2016 - 2019 Screening and application of drugs that facilitate membrane trafficking in order to overcome ER stress-related diseases
2016 - 2019 Identification and application of novel chaperone mechanism using C-terminal deficient serotonin transporter as a sensor
2016 - 2018 Investigation of Parkinsonism by PKC pathway disruption and application for the new treatment for Parkinon's disease
2013 - 2016 Determination of PKC substrate involved in neurodegenerative diseases and its application for drug design
2013 - 2016 Screening and development of drugs that can contribute to the treatment of intractable neuropsychiatric disease by regulating membrane trafficking and lysosomal degradation.
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Papers (29)：
Takeshi Kaizuka, Taisei Hirouchi, Takeo Saneyoshi, Toshihiko Shirafuji, Mark O Collins, Seth G N Grant, Yasunori Hayashi, Toru Takumi. FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid-liquid phase separation. PLoS biology. 2024. 22. 3. e3002006
Kiyomichi Imamura (co-firs, Ayaka Bota (co-firs, Toshihiko Shirafuji (co-firs, Toru Takumi. The blues and rhythm. Neuroscience research. 2023
Toshihiko Shirafuji, Takehiko Ueyama, Naoko Adachi, Ken-Ichi Yoshino, Yusuke Sotomaru, Junsuke Uwada, Azumi Kaneoka, Taro Ueda, Shigeru Tanaka, Izumi Hide, et al. The role of cysteine string protein α phosphorylation at serine 10 and 34 by protein kinase Cγ for presynaptic maintenance. Journal of Neuroscience. 2018. 38. 2. 278-290
