Art

J-GLOBAL ID：201902287518349790   Reference number：19A2049060

Double Knockout of Peroxiredoxin 4 (Prdx4) and Superoxide Dismutase 1 (Sod1) in Mice Results in Severe Liver Failure

マウスにおけるペルオキシレドキシン4(PRDX4)とスーパーオキシドジスムターゼ1(SOD1)の二重ノックアウトは重度の肝不全を生じる【JST・京大機械翻訳】

Author (6)： Homma Takujiro (Department of Biochemistry and Molecular Biology, Graduate School of Medical Sciences, Yamagata University, Yamagata, Japan) ,  Kurahashi Toshihiro (Department of Biochemistry and Molecular Biology, Graduate School of Medical Sciences, Yamagata University, Yamagata, Japan) ,  Lee Jaeyong (Department of Biochemistry and Molecular Biology, Graduate School of Medical Sciences, Yamagata University, Yamagata, Japan) ,  Nabeshima Atsunori (Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan) ,  Yamada Sohsuke (Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan) ,  Fujii Junichi (Department of Biochemistry and Molecular Biology, Graduate School of Medical Sciences, Yamagata University, Yamagata, Japan)
Material： Oxidative Medicine and Cellular Longevity (Web)  (Oxidative Med Cell Longev (Web))
Volume： 2018  Page： Null  Publication year： 2018 
JST Material Number： U7012A  ISSN： 1942-0900  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Mice that are deficient in sup...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=19A2049060&from=J-GLOBAL&jstjournalNo=U7012A") }}

Thesaurus term： therapy ,  oxidation ,  triglyceride ,  sensitivity ,  active oxygen ,  oxidative stress ,  *shake out ,  peroxidation ,  *Mus musculus ,  isoform ,  antioxidant enzyme ,  *Dyshepatia ,  *Superoxide Dismutase-1 ,  *peroxiredoxin 4 ,  *Myomorpha
Semi thesaurus term： 脂肪過剰 , 【Automatic Indexing@JST】

JST classification (2)： Basic medicine on digestive system  (GH01020E) ,  Basic research of drugs acting on digestive system  (GW09010Q)

Reference (44)：

• Y. Sumida, E. Niki, Y. Naito, T. Yoshikawa, "Involvement of free radicals and oxidative stress in NAFLD/NASH," Free Radical Research, vol. 47, no. 11, pp. 869-880, 2013.
• N. U. Ashraf, T. A. Sheikh, "Endoplasmic reticulum stress and oxidative stress in the pathogenesis of non-alcoholic fatty liver disease," Free Radical Research, vol. 49, no. 12, pp. 1405-1418, 2015.
• I. Fridovich, "Superoxide radical and superoxide dismutases," Annual Review of Biochemistry, vol. 64, no. 1, pp. 97-112, 1995.
• A. Okado-Matsumoto, I. Fridovich, "Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu,Zn-SOD in mitochondria," Journal of Biological Chemistry, vol. 276, no. 42, pp. 38388-38393, 2001.
• S. Elchuri, T. D. Oberley, W. Qi, R. S. Eisenstein, L. Jackson Roberts, H. van Remmen, C. J. Epstein, T. T. Huang, "CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life," Oncogene, vol. 24, no. 3, pp. 367-380, 2005.

Terms in the title (6)： マウス ,  ペルオキシレドキシン4 ,  スーパーオキシドジスムターゼ1 ,  SOD1 ,  ノックアウト ,  肝不全