Rchr
J-GLOBAL ID：201901003665540361
Update date: Jan. 30, 2024
Kurahashi Toshihiro
Kurahashi Toshihiro
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Affiliation and department：
Kyoto Prefectural University of Medicine
About Kyoto Prefectural University of Medicine
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Research field (3)：
Medical biochemistry
, Biomedical engineering
, Applied molecular and cellular biology
Research theme for competitive and other funds (5)：
2020 - 2023 アスコルビン酸によるケミカルダイレクトリプログラミング促進機構の解明
2017 - 2020 Development of chemical compound-based direct reprogramming method for human retinal pigment epithelial cells
2015 - 2018 Roles of transsulfuration-mediated cysteine uptake and hydrogen sulfide in liver
2013 - 2017 Studies on the physiological role of Prx4 in oxidative protein folding
2011 - 2012 Studies of chromatin architectural protein HMGN3 in pancreaticbeta-cell
Papers (35)：
Takujiro Homma, Yuji Takeda, Tomoyuki Nakano, Shinya Akatsuka, Daisuke Kinoshita, Toshihiro Kurahashi, Shinichi Saitoh, Ken-Ichi Yamada, Satoshi Miyata, Hironobu Asao, et al. Defective biosynthesis of ascorbic acid in Sod1-deficient mice results in lethal damage to lung tissue. Free radical biology & medicine. 2021. 162. 255-265
Takujiro Homma, Toshihiro Kurahashi, Naoki Ishii, Nobuyuki Shirasawa, Junichi Fujii. Testis-specific peroxiredoxin 4 variant is not absolutely required for spermatogenesis and fertility in mice. Scientific reports. 2020. 10. 1. 17934-17934
Homma T, Kurahashi T, Lee J, Nabeshima A, Yamada S, Fujii J. Double Knockout of Peroxiredoxin 4 (Prdx4) and Superoxide Dismutase 1 (Sod1) in Mice Results in Severe Liver Failure. Oxidative medicine and cellular longevity. 2018. 2018. 2812904-2812904
Eisuke Tasaki, Shotaro Matsumoto, Hisashi Tada, Toshihiro Kurahashi, Xuhong Zhang, Junichi Fujii, Toshihiko Utsumi, Yoshihito Iuchi. Protective role of testis-specific peroxiredoxin 4 against cellular oxidative stress. JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION. 2017. 60. 3. 156-161
Takaya Shirato, Takujiro Homma, Jaeyong Lee, Toshihiro Kurahashi, Junichi Fujii. Oxidative stress caused by a SOD1 deficiency ameliorates thioacetamide-triggered cell death via CYP2E1 inhibition but stimulates liver steatosis. ARCHIVES OF TOXICOLOGY. 2017. 91. 3. 1319-1333
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MISC (12)：
Effects of Genistein on Prx4 and SOD1 Double Knockout Mouse as an in vivo Model for Exploring Oxidative and ER Stress-induced Hepatic Disorder. 2017. 19. 37. 143-146
石井直樹, 本間拓二郎, 倉橋敏裕, 浜島真司, 白澤信行, 井内良仁, 藤井順逸. 精子形成過程におけるレドックス因子ペルオキシレドキシン4の機能解析. 山形大学紀要 医学(Web). 2017. 35. 1
松本勝太郎, 多田久志, 田崎英祐, 倉橋敏裕, 張旭紅, 藤井順逸, 井内良仁. 抗酸化酵素ペルオキシレドキシン4bの機能解析. 日本分子生物学会年会プログラム・要旨集(Web). 2014. 37th
李 在勇, 倉橋 敏裕, 権 明秀, 高橋 素子, 大槻 倫之, 伊藤 純一, 松岡 悠太, 山田 健一, 宮田 哲, 佐藤 英世, et al. AKR1AならびにxCT遺伝子改変マウスを用いた低分子量レドックス分子のクロストークに関する研究. 日本生化学会大会プログラム・講演要旨集. 2013. 86回. 3P-176
権 明秀, 大槻 倫之, 金野 祐, 角田 智志, 倉橋 敏裕, 伊藤 純一, 高橋 素子, 宮田 哲, 藤井 順逸. 遺伝子改変マウスおよびマウス胎仔線維芽細胞を用いたアルデヒド還元酵素AKR1Aの機能解析. 山形医学. 2013. 31. 2. 55-55
ｍore...
Work history (4)：
2015/10 - 現在 Kyoto Prefectural University of Medicine
2010/09 - 2015/09 Yamagata University
2006/11 - 2010/08 National Institute of Health / National Cancer Institute Laboratory of Metabolism / Protein section
2006/04 - 2006/10 RIKEN
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