Yoshihiro Tsuchiya

Affiliation and department：

Research field (2)： Medical biochemistry , Tumor biology

Research keywords (8)： IKK , TNFα , UV , NF-κB , 肝線維化 , 肝硬変 , 肝炎 , 肝臓

Research theme for competitive and other funds (3)：

2016 - 2018 核内IKKβを介した肝線維化と肝がん発症の制御機構
2013 - 2015 細胞内局在特異的なIKKβを介したネクローシスの制御と炎症と発がんの連関
2011 - 2012 新規経路を介した持続的NF-κB活性化と炎症と発癌との連関

Papers (18)：

Kanamoto M, Tsuchiya Y, Nakao Y, Suzuki T, Motohashi H, Yamamoto M, Kamata H. Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding. PLoS ONE. 2018. 13(11). e0203978
Yoshihiro Tsuchiya, Keiko Osaki, Mayu Kanamoto, Yuki Nakao, Ena Takahashi, Toru Higuchi, Hideaki Kamata. Distinct B subunits of PP2A regulate the NF-kappa B signalling pathway through dephosphorylation of IKK beta, I kappa B alpha and ReIA. FEBS LETTERS. 2017. 591. 24. 4083-4094
松永泰花, 中津祐介, 福嶋俊明, 大久保博史, 岩下未咲, 迫田秀之, 藤城緑, 山本屋武, 櫛山暁史, 高橋伸一郎, et al. 非アルコール性脂肪性肝炎におけるLUBAC形成障害の解析. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [4T特-04(3P1180)]
Takanori Shinjo, Yusuke Nakatsu, Misaki Iwashita, Tomomi Sano, Hideyuki Sakoda, Hisamitsu Ishihara, Akifumi Kushiyama, Midori Fujishiro, Toshiaki Fukushima, Yoshihiro Tsuchiya, et al. DPP-IV inhibitor anagliptin exerts anti-inflammatory effects on macrophages, adipocytes, and mouse livers by suppressing NF-kappa B activation. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2015. 309. 3. E214-E223
Ryuhei Kanaoka, Akifumi Kushiyama, Yasuyuki Seno, Yusuke Nakatsu, Yasuka Matsunaga, Toshiaki Fukushima, Yoshihiro Tsuchiya, Hideyuki Sakoda, Midori Fujishiro, Takeshi Yamamotoya, et al. Pin1 Inhibitor Juglone Exerts Anti-Oncogenic Effects on LNCaP and DU145 Cells despite the Patterns of Gene Regulation by Pin1 Differing between These Cell Lines. PLOS ONE. 2015. 10. 6. e0127467

ｍore...

MISC (1)：

Misaki Iwashita, Sonoko Kumamoto, Akifumi Kushiyama, Yusuke Nakatsu, Yoshihiro Tsuchiya, Hideyuki Sakoda, Midori Fujishiro, Yuichiro Otani, Takako Kikuchi, Fusanori Nishimura, et al. Valsartan Suppresses Inflammatory Response of LPS-Induced Activated Macrophages and Thereby Improves Adipose Insulin Resistance. DIABETES. 2010. 59. A118-A118

Books (1)：

TNFα によるリン酸化シグナルと酸化ストレスのクロストークと細胞死
活性酸素, 医学のあゆみ 2013

Lectures and oral presentations (1)：

Transactivation domain (TAD) of regulates IκB kinase β (IKKβ) activity
(2023)

Professional career (1)：

医学(博士)

Work history (2)：

2013/04 - 2017/03 Hiroshima University Graduate School of Biomedical Sciences
2011/04 - 2013/03 Hiroshima University

Awards (3)：

2014 - 第87回日本生化学会大会若手優秀発表賞
2012 - 第85回日本生化学会大会鈴木紘一メモリアル賞
2011/03 - 広島大学学生表彰学術研究部門最優秀賞

Association Membership(s) (2)：

THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY

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