YOKOO HIDETOMO

ヨコオヒデトモ | YOKOO HIDETOMO

Affiliation and department：
Job title： Researcher
Research theme for competitive and other funds (4)：

2024 - 2027 様々なユビキチンリガーゼを巧みに利用した分解誘導剤の開発
2022 - 2025 ナノ粒子型タンパク質分解誘導剤の活用
2022 - 2024 Development of cell-penetrating E3 ligase ligand and its application to nanoparticle-based degraders.
2020 - 2022 Development of degrader targeting proteins regulated by ubiquitination

Papers (45)：

Hanqiao Xu, Nobumichi Ohoka, Takao Inoue, Hidetomo Yokoo, Yosuke Demizu. Photo-regulated PROTACs: A novel tool for temporal control of targeted protein degradation. Bioorganic & medicinal chemistry letters. 2024. 107. 129778-129778
Zhou Dongrui, Maho Miyamoto, Hidetomo Yokoo, Yosuke Demizu. Innovative peptide architectures: advancements in foldamers and stapled peptides for drug discovery. Expert opinion on drug discovery. 2024. 1-25
Hidetomo Yokoo, Genichiro Tsuji, Takao Inoue, Mikihiko Naito, Yosuke Demizu, Nobumichi Ohoka. Expansion of targeted degradation by Gilteritinib-Warheaded PROTACs to ALK fusion proteins. Bioorganic chemistry. 2024. 145. 107204-107204
Miki Suzuki, Yuki Mochida, Mao Hori, Akimasa Hayashi, Kazuko Toh, Theofilus A. Tockary, Xueying Liu, Victor Marx, Hidetomo Yokoo, Kanjiro Miyata, et al. Poly(ethylene Glycol) (PEG)-OligoRNA Hybridization to mRNA Enables Fine-Tuned Polyplex PEGylation for Spleen-Targeted mRNA Delivery. Small Science. 2024
Hidetomo Yokoo, Yoshitaka Aoyama, Takashi Matsumoto, Eiichi Yamamoto, Nahoko Uchiyama, Yosuke Demizu. Rapid Structure Determination of Ranitidine Hydrochloride API in Two Crystal Forms Using Microcrystal Electron Diffraction. Chemical & pharmaceutical bulletin. 2024. 72. 5. 471-474

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MISC (5)：

平野智也, 横尾英知, 影近弘之. 蛍光性天然物を基にした新規蛍光物質の創製. 有機合成協会誌. 2022. 80. 922-929
Hidetomo Yokoo. Peptide and Protein Delivery. Wiley-VCH, Cell-Penetrating Peptides.Design, Development and Applications. 2022. Chapter 13
Design and synthetic strategies for TPD drug discovery. 2021. 53. 3. 148-151
Tomoya Hirano, Hidetomo Yokoo, Ayumi Ohsaki, Hiroyuki Kagechika. Development of Novel Fluorescent Sensors Based on Fluorescent Natural Compounds. Biomedical Engineering. 2021. Chapter 6
横尾英知, 出水庸介. TPD創薬への有機化学的アプローチ. ファルマシア(Web). 2021. 57. 7

Education (3)：

2016 - 2019 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Track of Life Science and Technology
2014 - 2016 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Track of Medical and Dental Science and Technology
2010 - 2014 Saitama University Faculty of Science Department of Chemistry

Professional career (1)：

Work history (10)：

2023/04 - 現在 Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion Visiting Scientist
2023/03 - 現在 National Institute of Health Sciences Division of Organic Chemistry Researcher
2023/03 - 現在 Kyoto Prefectural University of Medicine Graduate School of Medical Science
2022/04 - 2023/02 Kyoto Prefectural University of Medicine Graduate School of Medical Science Assistant professor
2021/04 - 2023/02 National Institute of Health Sciences Division of Organic Chemistry Visiting Researcher

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Awards (6)：

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