Research field (2)：
Pharmaceuticals - analytical and physicochemistry
, Pharmaceuticals - health and biochemistry
Research keywords (5)：
Relationship between structures and activities
, Gas sensors
, Intermolecular interactions
, Cytochrome P450s
, Heme proteins
Research theme for competitive and other funds (10)：
2021 - 2024 新規抗結核薬の創薬ターゲットの機能解明および検出キット作製への応用
2018 - 2022 Interpretability of Machine Learning-Assisted Control Methods through Stochastic Controllability Analysis
2014 - 2018 Control systems that utilize interaction with environmental fluctuation
2011 - 2014 Chain Reaction of Drug Metabolism -A Comprehensive Study on the Cooperative and Competitive Drug Metabolism by CYP Isoforms
2011 - 2013 The Elucidation on mechanism of drug metabolism by a statistic and dynamics approaches.
2005 - 2006 ガスセンサータンパク質におけるガス分子認識および機能発現機構解明
1999 - 2004 タンパク質:変異による機能改変及び構造解析
1999 - 2004 Protein : Alteration of function and Structural analysis in mutation
2004 - Protein: Crystal structural analysis
2004 - タンパク質:結晶構造解析
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Papers (35)：
Jun Haginaka, Taku Yamashita, Hirofumi Tsujino, Mitsuhiro Arisawa. Revisiting chiral recognition mechanism on chicken alpha 1-acid glycoprotein: Location of chiral binding sites and insight into chiral binding mechanism. Separations. 2021. 8. 6
Honami Kojima, Toshio Kurihara, Miyako Yoshida, Tamami Haraguchi, Haruka Nishikawa, Saeri Ikegami, Takayoshi Okuno, Taku Yamashita, Junichi Nishikawa, Hirofumi Tsujino, et al. A New Bitterness Evaluation Index Obtained Using the Taste Sensor for 48 Active Pharmaceutical Ingredients of Pediatric Medicines. Chemical & pharmaceutical bulletin. 2021. 69. 6. 537-547
Sayed M. Derayea, Hirofumi Tsujino, Yukiko Oyama, Yoshinobu Ishikawa, Taku Yamashita, Tadayuki Uno. Impact of single nucleotide polymorphisms (R132Q and W120R) on the binding affinity and metabolic activity of CYP2C19 toward some therapeutically important substrates. Xenobiotica. 2020. 50. 12. 1510-1519
T Yamashita, T Uno, Y Ishikawa. Stabilization of guanine quadruplex DNA by the binding of porphyrins with cationic side arms. BIOORGANIC & MEDICINAL CHEMISTRY. 2005. 13. 7. 2423-2430
K ABE, K AMAKO, Y ARAI, Y ASANO, M CHIBA, Y CHIBA, M DAIGO, T EMURA, ENDO, I, M FUKAWA, et al. SEARCH FOR A 4TH-GENERATION QUARK WITH ABSOLUTE-VALUE OF Q = E/3 IN E+E- COLLISIONS AT SQUARE-ROOT S = 56-57 GEV. PHYSICAL REVIEW D. 1989. 39. 11. 3524-3527
Education (3)：
2001 - 2004 Kumamoto University
1999 - 2001 Kumamoto University
1995 - 1999 Kumamoto University
Work history (6)：
2014/04 - 現在 Mukogawa Women's University School of Pharmacy and Pharmaceutical Sciences Associate Professor
2013/04 - 2014/03 Osaka University Institute for Academic Initiatives Specially Appointed Associate Professor
2008/07 - 2013/03 Osaka University Graduate School of Pharmaceutical Sciences Assistant Professor
