Research keywords (3)：
protein crystal
, Synchrotron radiation
, X-ray crystallography
Research theme for competitive and other funds (4)：
2023 - 2027 Real-time structural dynamics analysis in protein crystal under controlled environmental conditions (temperature and pH).
2023 - 2026 速度論および熱力学的手法を用いた"in crystallo" 酵素反応解析
2020 - 2023 非凍結結晶を用いた“in crystallo”酵素反応解析
2017 - 2021 In crystallo thermodynamic analysis of the cofactor conformational change of copper amine oxidase
Papers (86)：
Gota Kawai, Kiyoshi Okada, Seiki Baba, Asako Sato, Taiichi Sakamoto, Akio Kanai. Homo-trimeric structure of the ribonuclease for rRNA processing, FAU-1, from Pyrococcus furiosus. The Journal of Biochemistry. 2024
Kenji Fukui, Tatsuya Yamamoto, Takeshi Murakawa, Seiki Baba, Takashi Kumasaka, Takato Yano. Catalytic mechanism of the zinc-dependent MutL endonuclease reaction. Life Science Alliance. 2023. 6. 10. e202302001-e202302001
Seiki BABA, Takeshi MURAKAWA. X-ray Crystallographic Analysis of Copper Amine Oxidase in Physiological Environments using Humid Air and Glue-coating(HAG)Method. Nihon Kessho Gakkaishi. 2022. 64. 4. 285-289
Maya Nakatani, Shun-ya Nakahara, Kenji Fukui, Momoka Urano, Yuki Fujii, Takeshi Murakawa, Seiki Baba, Takashi Kumasaka, Hiroki Okanishi, Yoshikatsu Kanai, et al. Crystal structure of a nucleotide-binding domain of fatty acid kinase FakA from Thermus thermophilus HB8. Journal of Structural Biology. 2022. 214. 4. 107904-107904
Tetsuya Masuda, Kyohei Okubo, Seiki Baba, Mamoru Suzuki, Fumito Tani, Masayuki Yamasaki, Bunzo Mikami. Structure of thaumatin under acidic conditions: Structural insight into the conformations in lysine residues responsible for maintaining the sweetness after heat-treatment. Food chemistry. 2022. 389. 132996-132996
出原 啓介, 福井 健二, 村川 武志, 馬場 清喜, 熊坂 崇, 内山 和久, 矢野 貴人. DNAミスマッチ修復系エンドヌクレアーゼであるMutLのATP結合部位におけるリンチ症候群関連の変異はMutLの構造を不安定化させる-A Lynch syndrome-associated mutation at a Bergerat ATP-binding fold destabilizes the structure of the DNA mismatch repair endonuclease MutL. 大阪医科薬科大学医学会雑誌 = Journal of the Medical Association of Osaka Medical and Pharmaceutical University. 2021. 80. 1・2. 85-91
