensin system

2016 - 2018 Development of vaccine therapy for pulmonary arterial hypertension

2015 - 2018 The prophylactic effect of IL-17A DNA vaccine on arthritis

2015 - 2018 Functional analysis of macrophage CYLD in age-related atherogenesis

2015 - 2018 Translational research of therapeutic vaccine to improve the quality of anti-hypertensive therapy

2015 - 2017 Development of novel immunotherapy for chronic inflammation by MDSC

2014 - 2017 Functional screening for novel molecules related to endothelial dysfunction in the ubiquitin system and the potential of their clinical application.

2014 - 2017 Angiotensin II Modulates Hypertrophic Differentiation and Apoptosis of Chondrocytes: Relationship of hypertension to Osteoarthrosis

2013 - 2016 The development of hypertension vaccine toward clinical application.

2014 - 2015 Evaluation of hypertension vaccine using pig model

2013 - 2015 DNA vaccine for diabetes and dyslipidemia

2012 - 2015 Analysis for novel function of alpha-synuclein in the endothelium and its clinical significance

2010 - 2014 Analysis of novel molecule in aging and metabolism toward translational research

2011 - 2013 Role of RAS in bone remodeling and protective effect of ARB on bone density

2011 - 2012 Development of DNA vaccine for Angiotensin II

2009 - 2012 Analysis of regulatory molecule on vascular aging

2007 - 2008 Novel therapeutic conceot of dementia through vascular axis

2006 - 2007 Novel Regeneration System based on Fat Producing Adipokine

2004 - 2005 心筋特異的誘導型過剰発現マウスの作成によるRaclの心肥大および心不全への関与

2001 - 2001 増殖因子による血管新生療法の制御因子としてのホスファターゼの機能解析

Show all

Papers (286)：

Hirotaka Fukami, Jun Morinaga, Hironori Nakagami, Hiroki Hayashi, Yusuke Okadome, Eiji Matsunaga, Tsuyoshi Kadomatsu, Haruki Horiguchi, Michio Sato, Taichi Sugizaki, et al. Efficacy and safety in mice of repeated, lifelong administration of an ANGPTL3 vaccine. npj Vaccines. 2023. 8. 1
Hiroki Hayashi, Jiao Sun, Yuka Yanagida, Takako Otera, Jiayu A. Tai, Tomoyuki Nishikawa, Kunihiko Yamashita, Naoki Sakaguchi, Shota Yoshida, Satoshi Baba, et al. Intradermal administration of DNA vaccine targeting Omicron SARS-CoV-2 via pyro-drive jet injector provides the prolonged neutralizing antibody production via germinal center reaction. Scientific Reports. 2023. 13. 1
Munehisa Shimamura, Chin yang Chang, Hiroki Hayashi, Satoshi Baba, Shota Yoshida, Hironori Nakagami. Impact of insufficient recovery of cerebral blood flow due to partial reperfusion on the pathophysiology of ischemic stroke in mice. Neuroscience Letters. 2023. 810. 137370-137370
Munehisa Shimamura, Hiroki Hayashi, Nan Ju, Shota Yoshida, Satoshi Baba, Tsutomu Sasaki, Hideki Mochizuki, Ryuichi Morishita, Hironori Nakagami. R-spondin 3/LGR4 (Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 4) Axis Is a Novel Inflammatory and Neurite Outgrowth Signaling System in the Ischemic Brain in Mice. Stroke. 2023. 54. 6. 1606-1615
Yukari Maeda, Masaya Koshizaka, Mayumi Shoji, Hiyori Kaneko, Hisaya Kato, Yoshiro Maezawa, Junji Kawashima, Kayo Yoshinaga, Mai Ishikawa, Akiko Sekiguchi, et al. Renal dysfunction, malignant neoplasms, atherosclerotic cardiovascular diseases, and sarcopenia as key outcomes observed in a three-year follow-up study using the Werner Syndrome Registry. Aging. 2023. 15. 9. 3273-3294

ｍore...

MISC (345)：

中神啓徳, 森下竜一. Development of vaccine for SARS-CoV-2. 月刊老年内科. 2021. 3. 1
中神啓徳, 森下竜一. Development of DNA vaccine for SARS-CoV-2. 循環器内科. 2021. 89. 2
玉木竜二, 農見俊明, 坂口誠, 佐藤尭彰, 天満昭子, 井上誠一, 中神啓徳, 貞光九月. Peptide Binding Prediction and Visualization of Predicted Residue Pairs Using BERT Based on a Large Scale Protein Database. 人工知能学会全国大会(Web). 2021. 35th
中神啓徳, 森下竜一. COVID-19と老年医学 7.COVID-19のワクチン療法. Geriatric Medicine. 2021. 59. 5
中神啓徳. 新規治療としてのワクチン開発. 日本高血圧学会臨床高血圧フォーラムプログラム・抄録集(CD-ROM). 2021. 9th

ｍore...

Patents (7)：

ｍore...

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page