Rchr
J-GLOBAL ID：201901010474232493
Update date: Feb. 01, 2024
Hiroshi Kobayashi
コバヤシ ヒロシ | Hiroshi Kobayashi
Affiliation and department：
Job title：
Professor
Research field (2)：
Fetal medicine/Pediatrics
, Metabolism and endocrinology
Research keywords (5)：
AI
, Lentiviral vector
, inherited error of metabolism
, Lysosomal storage disease
, gene therapy
Research theme for competitive and other funds (23)：
- 2021 - 2026 BBB通過型GALC発現AAVベクターはクラッベ病マウスの寿命延長効果を持つか
- 2021 - 2024 早期難聴発症モデルにおける内耳障害の病態メカニズムの解明と予防法の開発
- 2021 - 2024 ヒト型受容体介在性トランスサイトーシスを利用したライソゾーム病遺伝子治療法の開発
- 2019 - 2022 細胞送達能を高めた改変型酵素を用いるムコ多糖症II型の造血幹細胞遺伝子治療法開発
- 2018 - 2021 Development of Hematopoietic Stem Targeted Gene Therapy for GM1-gangliosidosis
- 2018 - 2021 Integrated database construction of Fabry disease using artificial intelligence / next generation sequencer
- 2015 - 2019 Preparation of device for mucopolysaccharidosis treatment using iPS cells and gene modification system
- 2015 - 2018 Development of efficient enzyme replacement therapy for lysosomal storage disease with immune modulation
- 2015 - 2018 Improvement of peripheral neuropathy by Adeno-associated virus vector expressing a-galactosidase A in murine Fabry model
- 2014 - 2017 Analysis of the Pathophysiological Mechanism of Bone Lesion in Mucopolysaccharidosis Mouse Model ; Its Natural History and Therapeutic Effect
- 2012 - 2016 Development of effective treatment by immune tolerance induction in enzyme replacement therapy for lysosomal storage diseases
- 2012 - 2015 Gene Therapy for the Krabbe disease using zinc finger nuclease system
- 2011 - 2015 Developping of the genetherapy for Fabry's disesase mouse using the newly designed peptide vector
- 2009 - 2011 Anti-CD3 antibody induced immune tolerance to infused enzyme in enzyme replacement therapy for lysosomal storage disease
- 2008 - 2010 Lentiviral vector mediated gene therapy for Krabbe disease
- 2007 - 2008 Immune tolerance induction in enzyme replacement therapy for lysosomal storage diseases
- 2001 - 2002 シュードタイプ・バキュウロウイルスベクターを用いたSly病マウスの遺伝子治療
- 1999 - 2000 Gene therapy for Krabbe disease with microglial cells derived from brain
- 1999 - 2000 Gene Therapy for Sly disease using AAV vector.
- 1999 - 2000 Treatment for congenital metabolic disorder with brain dysfunction.
- 1999 - 2000 シュードタイプ・バキュウロウイルスベクターを用いたSly病マウスの遺伝子治療
- 1997 - 1998 Gene therapy for Sly disease
- 1996 - 1996 筋肉細胞を標的としたリソゾーム蓄積症の遺伝子治療の開発
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Papers (58)：
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Yohta Shimada, Natsumi Ishii, Takashi Higuchi, Motohito Goto, Toya Ohashi, Hiroshi Kobayashi. A novel preclinical model of mucopolysaccharidosis type II for developing human hematopoietic stem cell gene therapy. Gene therapy. 2022
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Toshiki Tsunogai, Toya Ohashi, Yohta Shimada, Takashi Higuchi, Ayaka Kimura, Ayako M Watabe, Fusao Kato, Hiroyuki Ida, Hiroshi Kobayashi. Hematopoietic stem cell gene therapy ameliorates CNS involvement in murine model of GM1-gangliosidosis. Molecular therapy. Methods & clinical development. 2022. 25. 448-460
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Ikuko Anan, Toru Sakuma, Eiko Fukuro, Satoshi Morimoto, Ayumi Nojiri, Makoto Kawai, Ken Sakurai, Masahisa Kobayashi, Hiroshi Kobayashi, Hiroyuki Ida, et al. The role of native T1 values on the evaluation of cardiac manifestation in Japanese Fabry disease patients. Molecular genetics and metabolism reports. 2022. 31. 100858-100858
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角皆 季樹, 大橋 十也, 嶋田 洋太, 樋口 孝, 木村 文香, 松島 小貴, 渡部 文子, 小林 博司. 造血幹細胞を標的としたレンチウイルスベクターを用いたGM1ガングリオシドーシスの遺伝子治療法の開発. 東京慈恵会医科大学雑誌. 2021. 136. 6. 136-137
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Yuta Koto, Norio Sakai, Yoko Lee, Naoko Kakee, Junko Matsuda, Kazuya Tsuboi, Nobuyuki Shimozawa, Torayuki Okuyama, Kimitoshi Nakamura, Aya Narita, et al. Prevalence of patients with lysosomal storage disorders and peroxisomal disorders: A nationwide survey in Japan. Molecular genetics and metabolism. 2021. 133. 3. 277-288
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MISC (14)：
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嶋田 洋太, 石井 夏実, 後藤 元人, 樋口 孝, 小林 博司, 大橋 十也. ヒト造血幹細胞の移植が可能な新たなムコ多糖症II型モデルマウスの樹立. 日本先天代謝異常学会雑誌. 2018. 34. 175-175
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Yohei Sato, Hiroshi Kobayashi, Yohta Shimada, Hiroyuki Ida, Yoshikatsu Eto, Toya Ohashi. Direct Reprogramming of Fibroblast Allows Live-Cell Imaging of Autophagic Buildup in Pompe Disease Skeletal Myoblast. MOLECULAR THERAPY. 2015. 23. S149-S149
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Lentiviral ex-vivo gene therapy in a murine model of mucopolysaccharidosis type 2. 2014. 129. 6. 229-229
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Taichi Wakabayashi, Yohta Shimada, Takashi Higuchi, Hiroshi Kobayashi, Hiroyuki Ida, Toya Ohashi. Ex vivo gene therapy improves the accumulation of glycosaminoglycans in brain from murine model of mucopolysaccharidosis type II. GLYCOBIOLOGY. 2014. 24. 11. 1214-1214
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Yohta Shimada, Taichi Wakabayashi, Kazumasa Akiyama, Takashi Higuchi, Hiroshi Kobayashi, Yoshikatsu Eto, Hiroyuki Ida, Toya Ohashi. Development of novel method for analysis of disease-specific glycosaminoglycans in mucopolysaccharidosis type II. GLYCOBIOLOGY. 2014. 24. 11. 1210-1210
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Patents (1)：
Association Membership(s) (4)：
日本小児科学会
, American Society of Gene and Cell Therapy
, 日本先天代謝異常学会
, 日本遺伝子細胞治療学会
