Hiroshi Abe

アベヒロシ | Hiroshi Abe

Affiliation and department：
Job title：教授

Research field (1)： Bioorganic chemistry

Research theme for competitive and other funds (22)：

2021 - 2025 Development and therapeutic application of short mRNA therapeutics based on mRNA engineering
2021 - 2024 修飾塩基を持つRNAの情報解析基盤技術の開発
2018 - 2023 化学を基盤とするゲノムスケールDNA合成技術の開発
2018 - 2020 Medium molecularization strategy of high molecular weight RNA medicine
2016 - 2019 Improvement of catalytic turnover based on transition state control of oligonucleotide template chemical reaction

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Papers (176)：

Sana Ohashi, Mayu Nakamura, Susit Acharyya, Masahito Inagaki, Naoko Abe, Yasuaki Kimura, Fumitaka Hashiya, Hiroshi Abe. Development and Comparison of 4-Thiouridine to Cytidine Base Conversion Reaction. ACS Omegam. 2024. 9. 8. 9300-9308
Kohei Nomura, Kaoru Onda, Hirotaka Murase, Fumitaka Hashiya, Yukiteru Ono, Goro Terai, Natsuhisa Oka, Kiyoshi Asai, Daisuke Suzuki, Naho Takahashi, et al. Development of PCR Primer Enabling the Design of Flexible Sticky Ends for Efficient Concatenation of Long DNA Fragments. RSC Chemical Biology. 2024
Fangjie Lyu, Takashi Tomita, Naoko Abe, Haruka Hiraoka, Fumitaka Hashiya, Yuko Nakashima, Shiryu Kajihara, Fumiaki Tomoike, Zhaoma Shu, Kazumitsu Onizuka, et al. Topological capture of mRNA for silencing gene expression. Chemical communications (Cambridge, England). 2023. 59. 77. 11564-11567
Fumitaka Hashiya, Hirotaka Murase, Akash Chandela, Haruka Hiraoka, Masahito Inagaki, Yuko Nakashima, Naoko Abe, Mayu Nakamura, Goro Terai, Yasuaki Kimura, et al. The effect of γ phosphate modified deoxynucleotide substrates on PCR activity and fidelity. Chembiochem : a European journal of chemical biology. 2023. 24. 14. e202200572
Shogo Hasegawa, Masahito Inagaki, Shunichi Kato, Zhenmin Li, Yasuaki Kimura, Hiroshi Abe. Synthesis of nucleoside oligophosphates by electrophilic activation of phosphorothioate. Organic & biomolecular chemistry. 2023. 21. 19. 3997-4001

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MISC (37)：

馬場麟太郎, 野村浩平, 阿部奈保子, 安成鎮, 小林芳明, 程久美子, 橋谷文貴, 木村康明, 阿部洋. 新規2′修飾核酸によるsiRNAの標的特異性の向上. 中部化学関係学協会支部連合秋季大会講演予稿集. 2021. 52nd (CD-ROM)
野村浩平, 村瀬裕貴, 中本航介, 木村康明, 阿部奈保子, AN Seongjin, 小林芳明, 程久美子, 程久美子, 阿部洋, et al. Synthesis of chemically modified nucleic acids and their application to nucleic acid drugs. 日本薬学会年会要旨集(Web). 2021. 141st
Daichi Fushihara, Hayato Fukuda, Hiroshi Abe, Satoshi Shuto. Synthesis of 1,1,2-Trisubstituted Cyclopropane Nucleosides in Enantiomerically Pure Forms (vol 38, pg 921, 2019). NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS. 2020. 39. 1-3. 471-471
Nakamoto Kosuke, Shu Zhaoma, Abe Hiroshi. Disulfide-unit Conjugation Enables Ultrafast Cytosolic Internalization of Antisense DNA and siRNA. Journal of Synthetic Organic Chemistry, Japan. 2020. 78. 5. 456-464
福井竜介, 新美結士, 片倉秀雄, 鈴木哲郎, 村上努, 児玉栄一, 木村康明, 阿部洋. ウイルスタンパク質の活性をトリガーとした新規不可逆阻害剤の開発. 日本薬学会年会要旨集(CD-ROM). 2019. 139th. 2. ROMBUNNO.23K-pm11-103

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Patents (16)：

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Books (18)：

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Lectures and oral presentations (93)：

evelopment of mRNA medicine based on chemistry.
(第40回日本DDS学会大会 2024)
分子創製に基づくRNA研究の展開
(第124回有機合成シンポジウム 2024)
mRNA医薬の開発: 課題認識から創薬研究展開、そしてスタートアップ創業への道
(大学院講義ならびにアントレプレナーシップ教育セミナー 2024)
Chemistry-based mRNA design for the efficient translation
(IRTG meeting 2024)
Chemistry-based mRNA design for the efficient translation
(ISBC2024 Nagoya 2024)

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Education (4)：

Work history (10)：

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Awards (7)：

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