Shirafuji Toshihiko

Affiliation and department：

Research field (2)： Pharmacology , Neuropathology

Research keywords (5)：糖・脂質異常症 , 気分障害 , 時計遺伝子 , neurodegenerative disease , phosphorylation

Research theme for competitive and other funds (7)：

2021 - 2024 脊髄小脳変性症でのPKCリン酸化を介した神経保護機構の解明と新規治療法への応用
2018 - 2021 CSPaリン酸化による神経終末保護作用に着目した新規パーキンソン病治療法の開発
2016 - 2019 Screening and application of drugs that facilitate membrane trafficking in order to overcome ER stress-related diseases
2016 - 2019 Identification and application of novel chaperone mechanism using C-terminal deficient serotonin transporter as a sensor
2016 - 2018 Investigation of Parkinsonism by PKC pathway disruption and application for the new treatment for Parkinon's disease

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Papers (29)：

Takeshi Kaizuka, Taisei Hirouchi, Takeo Saneyoshi, Toshihiko Shirafuji, Mark O Collins, Seth G N Grant, Yasunori Hayashi, Toru Takumi. FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid-liquid phase separation. PLoS biology. 2024. 22. 3. e3002006
Kiyomichi Imamura, Ayaka Bota, Toshihiko Shirafuji, Toru Takumi. The blues and rhythm. Neuroscience research. 2023
Shirafuji T, Shimazaki H, Miyagi T, Ueyama T, Adachi N, Tanaka S, Hide I, Saito N, Sakai N. Spinocerebellar ataxia type 14 caused by a nonsense mutation in the PRKCG gene. Molecular and cellular neurosciences. 2019. 98. 46-53
Toshihiko Shirafuji, Takehiko Ueyama, Naoko Adachi, Ken-Ichi Yoshino, Yusuke Sotomaru, Junsuke Uwada, Azumi Kaneoka, Taro Ueda, Shigeru Tanaka, Izumi Hide, et al. The role of cysteine string protein α phosphorylation at serine 10 and 34 by protein kinase Cγ for presynaptic maintenance. Journal of Neuroscience. 2018. 38. 2. 278-290
Toshihiko Shirafuji, Takehiko Ueyama, Shigeru Tanaka, Izumi Hide, Naoaki Saito, Norio Sakai. Validation of Anti-CSP alpha, SNAP25, Tyrosine Hydroxylase, Ubiquitin, Cleaved Caspase 3, and pSer PKC Motif Antibodies for Utilization in Western Blotting. ACTA HISTOCHEMICA ET CYTOCHEMICA. 2017. 50. 6. 177-180

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MISC (29)：

白藤俊彦, 早田敦子, 早田敦子, 山脇洋輔, 今村聖路, 今村聖路, 竹田浩之, 東山繁樹, 内匠透, 内匠透, et al. PERIOD2(PER2)のリン酸化スイッチによる気分・概日リズムの制御機構の解明. 日本薬理学雑誌. 2023. 158. Supplement
白藤俊彦, 上山健彦, 足立直子, 齋藤尚亮. Cysteine String Protein alpha(CSPα)Ser34特異的リン酸化抗体の作製と機能解析. 日本組織細胞化学会総会・学術集会講演プログラム・予稿集. 2019. 60回. 85-85
田中茂, 嶋田直人, 宮城達博, 白榊紘子, 秀和泉, 白藤俊彦, 酒井規雄. 海馬神経細胞において内在性に発現するGPR3が神経極性形成に与える影響. 生命科学系学会合同年次大会. 2017. 2017年度. [2P-1153]
宇野珠世, 田中茂, 宮城達博, 秀和泉, 白藤俊彦, 酒井規雄, 入舩正浩. cAMPによるα3α5型ニコチン受容体機能の調整. 広島大学歯学雑誌. 2016. 48. 1. 84-84
白藤俊彦, 上山健彦, 吉野健一, 足立直子, 高橋英之, 平松直樹, 吾郷由希夫, 松田敏夫, 戸田達史, 酒井規雄, et al. PKCγKOパーキンソン症候群モデル βPIXリン酸化のドパミン遊離での役割. 臨床神経学. 2014. 54. Suppl. S242-S242

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