Shirafuji Toshihiko

Affiliation and department：
Job title：特命助教

Research field (1)： Neuropathology

Research keywords (2)： neurodegenerative disease , phosphorylation

Research theme for competitive and other funds (7)：

2021 - 2024 脊髄小脳変性症でのPKCリン酸化を介した神経保護機構の解明と新規治療法への応用
2018 - 2021 CSPaリン酸化による神経終末保護作用に着目した新規パーキンソン病治療法の開発
2016 - 2019 Screening and application of drugs that facilitate membrane trafficking in order to overcome ER stress-related diseases
2016 - 2019 Identification and application of novel chaperone mechanism using C-terminal deficient serotonin transporter as a sensor
2016 - 2018 Investigation of Parkinsonism by PKC pathway disruption and application for the new treatment for Parkinon's disease

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Papers (30)：

Takeshi Kaizuka, Taisei Hirouchi, Takeo Saneyoshi, Toshihiko Shirafuji, Mark O Collins, Seth G N Grant, Yasunori Hayashi, Toru Takumi. FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid-liquid phase separation. PLoS biology. 2024. 22. 3. e3002006
Kiyomichi Imamura, Ayaka Bota, Toshihiko Shirafuji, Toru Takumi. The blues and rhythm. Neuroscience research. 2023
Shirafuji T, Shimazaki H, Miyagi T, Ueyama T, Adachi N, Tanaka S, Hide I, Saito N, Sakai N. Spinocerebellar ataxia type 14 caused by a nonsense mutation in the PRKCG gene. Molecular and cellular neurosciences. 2019. 98. 46-53
Toshihiko Shirafuji, Takehiko Ueyama, Naoko Adachi, Ken-Ichi Yoshino, Yusuke Sotomaru, Junsuke Uwada, Azumi Kaneoka, Taro Ueda, Shigeru Tanaka, Izumi Hide, et al. The role of cysteine string protein α phosphorylation at serine 10 and 34 by protein kinase Cγ for presynaptic maintenance. Journal of Neuroscience. 2018. 38. 2. 278-290
Toshihiko Shirafuji, Takehiko Ueyama, Shigeru Tanaka, Izumi Hide, Naoaki Saito, Norio Sakai. Validation of Anti-CSP alpha, SNAP25, Tyrosine Hydroxylase, Ubiquitin, Cleaved Caspase 3, and pSer PKC Motif Antibodies for Utilization in Western Blotting. ACTA HISTOCHEMICA ET CYTOCHEMICA. 2017. 50. 6. 177-180

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MISC (28)：

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