Yoko Sakai

サカイヨウコ | Yoko Sakai

Affiliation and department：

Research field (1)： Clinical pharmacy

Research theme for competitive and other funds (5)：

2022 - 2025 灌流型小腸-肝臓2臓器連結デバイスを用いた胆汁鬱滞肝毒性評価系の展開
2020 - 2022 NTCP,BSEP強制発現HepG2細胞を用いた薬剤性胆汁鬱滞型肝障害評価
2019 - 2020 NTCP強制発現HepG2細胞によるin vitro薬剤性胆汁鬱滞型肝障害評価法
2019 - Development of in vitro cholestatic drug-induced liver injury evaluation system using HepG2-hNTCP-C4 cells with sandwich culture
2017 - 2019 ヒトiPS細胞由来肝細胞を用いたin vitro胆汁うっ滞型肝障害試験法の構築

Papers (9)：

Yoko Sakai, Masanari Matsumura, Hideki Yamada, Atsushi Doi, Isao Saito, Takahiro Iwao, Tamihide Matsunaga. Development of a Perfusing Small Intestine-Liver Microphysiological System Device. Applied Sciences. 2023. 13. 18. 10510-10510
Yoko Sakai, Masanari Matsumura, Takahiro Iwao, Tamihide Matsunaga. Culture methods focusing on bile canalicular formation using primary human hepatocytes in a short time. In Vitro Cellular & Developmental Biology - Animal. 2023. 59. 8. 606-614
Mostafa Ahmed*, Yoko Sakai*, Makoto Fukudome, De-Qi Yuan (*筆頭著者). Cucurbit[7]uril: Synthesis and quenching the quorum sensing in bacteria. Journal of Molecular Structure. 2022. 1248. 131505-131505
Chika Yamamoto, Akinori Takemura, Sanae Ishii, Atsushi Doi, Isao Saito, Hideki Yamada, Yoko Sakai, Tamihide Matsunaga, Kousei Ito. A novel perfusion culture system for screening mitochondrial toxicity in primary mouse hepatocytes. The Journal of Toxicological Sciences. 2022. 47. 1. 13-18
Akiko KOEDA, Takahiro IWAO, Anna NAKANISHI, Shota MIZUNO, Misaki YAMASHITA, Yoko SAKAI, Katsunori NAKAMURA, Tamihide MATSUNAGA. Comparison of the Inducibility of CYP mRNA Exposed to Typical Inducers in Fresh and Cryopreserved Cynomolgus Monkey Hepatocytes. Drug Metab. Pharmacokinet. 2020. 35. 3. 304-312

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MISC (27)：

Kotaro Shirai, Masami Fukaya, Yoko Sakai, Takahiro Iwao, Tamihide Matsunaga. Characterization of new human induced pluripotent stem cell-derived intestinal epithelial cells and their application to an integrated small intestine liver device. 2023
Yoko Sakai, Masanari Matsumura, Takahiro Iwao, Shigehiro Osada, Tamihide Matsunaga. Culture method of human primary hepatocytes forming bile canaliculus in short time 著者名. 2022
Long-term culture of human hepatocytes in a perfusing small intestine-liver connected device. 2022
堺陽子. In vitro 胆汁うっ滞肝毒性評価系の確立. DMPK_News Letter(NL)「若手が取り組む動態研究」. 2022. 37. 2
深谷壮弥, 堺陽子, 岩尾岳洋, 松永民秀. 小腸-肝臓2臓器連結デバイスでのヒト凍結肝細胞長期培養. 日本薬物動態学会年会講演要旨集第36年会. 2021

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Lectures and oral presentations (10)：

ヒト凍結肝細胞を用いた短期間で毛細胆管を形成する培養法の確立
(第73回日本薬学会関西支部総会・大会 2023)
Culture method of human primary hepatocytes forming bile canaliculus in short time
(2022)
Long-term culture of human hepatocytes in a perfusing small intestine-liver connected device
(2022)
ヒトiPS細胞由来肝細胞のNTCPに対する因子X添加の影響
(細胞アッセイ研究会シンポジウム2022 2022)
初回通過効果の評価を行うための小腸-肝臓2臓器連結デバイスの有用性
(細胞アッセイ研究会シンポジウム2021 2021)

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Professional career (1)：

Work history (3)：

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