Rchr
J-GLOBAL ID:201901021108814643   Update date: Jun. 01, 2024

Sekiya Hiroshi

Sekiya Hiroshi
Affiliation and department:
Research field  (2): Pharmaceuticals - health and biochemistry ,  Bacteriology
Research keywords  (5): ディフィシル菌 ,  抗菌薬 ,  薬剤耐性 ,  ウェルシュ菌 ,  溶菌酵素
Research theme for competitive and other funds  (5):
  • 2022 - 2025 ディフィシル菌溶菌酵素の菌種特異性に関する分子メカニズムの解明
  • 2022 - 2025 ファージ吸着分子結合マイクロ粒子を利用した抗C. difficile治療法の創出
  • 2017 - 2020 Psmの種特異性に関する分子メカニズムの解明
  • 2009 - 2010 Acinetobacter baumanniiの未解析多剤排出ポンプの機能解析 研究課題
  • 2007 - 2008 緑膿菌の多剤排出ポンプMexHI-OpmDの解析 研究課題
Papers (25):
  • Hiroshi Sekiya, Yasuhiro Nonaka, Shigehiro Kamitori, Tomomi Miyaji, Eiji Tamai. X-ray structure and mutagenesis analyses of Clostridioides difficile endolysin Ecd09610 glucosaminidase domain. Biochemical and Biophysical Research Communications. 2024
  • Hiroshi Sekiya, Saki Kobayashi, Ikumi Takahashi, Shigehiro Kamitori, Eiji Tamai. Biochemical Characterizations of the Putative Amidase Endolysin Ecd18980 Catalytic Domain from <i>Clostridioides difficile</i>. Biological and Pharmaceutical Bulletin. 2023. 46. 11. 1625-1629
  • Eiji Tamai, Mitsugu Yamada, Takuya Ishida, Nayu Arimura, Risa Matsunami, Hiroshi Sekiya, Shigehiro Kamitori. Structural and biochemical characterization of Clostridium perfringens pili protein B collagen-binding domains. FEBS letters. 2023
  • Hiroshi Sekiya, Hina Yamaji, Ayumi Yoshida, Risa Matsunami, Shigehiro Kamitori, Eiji Tamai. Biochemical Characterizations of the Putative Endolysin Ecd09610 Catalytic Domain from Clostridioides difficile. Antibiotics (Basel, Switzerland). 2022. 11. 8
  • Hiroshi Sekiya, Shigehiro Kamitori, Hirofumi Nariya, Risa Matsunami, Eiji Tamai. Structural and biochemical characterization of the Clostridium perfringens-specific Zn2+-dependent amidase endolysin, Psa, catalytic domain. Biochemical and biophysical research communications. 2021. 576. 66-72
more...
MISC (59):
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Lectures and oral presentations  (8):
  • ディフィシル菌のエンドペプチダーゼAcd24020の機能解析
    (第73回日本細菌学会中国・四国支部総会 2020)
  • C. difficileのエンドペプチダーゼCD630_11350の生化学的解析
    (第72回日本細菌学会中国・四国支部総会 2019)
  • 含フッ素benzoxazole誘導体及びその金属錯体の抗菌作用
    (第70回日本細菌学会中国・四国支部総会 2017)
  • 溶菌酵素Psmの腸内常在菌に対する作用および変異体解析
    (第69回日本細菌学会中国・四国支部総会 2016)
  • 溶菌酵素Psmにおける細胞壁結合ドメイン変異体の解析
    (第68回日本細菌学会中国・四国支部総会 2015)
more...
Education (3):
  • 2004 - 2007 Okayama University
  • 2002 - 2004 Okayama University The Graduate School of Natural Science and Technology
  • 1998 - 2002 Okayama University Faculty of Pharmaceutical Sciences
Professional career (1):
  • 博士(薬学) (岡山大学)
Work history (2):
  • 2021/04 - 現在 松山大学薬学部感染症学 講師
  • 2007/04 - 2021/03 Matsuyama University Faculty of Pharmaceutical Sciences
Association Membership(s) (2):
THE PHARMACEUTICAL SOCIETY OF JAPAN ,  JAPANESE SOCIETY FOR BACTERIOLOGY
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