Ohashi Wakana

オオハシワカナ | Ohashi Wakana

Affiliation and department：
Job title： Associate Professor

Research field (4)： Laboratory animal science , Molecular biology , Immunology , Pharmacology

Research keywords (2)： gut immunity , Microbiome

Research theme for competitive and other funds (7)：

2023 - 2028 Elucidation of mucosal barrier regulation by intestinal microbiota
2020 - 2023 亜鉛トランスポーターを介した代謝制御機構の解明に基づく大腸がん治療戦略の創出
2017 - 2020 腫瘍領域に高発現する亜鉛トランスポーターの役割解明と治療標的としての可能性の探求
2017 - 2020 敗血症性播種性血管内凝固(DIC)の分子病態解明に基づいた予防法・治療法の創出
2015 - 2017 亜鉛トランスポーターによる腸管上皮幹細胞維持機構の解明

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Papers (34)：

Atsuo Nakamura, Shin Kurihara, Daisuke Takahashi, Wakana Ohashi, Yutaka Nakamura, Shunsuke Kimura, Masayoshi Onuki, Aiko Kume, Yukiko Sasazawa, Yukihiro Furusawa, et al. Symbiotic polyamine metabolism regulates epithelial proliferation and macrophage differentiation in the colon. Nature Communications. 2021. 12. 1
Keigo Nishida, Aiko Hasegawa, Satoru Yamasaki, Ryota Uchida, Wakana Ohashi, Yosuke Kurashima, Jun Kunisawa, Shunsuke Kimura, Toshihiko Iwanaga, Hiroshi Watarai, et al. Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis. Scientific reports. 2019. 9. 1. 10842-10842
Palikhe S, Ohashi W, Sakamoto T, Hattori K, Kawakami M, Andoh T, Yamazaki H, Hattori Y. Regulatory role of GRK2 in the TLR signaling-mediated iNOS induction pathway in microglial cells. Frontiers in Pharmacology. 2019. 4. 10. 59
Ohashi W, Fukada T. Contribution of zinc and zinc transporters in the pathogenesis of inflammatory bowel diseases. Journal of Immunological Research. 2019. 2019. 8396878
Ohashi W, Hara T, Takagishi T, Hase K, Fukada T. Maintenance of intestinal epithelial homeostasis by zinc transporters. Digestive Diseases and Sciences. 2019. 4

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MISC (14)：

Hiroki Misawa, Wakana Ohashi, Kengo Tomita, Yutaka Shimada, Yuichi Hattori. The hepatoprotective effects of prostacyclin mimetics are associated with their anti-oxidative actions. FASEB JOURNAL. 2017. 31
Wakana Ohashi, Koji Hase, Toshiyuki Fukada. Zinc Transporter SLC39A7/ZIP7 Is Essential for Intestinal Homeostatic Self-Renewal. GASTROENTEROLOGY. 2016. 150. 4. S138-S138
Mizuki Hattori, Wakana Ohashi, Mitsuaki Yamazaki, Yuichi Hattori. Histamine serves as an aggravating factor in major end-organ injury associated with sepsis. FASEB JOURNAL. 2016. 30
Hiroki Misawa, Wakana Ohashi, Yutaka Shimada, Yuichi Hattori. Protective effect of ONO-1301, a long-acting prostacyclin agonist, on lipopolysaccharide/D-galactosamine-induced liver injury. FASEB JOURNAL. 2016. 30
Wakana Ohashi. The role of Zinc transporter in the maintenance of intestinal epithelial homeostasis. Journal of Zinc Nutritional Therapy. 2016. 7. 1

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Professional career (1)：

Ph.D

Work history (8)：

2023/06 - 現在 University of Shizuoka Laboratory of Microbiology and Immunology Associate Professor
2020/04 - 2023/05 Keio University Division of Biochemistry, Faculty of Pharmacy Lecturer
2019/12 - 2020/03 University of Toyama Department of Diagnostic pathology, Faculty of Medicine Academic Assembly Assistant Professor
2013/04 - 2019/11 University of Toyama Department of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences for Research Assistant Professor
2011/04 - 2013/03 RIKEN Laboratory for Cytokine Signaling, Research Center for Allergy and Immunology Research Scientist

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Committee career (6)：

2017 - 現在トランスポーター研究会世話人
2017 - 現在日本亜鉛栄養治療研究会世話人
2018 - 2020 日本生化学会北陸支部幹事
2018 - 2018 日本薬理学会第68回日本薬理学会北部会実行委員
2015 - 2016 日本薬学会ファルマシアトピックス小委員

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Awards (1)：

2016/12 - 第39回日本分子生物学会優秀ポスター賞亜鉛トランスポーターによる小胞体ストレスと腸管上皮恒常性の制御機構

Association Membership(s) (7)：

Japan Transporter Research Association , Japanese Society for Zinc Nutritional Therapy , JAPAN SOCIETY FOR BIOMEDICAL RESEARCH ON TRACE ELEMENTS , THE JAPANESE BIOCHEMICAL SOCIETY , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE SOCIETY FOR IMMUNOLOGY , THE JAPANESE PHARMACOLOGICAL SOCIETY

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