Tsuchiya Hikaru

Affiliation and department：
Homepage URL (1)： https://kaken.nii.ac.jp/ja/search/?kw=90760132

Research field (2)： Molecular biology , Functional biochemistry

Research keywords (3)： Protein degradation , Proteasome , Ubiquitin

Research theme for competitive and other funds (5)：

2023 - 2028 Integrated understanding of proteasomal degradation and the ubiquitin code
2020 - 2024 プロテアソーム結合ユビキチンリガーゼによるタンパク質分解制御
2017 - 2021 Elucidating the role of branched ubiquitin code
2018 - 2020 Elucidation of the proteasome activity by shuttle factors
2015 - 2017 A method for determining ubiquitin chain length in cells

Papers (26)：

Akinori Endo, Toshiaki Fukushima, Chikage Takahashi, Hikaru Tsuchiya, Fumiaki Ohtake, Sayaka Ono, Tony Ly, Yukiko Yoshida, Keiji Tanaka, Yasushi Saeki, et al. USP8 prevents aberrant NF-κB and Nrf2 activation by counteracting ubiquitin signals from endosomes. Journal of Cell Biology. 2024. 223. 3
Takumi Tsunoda, Miho Riku, Norika Yamada, Hikaru Tsuchiya, Takuya Tomita, Minako Suzuki, Mari Kizuki, Akihito Inoko, Hideaki Ito, Kenta Murotani, et al. ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer. EMBO reports. 2022. 23. 2. e51182
佐伯泰, 土屋光, 遠藤彬則. ケモテクノロジーが拓くユビキチンニューフロンティアケモプロテオミクスによるユビキチン-プロテアソーム系の理解(Understanding the ubiquitin-proteasome system by chemo-proteomics). 日本生化学会大会プログラム・講演要旨集. 2020. 93回. [2S01e-01]
Hikaru Tsuchiya, Akinori Endo, Yasushi Saeki. Multi-Step Ubiquitin Decoding Mechanism for Proteasomal Degradation. Pharmaceuticals (Basel, Switzerland). 2020. 13. 6
Sayaka Yasuda, Hikaru Tsuchiya, Ai Kaiho, Qiang Guo, Ken Ikeuchi, Akinori Endo, Naoko Arai, Fumiaki Ohtake, Shigeo Murata, Toshifumi Inada, et al. Stress- and ubiquitylation-dependent phase separation of the proteasome. Nature. 2020. 578. 7794. 296-300

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MISC (20)：

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Patents (2)：

Professional career (1)：

Work history (4)：

Awards (1)：

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