Rchr
J-GLOBAL ID:201801018536156180   Update date: Aug. 27, 2020

Hayano Motoshi

早野 元詞 | Hayano Motoshi
Affiliation and department:
Job title: 特任講師
Homepage URL  (1): https://lab.ophthal.med.keio.ac.jp/program/hayano-team
Research field  (1): Molecular biology
Research keywords  (5): sarcopenia ,  neurodegenerative disease ,  Ophthalmology ,  epigenome ,  aging
Research theme for competitive and other funds  (5):
  • 2019 - 2021 Aging speed regulated by epigenetic memory induced during environmental stress
  • 2019 - 2021 Regulation of aging by epigenetic memory in satellite stem cell
  • 2017 - 2019 A molecular mechanism of aging through epigenome and muscle regeneration
  • 2013 - 2014 複製プログラムにおける新規細胞内機能制御機構の解析
  • 2008 - 2009 Cdc7とClaspin/Mrc1による複製フォーク形成及び安定維持機構解析
Papers (12):
  • Mio Yamane, Shinri Sato, Eisuke Shimizu, Shinsuke Shibata, Motoshi Hayano, Tomonori Yaguchi, Hajime Kamijuku, Mamoru Ogawa, Takanori Suzuki, Shin Mukai, et al. Senescence-associated secretory phenotype promotes chronic ocular graft-vs-host disease in mice and humans. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020
  • Motoshi Hayano. Erosion of the Epigenetic Landscape and Loss of Cellular Identity as a Cause of Aging in Mammals. bioRxiv. 2019
  • Motoshi Hayano. DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging. bioRxiv. 2019
  • Matsumoto, S, Kanoh, Y, Shimmoto, M, Hayano, M, Ueda, K, Fukatsu, R, Kakusho, N, Masai, H. Checkpoint-independent Regulation of Origin Firing by Mrc1 through Interaction with Hsk1 kinase. Mol. Cell. Biol. 2018. 39. 4
  • Seiji Matsumoto, Yutaka Kanoh, Michie Shimmoto, Motoshi Hayano, Kyosuke Ueda, Rino Fukatsu, Naoko Kakusho, Hisao Masai. Checkpoint-Independent Regulation of Origin Firing by Mrc1 through Interaction with Hsk1 Kinase. Molecular and cellular biology. 2017. 37. 7
more...
MISC (15):
  • 早野 元詞. 月刊「細胞」Topics from special edition【クロマチンによる外的環境記憶と老化速度制御機構】. 細胞. 2020. 52. 6. 329-332
  • 早野 元詞. 未来の骨格筋治療の可能性に迫る DNA損傷依存的エピゲノム変化による老化誘導と身体機能低下の分子機構. 体力科学. 2020. 69. 1. 20-20
  • 早野 元詞. サルコペニアと骨格筋の基礎研究 DNA損傷によるエピゲノム自己同一性破綻と老化誘導. 日本関節病学会誌. 2019. 38. 3. 228-228
  • 坪田 一男, 近藤 眞一郎, 早野 元詞, 小橋 英長, 堅田 侑作, 栗原 俊英, 明田 直彦, 羽藤 晋. 【医療×新ビジネス】《どこまで進む!?新技術の医療導入》 大学発ベンチャーの挑戦 CSV経営により社会の応援を得られるベンチャーをめざす. Modern Physician. 2019. 39. 7. 659-662
  • 早野 元詞. 個体老化の分子メカニズムの解明を目指して〜細胞老化、加齢性疾患との関りの解析〜 老化を誘導するDNA損傷によるエピゲノム自己同一性破綻. 日本抗加齢医学会総会プログラム・抄録集. 2019. 19回. 115-115
more...
Education (3):
  • 2007 - 2010 The University of Tokyo Medical genome, Ph.D
  • 2005 - 2007 The University of Tokyo Medical genome, Master degree
  • 2001 - 2005 Kumamoto University Division of biology, Bachelor
Work history (4):
  • 2017/05 - 現在 Keio University School of Medicine Research lecturer
  • 2017/07 - 2018/03 Harvard Medical School Dept. of Genetics Visiting Research Fellow
  • 2013/04 - 2017/06 Harvard Medical School Dept. of Genetics Research Fellow
  • 2011/04 - 2013/03 Tokyo Metropolitan Institute of Medical Science Genome Dynamics post-doctoral fellow
Awards (2):
  • 2014/05 - Human Frontier Science Program Long-Term Fellowships (LTF)
  • 2014/04 - Japan Society for the Promotion of Science Overseas Research Fellow
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