Research keywords (3)：
protein crystal
, Synchrotron radiation
, X-ray crystallography
Research theme for competitive and other funds (5)：
2024 - 2027 High-Temperature X-ray Crystallography on the Proteins from Thermophiles, Opening the Way to Protein Science in Extreme Environments
2023 - 2027 Real-time structural dynamics analysis in protein crystal under controlled environmental conditions (temperature and pH).
2023 - 2026 速度論および熱力学的手法を用いた"in crystallo" 酵素反応解析
2020 - 2023 非凍結結晶を用いた“in crystallo”酵素反応解析
2017 - 2021 In crystallo thermodynamic analysis of the cofactor conformational change of copper amine oxidase
Papers (88)：
Kenji Fukui, Naoyuki Kondo, Takeshi Murakawa, Seiki Baba, Takashi Kumasaka, Takato Yano. dUTP pyrophosphatases from hyperthermophilic eubacterium and archaeon: Structural and functional examinations on the suitability for PCR application. Protein science : a publication of the Protein Society. 2024. 33. 11. e5185
Naoki Nemoto, Seiki Baba, Gota Kawai, Gen Ichi Sampei. Crystal structure of guanosine 5'-monophosphate synthetase from the thermophilic bacterium Thermus thermophilus HB8. Acta crystallographica. Section F, Structural biology communications. 2024
Gota Kawai, Kiyoshi Okada, Seiki Baba, Asako Sato, Taiichi Sakamoto, Akio Kanai. Homo-trimeric structure of the ribonuclease for rRNA processing, FAU-1, from Pyrococcus furiosus. The Journal of Biochemistry. 2024
Kenji Fukui, Tatsuya Yamamoto, Takeshi Murakawa, Seiki Baba, Takashi Kumasaka, Takato Yano. Catalytic mechanism of the zinc-dependent MutL endonuclease reaction. Life Science Alliance. 2023. 6. 10. e202302001-e202302001
Seiki BABA, Takeshi MURAKAWA. X-ray Crystallographic Analysis of Copper Amine Oxidase in Physiological Environments using Humid Air and Glue-coating(HAG)Method. Nihon Kessho Gakkaishi. 2022. 64. 4. 285-289
出原 啓介, 福井 健二, 村川 武志, 馬場 清喜, 熊坂 崇, 内山 和久, 矢野 貴人. DNAミスマッチ修復系エンドヌクレアーゼであるMutLのATP結合部位におけるリンチ症候群関連の変異はMutLの構造を不安定化させる-A Lynch syndrome-associated mutation at a Bergerat ATP-binding fold destabilizes the structure of the DNA mismatch repair endonuclease MutL. 大阪医科薬科大学医学会雑誌 = Journal of the Medical Association of Osaka Medical and Pharmaceutical University. 2021. 80. 1・2. 85-91
