Rchr
J-GLOBAL ID：201901012607204415
Update date: Apr. 24, 2024
Yasuyuki Miyake
ミヤケ ヤスユキ | Yasuyuki Miyake
Affiliation and department：
Job title：
Designated associate professor
Research field (4)：
Structural biochemistry
, Genetics
, Molecular biology
, Virology
Research keywords (6)：
Ubiquitin
, RNA virus
, Histone Deacetylase
, influenza virus
, molecular function
, molecular structure
Research theme for competitive and other funds (4)：
- 2021 - 2024 ウイルス感染における宿主因子の動態と分子機能の解明
- 2020 - 2023 Molecular mechanism of influenza A virus and HIV-1 uncoating
- 2020 - 2023 The HDAC6/USP7 axis in enveloped RNA virus infection
- 2018 - 2020 Molecular mechanism of influenza A virus uncoating by ubiquitin chains
Papers (9)：
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Longlong Wang, Etori Aguiar Moreira, Georg Kempf, Yasuyuki Miyake, Blandina I. Oliveira Esteves, Amal Fahmi, Jonas V. Schaefer, Birgit Dreier, Yohei Yamauchi, Marco P. Alves, et al. Disrupting the HDAC6-ubiquitin interaction impairs infection by influenza and Zika virus and cellular stress pathways. Cell Reports. 2022. 39. 4. 110736-110736
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Shouhei Miyagi, Takahiro Watanabe, Yuya Hara, Masataka Arata, Md. Kamal Uddin, Keisuke Mantoku, Ken Sago, Yusuke Yanagi, Takeshi Suzuki, H. M. Abdullah Al Masud, et al. A STING inhibitor suppresses EBV-induced B cell transformation and lymphomagenesis. Cancer Science. 2021. 112. 12. 5088-5099
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Miyake Y, Keusch JJ, Decamps L, Ho-Xuan H, Iketani S, Gut H, Kutay U, Helenius A, Yamauchi Y. Influenza virus uses transportin 1 for vRNP debundling during cell entry. Nature Microbiology. 2019. 4. 578-586
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Yasuyuki Miyake, Jeremy J. Keusch, Longlong Wang, Makoto Saito, Daniel Hess, Xiaoning Wang, Bruce J. Melancon, Paul Helquist, Heinz Gut, Patrick Matthias. Structural insights into HDAC6 tubulin deacetylation and its selective inhibition. NATURE CHEMICAL BIOLOGY. 2016. 12. 9. 748-+
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Christian Scholz, Brian T. Weinert, Sebastian A. Wagner, Petra Beli, Yasuyuki Miyake, Jun Qi, Lars J. Jensen, Werner Streicher, Anna R. McCarthy, Nicholas J. Westwood, et al. Acetylation site specificities of lysine deacetylase inhibitors in human cells. NATURE BIOTECHNOLOGY. 2015. 33. 4. 415-U136
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MISC (6)：
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佐藤好隆, 渡辺崇広, 三宅康之, 木村 宏. 重症ウイルス感染症/ウイルス関連腫瘍を制御するための宿主因子探索と創薬応用. 最先端ナノライフシステム研究. 2022. 24-29
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Miyake Y, Matthias P, Yamauchi Y. Purification of Unanchored Polyubiquitin Chains from Influenza Virions. Methods in Molecular Biology. 2018. 1836. 329-342
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Christian Schoelz, Brian Weinert, Sebastian Wagner, Petra Beli, Yasuyuki Miyake, Jun Qi, Lars Jensen, Werner Streicher, Anna McCarthy, Nicholas Westwood, et al. Insigths into the acetylation pattern of HDAC inhibitors and their potential role in HIV therapy. RETROVIROLOGY. 2016. 13
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三宅 康之, パトリック マティアス. ヒストン脱アセチル化酵素HDAC6の結晶構造から明らかにされたチューブリンに対する特異性および選択的な阻害剤との結合. ライフサイエンス新着論文レビュー. 2016
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Takeshi Mizuno, Christian Eichinger, Ken-Ichiro Yanagi, Yasuyuki Miyake, Fumio Hanaoka. Sequestering of aberrant DNA polymerase a in the cytoplasm suggests the presence of a quality control mechanism. CELL STRUCTURE AND FUNCTION. 2005. 30. 39-39
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Patents (1)：
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New treatment against influenza virus
Books (3)：
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Influenza A Virus: Cellular Entry
Springer 2023
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インフルエンザウイルスの細胞内侵入の生化学
日本生化学会 2022
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Molecular function of host factors involved in cellular entry of influenza A virus
2022
Lectures and oral presentations (12)：
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Role of endosomal acidification in RNA virus uncoating
(The 46th Annual Meeting of the Molecular Biology Society of Japan 2023)
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Molecular insights into the assembly and debundling of vRNPs of influenza A virus
(2023)
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Host deubiquitinating enzyme USP7 and histone deacetylase HDAC6 function during uncoating of influenza A virus
(The 70th Annual Meeting of the Japanese Society for Virology 2023)
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Molecular mechanisms of uncoating in human coronavirus 229E
(2022)
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宿主タンパク質を介したウイルス脱殻反応の分子機構解明
(第69回日本ウイルス学会学術集会 2022)
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Professional career (1)：
Work history (6)：
Awards (2)：
- 2019/01 - University of Bristol CMM Awayday Best Poster Prize Influenza virus uses transportin 1 for vRNP debundling during cell entry
- 2016/01 - Pfizer Pfizer Forschungspreis Infektiologie, Rheumatologie, und Immunologie
Association Membership(s) (3)：
日本細胞生物学会
, 日本ウイルス学会
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
