Suenaga Yusuke

Affiliation and department：
Job title： Laboratory Head
Homepage URL (1)： https://www.pref.chiba.lg.jp/gan/kenkyujo/departments/et.html

Research field (1)： Tumor biology

Research keywords (12)：分子進化 , 神経内分泌腫瘍 , MYC , 転写 , TLP , p53 , p63 , 遺伝子誕生 , MYCN , 神経芽腫 , NCYM , de novo gene

Research theme for competitive and other funds (22)：

2024 - 2028 子宮内膜発がんにおける多段階発がんとがん多様性創出の分子機構解明
2024 - 2027 NCYMによるオートファジー制御とその胆管発がんへの寄与の解明
2023 - 2026 Elucidation of MYCN/NCYM function in outer radial glial cell
2023 - 2026 Usefulness of ORF dominance as a novel biomarker in cholangiopancreatic cancer
2022 - 2025 オルガノイドを活用したPTEN遺伝子VUSの新規評価法の確立

Show all

Papers (42)：

Nadzifa Nugraheni, Ummi Maryam Zulfin, Beni Lestari, Novia Permata Hapsari, Muthi Ikawati, Rohmad Yudi Utomo, Yusuke Suenaga, Yoshitaka Hippo, Edy Meiyanto. PGV-1 causes disarrangement of spindle microtubule organization resulting in aberrant mitosis in HLF and HuH6 cells associated with altered MYCN status. Advanced Pharmaceutical Bulletin. 2024
Meiyanto, E, Moordiani, M, Novitasari, D, Novitasari, D, Susidarti, R. A, Ikawati, M, Kato, J.-Y, Hippo, Y, Suenaga, Y. Pentagamavunone-1 suppresses MYCN-positive HuH-7 Cancer Cell Growth via Mitotic Arrest in vitro (accepted). Indonesian Journal of Pharmacy. 2024
Assia Mouhand, Kazuma Nakatani, Fumiaki Kono, Yoshitaka Hippo, Tatsuhito Matsuo, Philippe Barthe, Judith Peters, Yusuke Suenaga, Taro Tamada, Christian Roumestand. 1H, 13C and 15N backbone and side-chain resonance assignments of the human oncogenic protein NCYM. Biomolecular NMR assignments. 2024
Kazuma Nakatani, Hiroyuki Kogashi, Takanori Miyamoto, Taiki Setoguchi, Tetsushi Sakuma, Kazuto Kugou, Yoshinori Hasegawa, Takashi Yamamoto, Yoshitaka Hippo, Yusuke Suenaga. Inhibition of OCT4 binding at the MYCN locus induces neuroblastoma cell death accompanied by downregulation of transcripts with high-open reading frame dominance. Frontiers in oncology. 2024. 14. 1237378-1237378
Kiyohiro Ando, Yusuke Suenaga, Takehiko Kamijo. DNA Ligase 4 Contributes to Cell Proliferation against DNA-PK Inhibition in MYCN-Amplified Neuroblastoma IMR32 Cells. International Journal of Molecular Sciences. 2023. 24. 10. 9012-9012

ｍore...

MISC (29)：

山本清義, 中谷一真, 河野史明, 松尾龍人, 玉田太郎, 筆宝義隆, 末永雄介. Single molecule observation of DNA aptamers targeting de novo protein NCYM. 日本癌学会学術総会抄録集(Web). 2023. 82nd
古樫浩之, 中谷一真, ジェイソン・リン, 河津正人, 筆宝義隆, 末永雄介. 新しいクラスの腫瘍マーカー、オープンリーディングフレームドミナンス(ORF-D)(The open reading frame dominance index(ORF-D) as a novel class of the tumor marker). 日本癌学会総会記事. 2022. 81回. E-2012
古樫浩之, 中谷一真, ジェイソン・リン, 河津正人, 筆宝義隆, 末永雄介. 新しいクラスの腫瘍マーカー、オープンリーディングフレームドミナンス(ORF-D)(The open reading frame dominance index(ORF-D) as a novel class of the tumor marker). 日本癌学会総会記事. 2022. 81回. P-2001
末永雄介, 古樫浩之, 中谷一真, ジェイソン・リン, 河津正人, 加藤護, 永井桃子, 筆宝義隆. 新規coding遺伝子の誕生を正確にとらえる指標ORFドミナンスの計算によるがん進化の解析(Dissecting cancer evolution by calculating the ORF dominance index that captures the birth of novel coding genes). 日本癌学会総会記事. 2022. 81回. E-3043
中谷一真, 中谷一真, 松尾龍人, 松尾光一, 玉田太郎, 末永雄介. Identification of amino acid residues that modulate NCYM function using protein perdeuteration. 日本癌学会学術総会抄録集(Web). 2022. 81st

ｍore...

Patents (2)：

Books (5)：

Evolutionary biology of tumor initiation and progression
Lausanne: Frontiers Media SA. 2024 ISBN:9782832550991
Molecular Mechanisms and Treatment of MYCN-driven Tumors
Lausanne: Frontiers Media SA 2022
がん生物学イラストレイテッド第2版
羊土社 2019 ISBN:9784758120968
再発見!MYCの多機能性グローバル転写因子として見直される古典的がん遺伝子
2018
がん生物学イラストレイテッド
羊土社 2011 ISBN:9784758120210

Lectures and oral presentations (18)：

患者由来胆管癌オルガノイドを用いたNCYM標的薬の開発
(日本患者由来がんモデル学会日本人細胞学会合同学術集会2024 2024)
胆管癌オルガノイドを用いたNCYM標的薬の開発
(第10回細胞凝集研究会、佐賀 2024)
生物学科出身のアイデンティティを活かしたがん研究
(進路研究2023 講演会、千葉大学理学部生物学科 2023)
Gene birth and alternation of ORF dominance during cancer evolution
(KINYO-KAI, NIH Japanese Fellow Meeting, NIH Building 37, Bethesda, USA 2023)
Targeting de novo gene NCYM for cancer therapy
(The Society for Molecular Biology and Evolution Satellite Meeting on De Novo Gene Birth, Texas A&M University, USA 2023)

ｍore...

Education (4)：

2007 - 2010 Chiba University Graduate School of Medical and Pharmaceutical Sciences
2010 - Chiba University Graduate School of Medical and Pharmaceutical Sciences
2005 - 2007 Chiba University Graduate School of Medical and Pharmaceutical Sciences
2001 - 2005 Chiba University Faculty of Science Department of Biology

Work history (9)：

2024/04 - 現在 Laboratory of Evolutionary Oncology, Chiba Cancer Center Research Institute Laboratory Head
2023/04 - 2024/03 Laboratory of Evolutionary Oncology, Chiba Cancer Center Research Institute Senior Researcher
2022/04 - 2023/03 千葉県がんセンター研究所発がん制御研究部上席研究員
2018/04 - 2022/03 Chiba Cancer Center
2017/01 - 2020/03 東京理科大学薬学部生命創薬科学科客員准教授

Show all

Committee career (5)：

2021/09 - 現在 Frontiers in Oncology Associate Editor
2021/03 - 現在 International Journal of Molecular Sciences Topics Board Editor
2017/09 - 2023/04 Royal Society of Medicine (London) Overseas Fellow
2020/08 - Frontiers in Pediatrics Guest Editor
2013/09 - The Local Organization Committee of the 6th p63/p73 International Workshop Committee Member

Association Membership(s) (5)：

日本がん分子標的治療学会 , 日本生化学会 , 日本分子生物学会 , 日本癌学会 , Royal Society of Medicine

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page