Koide Shuhei

コイデシュウヘイ | Koide Shuhei

Affiliation and department：

Research field (3)： Molecular biology , Medical biochemistry , Hematology and oncology

Research keywords (6)：造血 , Epigenetics , Single cell analysis , Leukemia , Hematopoietic Stem Cell , Aging

Research theme for competitive and other funds (12)：

2024 - 2027 新規老化マーカーClusterinに基づく造血幹細胞老化機構の解明とその制御法の確立
2023 - 2024 分化障害型造血幹細胞の増幅様式
2023 - 2024 Alzheimer disease as a systematic disease driven by elevated Clusterin in hematopoietic stem cell
2023 - 2024 加齢に伴う造血幹細胞機能低下機序の解明
2022 - 2024 Elucidation of the principles of hematopoietic stem cells in aging and overcoming aging-related diseases

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Papers (55)：

Shintaro Watanuki, Hiroshi Kobayashi, Yuki Sugiura, Masamichi Yamamoto, Daiki Karigane, Kohei Shiroshita, Yuriko Sorimachi, Shinya Fujita, Takayuki Morikawa, Shuhei Koide, et al. Correction: Context-dependent modification of PFKFB3 in hematopoietic stem cells promotes anaerobic glycolysis and ensures stress hematopoiesis. eLife. 2024. 13
Satoshi Kaito, Kazumasa Aoyama, Motohiko Oshima, Akiho Tsuchiya, Makiko Miyota, Masayuki Yamashita, Shuhei Koide, Yaeko Nakajima-Takagi, Hiroko Kozuka-Hata, Masaaki Oyama, et al. Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization. Nature Communications. 2024. 15. 1
Naru Sato, Susumu Goyama, Yu-Hsuan Chang, Takeshi Fujino, Tamami Denda, Shuhei Asada, Shiori Shikata, Xiaoxiao Liu, Taishi Yonezawa, Reina Takeda, et al. CH-related Mutant ASXL1 Promotes Atherosclerosis in Mice via Dysregulated Innate Immunity. 2024
Yuki S Tateishi, Tamasa Araki, Satoru Kawai, Shuhei Koide, Yuko Umeki, Takashi Imai, Yumiko Saito-Nakano, Masaki Kikuchi, Atsushi Iwama, Hajime Hisaeda, et al. Histone H3.3 variant plays a critical role on zygote-to-oocyst development in malaria parasites. Parasitology international. 2024. 100. 102856-102856
Yaeko Nakajima-Takagi, Motohiko Oshima, Junichiro Takano, Shuhei Koide, Naoki Itokawa, Shun Uemura, Masayuki Yamashita, Shohei Andoh, Kazumasa Aoyama, Yusuke Isshiki, et al. Polycomb repressive complex 1.1 coordinates homeostatic and emergency myelopoiesis. eLife. 2023. 12

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MISC (47)：

海渡智史, 青山和正, 大島基彦, 中島やえ子, 小出周平, 山下真幸, 上野将也, 平尾敦, 通山薫, 岩間厚志. TOPORSの機能抑制はDNMT1の安定化を介してDNAメチル化阻害剤の効果を増強する. 日本血液学会学術集会. 2023. 85回. 286-286
大島基彦, 高山直也, 中島やえ子, 小出周平, 原田浩徳, 原田結花, Ding Ye, 明星智洋, 岩間厚志. 幹細胞分画を用いたクロマチン特性解析による骨髄異形成症候群の病態解明. 日本血液学会学術集会. 2023. 85回. 398-398
海渡智史, 青山和正, 大島基彦, 中島やえ子, 小出周平, 山下真幸, 上野将也, 平尾敦, 通山薫, 岩間厚志. TOPORSの機能抑制はDNMT1の安定化を介してDNAメチル化阻害剤の効果を増強する. 日本血液学会学術集会. 2023. 85回. 530-530
福田貴規, 中島やえ子, 青山和正, 小出周平, 山下真幸, 大島基彦, 岩間厚志. ポリコーム抑制複合体1.1は炎症性細胞死を抑制的に制御する. 日本血液学会学術集会. 2023. 85回. 565-565
神谷高博, 大島基彦, 小出周平, 中島やえ子, 青山和正, 海渡智史, 糸川直樹, 山下真幸, 土岐典子, 片岡圭亮, et al. シングルセルRNAシークエンスを用いた多発性骨髄腫の治療抵抗性に関わる不均一性の解明. 日本血液学会学術集会. 2023. 85回. 769-769

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Lectures and oral presentations (57)：

Polycomb repressive complex 1.1 negatively regulates inflammatory cell death
(2024)
Characterization of Multiple Myeloma Subpopulations Associated with Treatment Resistance By Single-Cell RNA Sequencing Characterization of Multiple Myeloma Subpopulations Associated with Treatment Resistance By Single-Cell RNA Sequencing
(2023)
Hematopoietic aging is regulated by the balance between two distinct hematopoietic stem cell populations
(2023)
Two distinctive hematopoietic stem cell populations coordinate hematopoietic aging
(2023)
Clu-positive hematopoietic stem cells show decreased stemness and expand with aging
(第84回日本血液学会 2022)

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Professional career (1)：

Ph.D (Chiba University)

Work history (7)：

2023/01 - 現在 The University of Tokyo
2019/04 - 2023/12 The University of Tokyo
2017/12 - 2019/03 Lund University
2017/12 - 2018/11 上原記念生命科学財団リサーチフェロー
2017/04 - 2017/11 千葉大学

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Awards (14)：

2023/06 - International Society for Experimental Hematology ISEH Travel Grant
2023/02 - 公益財団法人金原一郎医学医療振興財団第37回研究交流助成金
2023/02 - BioLegend Japan LEGEND Research Grant
2022/10 - 公益財団法人ライフサイエンス振興財団国際交流援助
2022/10 - American Society of Hematology Abstract Achievement Award

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Association Membership(s) (3)：

International Society for Experimental Hematology , THE JAPANESE BIOCHEMICAL SOCIETY , THE JAPANESE SOCIETY OF HEMATOLOGY

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