Ohno Mizuki

• 2024 - 2029 卵子が持つ精子DNA損傷を修復する能力の分子機構解明と次世代ゲノム影響の解析
• 2022 - 2026 心臓アンチエイジング薬の開発を目指したヒトiPS細胞由来老化心筋モデルの構築
• 2022 - 2025 初等教育における遺伝リテラシー向上のためのSTEAM教育プログラム開発の検討
• 2020 - 2024 卵子が持つ精子DNA損傷を修復する能力の分子機構の解明
• 2019 - 2020 動物実験を用いた慢性的低線量内部被ばくによる突然変異と発がんの非相関性のメカニズム解明
2017 - 2019 An attempt to quantify and evaluate the effect of in vitro fertilization on the genomic information of offspring
2016 - 2019 Characterization of mutation as a marker for carcinogenesis induced by oxidative stress: identification of mutation hotspot
2015 - 2019 Analysis of genome maintenance mechanism in pluripotent stem cells: toward highly sensitive mutation detection methods
2017 - 2018 体外受精が子孫のゲノム情報に与える影響を定量・評価する試み
2014 - 2017 Analysis of de novo germline mutations by using environmental genome stress-sensitive mice
2013 - 2017 Oxidative stress-induced mutagenesis and carcinogenesis in DNA repair-deficient mice
2013 - 2017 Detection of mouse germline mutations by ultra-throughput genomic analyses and development of the risk assessment system for low-dose mutagens
2013 - 2015 The role of non-S DNA synthesis on the local mutation rate
2010 - 2012 Study of molecular mechanisms of germline mutation by using DNA repair deficient mice
2009 - 2010 DNA修復欠損マウスを用いたエピミューテーションの解析
2008 - 2009 Oxidative stress-induced tumorigenesis in the small intestines of various types of DNA repair-deficient mice

• Hiroo Nakajima, Mizuki Ohno, Kazuko Uno, Satoru Endo, Masatoshi Suzuki, Hiroshi Toki, Tadashi Saito. Effects of generational low dose-rate 137Cs internal exposure in descendant mice. International journal of radiation biology. 2024. 1-19
• Mizuki Ohno, Noriko Takano, Kyoko Hidaka, Fumiko Sasaki, Kazumi Yamauchi, Yasunobu Aoki, Takehiko Nohmi, Yusaku Nakabeppu, Yoshimichi Nakastu, Teruhisa Tsuzuki. Oxidative stress accelerates intestinal tumorigenesis by enhancing 8-oxoguanine-mediated mutagenesis in MUTYH-deficient mice. Genome research. 2024
• Sugako Oka, Teruhisa Tsuzuki, Masumi Hidaka, Mizuki Ohno, Yoshimichi Nakatsu, Mutsuo Sekiguchi. Endogenous ROS production in early differentiation state suppresses endoderm differentiation via transient FOXC1 expression. Cell death discovery. 2022. 8. 1. 150-150
• Yasunobu Aoki, Mizuki Ohno, Michiyo Matsumoto, Michi Matsumoto, Kenichi Masumura, Takehiko Nohmi, Teruhisa Tsuzuki. Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice. Genes and environment : the official journal of the Japanese Environmental Mutagen Society. 2021. 43. 1. 27-27
• Yasunobu Aoki, Yosuke Taniguchi, Michiyo Matsumoto, Michi Matsumoto, Mizuki Ohno, Kenichi Masumura, Shigeki Sasaki, Teruhisa Tsuzuki, Masayuki Yamamoto, Takehiko Nohmi. Oxidative-stress-driven mutagenesis in the small intestine of the gpt delta mouse induced by oral administration of potassium bromate. Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 2020. 850-851. 503136-503136

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• 中島 裕美子, 安富祖 仁, 佐藤 直紀, 藤淵 俊王, 野邉 由紀子, 大野 みずき, 平田 悠真, 山里 眞, 續 輝久, 玉城 史朗. 国民の放射線リテラシーの向上:医療系人材養成課程と全学教育 学内の日本人学生の放射線に対する意識の変遷と外国人の放射線業務従事者の放射線についての知識の現状. 日本放射線影響学会大会講演要旨集. 2018. 61回. 28-28
• 大野 みずき, 鷹野 典子, 中津 可道, 續 輝久. ミスマッチ修復欠損マウスにおける体細胞および生殖細胞自然突然変異の解析. 日本放射線影響学会大会講演要旨集. 2018. 61回. 83-83
• 續 輝久, 大野 みずき, 鷹野 典子, 田口 健一, 中別府 雄作, 中津 可道. 放射線発がんの分子生物学 DNA修復遺伝子欠損マウスを用いた酸化ストレス誘発発がんに関する研究. 生命科学系学会合同年次大会. 2017. 2017年度. [2AS01-4]
• 作見 邦彦, 大野 みずき, 中別府 雄作. 遺伝性疾患自然発症モデル動物としてのmutator mouse. 生命科学系学会合同年次大会. 2017. 2017年度. [2PT26-09(3P
• 大野 みずき, 鷹野 典子, 佐々木 史子, 作見 邦彦, 中別府 雄作, 中津 可道, 續 輝久. 発がんの変異シグネチャー 遺伝性大腸がんモデルマウスにおける酸化ストレス誘発発がんと体細胞突然変異の解析. 日本放射線影響学会大会講演要旨集. 2017. 60回. 69-69

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• Toward understanding de novo germline mutations in mammals
  (16th International Congress of Radiation Research(ICRR)2019 2019)
• Application of transgenic mice to analyze genotoxic effects induced by non-thermal atmospheric air plasma
  (10th Anniversary International Symposium on Advanced Plasma Science and its Applications for Nitrides and Nanomaterials/11th International Conference on Plasma-Nano Technology & Science. (ISPlasma2018 / IC-PLANTS2018) 2018)
• The impact of DNA repair status on germline mutation rate and spectra in mice
  (SMBE2018 (Society for Molecular Biology and Evolution) 2018)
• 多世代にわたり低線量137Cs 内部被曝したA / J およびB6 マウスにおける全ゲノム解析
  (日本環境変異原学会第47回大会 2018)
• Oxidative stress-induced tumorigenesis: Lesson from the experiments with DNA repair-deficient mice.
  (Beijing Symposium on “Genomic Stability and Accurate Gene Expression under Oxidative Stress” 2018)

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日本遺伝学会 ,  THE JAPANESE RADIATION RESEARCH SOCIETY ,  THE JAPANESE ENVIRONMENTAL MUTAGEN SOCIETY ,  THE MOLECULAR BIOLOGY SOCIETY OF JAPAN ,  THE JAPANESE CANCER ASSOCIATION ,  SOCIETY OF EVOLUTIONARY STUDIES, JAPAN