Rchr
J-GLOBAL ID：201901010056711695   Update date: May. 28, 2024

Nakata Kazuaki

ナカタ カズアキ | Nakata Kazuaki
Affiliation and department：
National Center for Global Health and Medicine

About National Center for Global Health and Medicine


Research field  (1)： Gastroenterology
Research keywords  (3)： Dietary lipids ,  intestinal epithelial cells ,  digestive tract
Research theme for competitive and other funds  (2)：
  • 2024 - 2026 食事中脂質クオリティーが組織恒常性維持機構に及ぼす影響とその破綻の分子機構の解明
  • 2020 - 2024 若年時の高脂肪食摂取が上皮バリア破綻をもたらす機構と疾患発症における意義の解明
Papers (6)：
  • Hiroaki Shiratori, Kisara M Hattori, Kazuaki Nakata, Takuma Okawa, Seiga Komiyama, Yusuke Kinashi, Yuma Kabumoto, Yuria Kaneko, Motoyoshi Nagai, Tomoko Shindo, et al. Purified diet affects intestinal epithelial proliferation and barrier functions through gut microbial alterations. International immunology. 2024
  • Hikari Narabayashi, Chiharu Koma, Kazuaki Nakata, Mion Ikegami, Yusuke Nakanishi, Jun Ogihara, Masato Tsuda, Akira Hosono, Shigemasa Hanazawa, Kyoko Takahashi. Gut microbiota-dependent adaptor molecule recruits DNA methyltransferase to the TLR4 gene in colonic epithelial cells to suppress inflammatory reactions. Frontiers in molecular biosciences. 2022. 9. 1005136-1005136
  • Ryusuke Sumiya, Masayoshi Terayama, Teruki Hagiwara, Kazuaki Nakata, Keigo Sekihara, Satoshi Nagasaka, Hideki Miyazaki, Toru Igari, Kazuhiko Yamada, Yuki I Kawamura. Loss of GSTO2 contributes to cell growth and mitochondria function via the p38 signaling in lung squamous cell carcinoma. Cancer science. 2022. 113. 1. 195-204
  • Kazuaki Nakata, Yutaka Sugi, Hikari Narabayashi, Tetsuro Kobayakawa, Yusuke Nakanishi, Masato Tsuda, Akira Hosono, Shuichi Kaminogawa, Shigemasa Hanazawa, Kyoko Takahashi. Commensal microbiota-induced microRNA modulates intestinal epithelial permeability through the small GTPase ARF4. JOURNAL OF BIOLOGICAL CHEMISTRY. 2017. 292. 37. 15426-15433
  • Yutaka Sugi, Kyoko Takahashi, Kenta Kurihara, Kou Nakano, Tetsuro Kobayakawa, Kazuaki Nakata, Masato Tsuda, Shigemasa Hanazawa, Akira Hosono, Shuichi Kaminogawa. alpha-Defensin 5 gene expression is regulated by gut microbial metabolites. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY. 2017. 81. 2. 242-248
ｍore...
Lectures and oral presentations  (6)：
  • DIETARY STEARIC ACID PROMOTES EPITHELIAL CELL PROLIFERATION AND TUMORIGENESIS IN THE INTESTINE VIA FATTY ACID-BINDING PROTEIN 5 UNCOUPLED WITH THE OBESE PHENOTYPE
    (Digestive Disease Week 2024 2024)
  • 食事由来脂質クオリティが腸管腫瘍リスクに及ぼす影響
    (国立高度専門医療研究センター 医療研究連携推進本部 合同リトリート 2024)
  • Impact of dietary fatty acid on intestinal tumorigenesis
    (THE 82ND ANNUAL MEETING OF THE JAPANESE CANCER ASSOCIATION 2023)
  • 食事由来脂質クオリティが腸管腫瘍リスクに及ぼす影響
    (国立高度専門医療研究センター 医療研究連携推進本部 合同リトリート 2023)
  • 食餌性脂肪酸が腸上皮恒常性維持機構ならびに消化器疾患へ及ぼす影響
    (日本食品免疫学会 第18回学術大会 2022)
ｍore...
Education (1)：
  • 2016 - 2019 日本大学 生物資源科学研究科 応用生命科学専攻 博士後期課程
Professional career (1)：
  • 生物資源科学 (日本大学)
Work history (3)：
  • 2023/07 - 現在 National Center for Global Health and Medicine
  • 2022/05 - 現在 国立研究開発法人国立国際医療研究センター研究所 共通実験室 研究員
  • 2019/04 - 現在 国立研究開発法人国立国際医療研究センター国府台病院 肝炎・免疫研究センター消化器疾患研究部 研究員
Awards (2)：
  • 2023/04 - Japan Health Research Promotion Bureau Chairman's Award
  • 2014/09 - The joint Meeting of the XVIII International Symposium on Gnotobiology (XVIII-ISG) and III International Ecological Forum “Environmental and human health” (EcoForum) Marie E Coates Award to BEST POSTER FROM A YOUNG SCIENTIST at XVIII International Symposium on Gnotobiology The commensal bacteria and short chain fatty acids affect to immunoglobulin A production by the immune cells derived from the gut associated lymphoid tissues in small and large intestines
Association Membership(s) (4)：
日本癌学会 ,  THE JAPANESE SOCIETY FOR IMMUNOLOGY ,  日本食品免疫学会 ,  JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY
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