Kasahara Takaoki

カサハラタカオキ | Kasahara Takaoki

Affiliation and department：
Job title： Research Fellow

Research field (3)： Animals: biochemistry, physiology, behavioral science , Psychiatry , Genomics

Research theme for competitive and other funds (15)：

2020 - 2023 蛍光を発しないGFPホモログ(色素タンパク質)を利用した神経科学研究ツールの開発
2017 - 2022 Role of paraventricular thalamic nucleus in bipolar disorder
2016 - 2021 統計学的遺伝環境相互作用解析を用いた気分障害の新規治療・診断法の開発、および気分障害リスク遺伝子の生物学的意義の評価および治療薬シーズの開発
2016 - 2019 Molecular mechanisms underlying control of melatonin physiology
2015 - 2016 マウス偽常染色体領域の塩基配列決定

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Papers (39)：

Takumi Nakamura, Toru Yoshihara, Chiharu Tanegashima, Mitsutaka Kadota, Yuki Kobayashi, Kurara Honda, Mizuho Ishiwata, Junko Ueda, Tomonori Hara, Moe Nakanishi, et al. Transcriptomic dysregulation and autistic-like behaviors in Kmt2c haploinsufficient mice rescued by an LSD1 inhibitor. Molecular psychiatry. 2024
Hirona Yamamoto, Hyeon-Cheol Lee-Okada, Masashi Ikeda, Takumi Nakamura, Takeo Saito, Atsushi Takata, Takehiko Yokomizo, Nakao Iwata, Tadafumi Kato, Takaoki Kasahara. GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice. Molecular psychiatry. 2023
Takaoki Kasahara, Kazuyuki Mekada, Kuniya Abe, Alan Ashworth, Tadafumi Kato. Complete sequencing of the mouse pseudoautosomal region, the most rapidly evolving ‘chromosome’. bioRxiv. 2022
Youhei Obata, Mie Kubota-Sakashita, Takaoki Kasahara, Masafumi Mizuno, Takahiro Nemoto, Tadafumi Kato. Phenethylamine is a substrate of monoamine oxidase B in the paraventricular thalamic nucleus. Scientific reports. 2022. 12. 1. 17-17
Hiroko Sugawara, Miki Bundo, Takaoki Kasahara, Yutaka Nakachi, Junko Ueda, Mie Kubota-Sakashita, Kazuya Iwamoto, Tadafumi Kato. Cell-type-specific DNA methylation analysis of the frontal cortices of mutant Polg1 transgenic mice with neuronal accumulation of deleted mitochondrial DNA. Molecular brain. 2022. 15. 1. 9-9

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MISC (49)：

From genome to ion : toward biological understandings of bipolar disorder. 2019. 51. 14. 710-713
Kasahara Takaoki. Deleteriousness of rare variants in patients with bipolar disorder assessed by biochemical analysis, computer prediction, etc. Japanese Journal of Biological Psychiatry. 2019. 30. 1. 3-9
Tadafumi Kato, Takaoki Kasahara. Response to 'POLG1 mutations in bipolar disorders'. PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2017. 71. 8. 569-U86
笠原和起. フグは食いたし命は惜しし. 脳科学豆知識(日本脳科学関連学会連合webサイト). 2017
Yuki Kageyama, Takaoki Kasahara, Yasuhiko Deguchi, Munehide Tani, Kenji Kuroda, Kotaro Hattori, Sumiko Yoshida, Koki Inoue, Tadafumi Kato. A Clinical Pilot Study of Plasma Mitochondrial DNA as a Biomarker for Bipolar Disorder. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2016. 19. 71-71

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Education (3)：

1998 - 2001 The University of Tokyo Graduate School of Science Department of Biophysics and Biochemistry
1996 - 1998 The University of Tokyo Graduate School of Arts and Sciences
1992 - 1996 The University of Tokyo College of Arts and Sciences Department of Basic Science

Professional career (1)：

Work history (9)：

2022/10 - 現在 Carl von Ossietzky University Oldenburg Institute of Biology and Environmental Sciences, School of Mathematics and Science Research Fellow
2021/04 - 2022/09 RIKEN Center for Brain Science Neurodegenerative Disorders Collaboration Laboratory Senior Scientist
2020/04 - 2022/09 理化学研究所脳神経科学研究センター上級研究員
2020/04 - 2021/03 理化学研究所脳神経科学研究センター精神疾患動態研究チーム研究員
2018 - 2020/04 理化学研究所脳神経科学研究センター精神疾患動態研究チーム副チームリーダー

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Committee career (1)：

Awards (3)：

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