YOKOO HIDETOMO

ヨコオヒデトモ | YOKOO HIDETOMO

Affiliation and department：
Job title： Researcher
Research theme for competitive and other funds (4)：

2024 - 2027 様々なユビキチンリガーゼを巧みに利用した分解誘導剤の開発
2022 - 2025 ナノ粒子型タンパク質分解誘導剤の活用
2022 - 2024 Development of cell-penetrating E3 ligase ligand and its application to nanoparticle-based degraders.
2020 - 2022 Development of degrader targeting proteins regulated by ubiquitination

Papers (50)：

Michihiko Aoyama, Minoru Tada, Hidetomo Yokoo, Takahito Ito, Takashi Misawa, Yosuke Demizu, Akiko Ishii-Watabe. Linker and Conjugation Site Synergy in Antibody-Drug Conjugates: Impacts on Biological Activity. Bioconjugate chemistry. 2024. 35. 10. 1568-76
Kanako Horikoshi, Maho Miyamoto, Keisuke Tsuchiya, Hidetomo Yokoo, Yosuke Demizu. Dual-modified penetratin peptides: Enhancing nucleic acid delivery through stapling and endosomal escape domain. Bioorganic & medicinal chemistry. 2024. 111. 117871-117871
Hanqiao Xu, Nobumichi Ohoka, Takao Inoue, Hidetomo Yokoo, Yosuke Demizu. Photo-regulated PROTACs: A novel tool for temporal control of targeted protein degradation. Bioorganic & medicinal chemistry letters. 2024. 107. 129778-129778
Zhou Dongrui, Maho Miyamoto, Hidetomo Yokoo, Yosuke Demizu. Innovative peptide architectures: advancements in foldamers and stapled peptides for drug discovery. Expert opinion on drug discovery. 2024. 19. 6. 1-25
Hidetomo Yokoo, Genichiro Tsuji, Takao Inoue, Mikihiko Naito, Yosuke Demizu, Nobumichi Ohoka. Expansion of targeted degradation by Gilteritinib-Warheaded PROTACs to ALK fusion proteins. Bioorganic chemistry. 2024. 145. 107204-107204

ｍore...

MISC (12)：

堀越奏子, 堀越奏子, 横尾英知, 土屋圭輔, 出水庸介, 出水庸介. Development of amphipathic stapled peptides for efficient intercellular delivery of oligonucleotides. 日本薬学会年会要旨集(Web). 2024. 144th
古内志拓, 古内志拓, 横尾英知, 内藤幹彦, 井上貴雄, 大岡伸通, 出水庸介, 出水庸介, 出水庸介. Structure-activity relationship studies of novel E3 ligase ligands for use in the development of PROTAC. 日本薬学会年会要旨集(Web). 2024. 144th
高野玲奈, 高野玲奈, 横尾英知, 大岡伸通, 大金賢司, 井上貴雄, 出水庸介, 出水庸介. Development of PROTACs using UBR protein ligand. 日本薬学会年会要旨集(Web). 2024. 144th
辻厳一郎, 黒原崇, 横尾英知, 政田さやか, 内山奈穂子, 山本栄一, 出水庸介, 出水庸介, 出水庸介. A risk assessment of N-nitrosamine formation using in silico approach. 日本薬学会年会要旨集(Web). 2024. 144th
小出達夫, 横尾英知, 青山佳敬, 魚返祐太朗, 山本栄一, 出水庸介, 内山奈穂子. 高度分析技術を用いた医薬品共結晶原薬の構造解析手法に関する研究. 日本薬剤学会年会講演要旨集(CD-ROM). 2024. 39th

ｍore...

Education (3)：

2016 - 2019 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Track of Life Science and Technology
2014 - 2016 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Track of Medical and Dental Science and Technology
2010 - 2014 Saitama University Faculty of Science Department of Chemistry

Professional career (1)：

Work history (10)：

2023/04 - 現在 Innovation Center of NanoMedicine (iCONM), Kawasaki Institute of Industrial Promotion Visiting Scientist
2023/03 - 現在 National Institute of Health Sciences Division of Organic Chemistry Researcher
2023/03 - 現在 Kyoto Prefectural University of Medicine Graduate School of Medical Science
2022/04 - 2023/02 Kyoto Prefectural University of Medicine Graduate School of Medical Science Assistant professor
2021/04 - 2023/02 National Institute of Health Sciences Division of Organic Chemistry Visiting Researcher

Show all

Awards (6)：

Show all

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page