Tsuchiya Hikaru

Affiliation and department：
Homepage URL (1)： https://kaken.nii.ac.jp/ja/search/?kw=90760132

Research field (2)： Molecular biology , Functional biochemistry

Research keywords (4)：オートファジー , Protein degradation , Proteasome , Ubiquitin

Research theme for competitive and other funds (8)：

2024 - 2028 Functional Analysis of Atypical Ubiquitin Chains in Mammals
2023 - 2028 Integrated understanding of proteasomal degradation and the ubiquitin code
2022 - 2024 メゾ複雑体ユビキチン液滴が司るタンパク質分解
2020 - 2024 プロテアソーム結合ユビキチンリガーゼによるタンパク質分解制御
2017 - 2021 Elucidating the role of branched ubiquitin code

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Papers (27)：

Yukiko Yoshida, Tsuyoshi Takahashi, Nozomi Ishii, Ichiro Matsuo, Satoshi Takahashi, Haruka Inoue, Akinori Endo, Hikaru Tsuchiya, Meari Okada, Chikara Ando, et al. Sugar-mediated non-canonical ubiquitination impairs Nrf1/NFE2L1 activation. Molecular Cell. 2024. 84. 16. 3115-3127.e11
Akinori Endo, Toshiaki Fukushima, Chikage Takahashi, Hikaru Tsuchiya, Fumiaki Ohtake, Sayaka Ono, Tony Ly, Yukiko Yoshida, Keiji Tanaka, Yasushi Saeki, et al. USP8 prevents aberrant NF-κB and Nrf2 activation by counteracting ubiquitin signals from endosomes. Journal of Cell Biology. 2024. 223. 3
Takumi Tsunoda, Miho Riku, Norika Yamada, Hikaru Tsuchiya, Takuya Tomita, Minako Suzuki, Mari Kizuki, Akihito Inoko, Hideaki Ito, Kenta Murotani, et al. ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer. EMBO reports. 2022. 23. 2. e51182
佐伯泰, 土屋光, 遠藤彬則. ケモテクノロジーが拓くユビキチンニューフロンティアケモプロテオミクスによるユビキチン-プロテアソーム系の理解(Understanding the ubiquitin-proteasome system by chemo-proteomics). 日本生化学会大会プログラム・講演要旨集. 2020. 93回. [2S01e-01]
Hikaru Tsuchiya, Akinori Endo, Yasushi Saeki. Multi-Step Ubiquitin Decoding Mechanism for Proteasomal Degradation. Pharmaceuticals (Basel, Switzerland). 2020. 13. 6

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MISC (20)：

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Patents (2)：

Books (6)：

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Lectures and oral presentations (3)：

1. Ubiquitylation-dependent phase separation of the proteasome
(2023)
プロテアソーム液滴基質のプロテオーム解析
(日本プロテオーム学会2021年大会 2021)
In vivo ubiquitin linkage-type analysis reveals that the Cdc48-Rad23/Dsk2 axis contributes to K48-linked chain specificity of the proteasome
(International Protein Metabolism and Diseases Conference 2017)

Professional career (1)：

Work history (6)：

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Awards (3)：

Association Membership(s) (2)：

日本生化学会 , 日本分子生物学会

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