Rchr
J-GLOBAL ID：202101001814671410
Update date: May. 01, 2024
Shimizu Naoto
シミズ ナオト | Shimizu Naoto
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Affiliation and department：
National Institute of Health Sciences Division of Cell-based Therapeutic Products
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Detailed information
Research field (4)：
Molecular biology
, Cell biology
, Environmental effects of chemicals
, Environmental effects of radiation
Research keywords (5)：
TK6細胞
, DNA損傷
, DNA修復
, 放射線・抗がん剤
, がん
Research theme for competitive and other funds (2)：
2022 - 2025 放射線が誘発するDNA二本鎖切断の修復中間体解消機構の解明
2022 - 2024 MRE11の新機能に着目したMRNの動的構造解析
Papers (10)：
Ryosuke Morozumi, Naoto Shimizu, Kouhei Tamura, Makoto Nakamura, Atsushi Suzuki, Hiroko Ishiniwa, Hiroshi Ide, Masataka Tsuda. Changes in repair pathways of radiation-induced DNA double-strand breaks at the midblastula transition in
Xenopus
embryo. Journal of Radiation Research. 2024
Tasnim Ahmad, Ryotaro Kawasumi, Tomoya Taniguchi, Takuya Abe, Kazuhiro Terada, Masataka Tsuda, Naoto Shimizu, Toshiki Tsurimoto, Shunichi Takeda, Kouji Hirota. The proofreading exonuclease of leading-strand DNA polymerase epsilon prevents replication fork collapse at broken template strands. Nucleic Acids Research. 2023. 51. 22. 12288-12302
Naoto Shimizu, Yusaku Hamada, Ryosuke Morozumi, Junpei Yamamoto, Shigenori Iwai, Kei-ichi Sugiyama, Hiroshi Ide, Masataka Tsuda. Repair of topoisomerase 1-induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding. Journal of Biological Chemistry. 2023. 299. 8. 104988-104988
Rifat Ara Najnin, Md Rasel Al Mahmud, Md Maminur Rahman, Shunichi Takeda, Hiroyuki Sasanuma, Hisashi Tanaka, Yasuhiro Murakawa, Naoto Shimizu, Salma Akter, Masatoshi Takagi, et al. ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen. Cell Reports. 2023. 42. 1. 111909-111909
Kouji Hirota, Masato Ooka, Naoto Shimizu, Kousei Yamada, Masataka Tsuda, Mahmoud Abdelghany Ibrahim, Shintaro Yamada, Hiroyuki Sasanuma, Mitsuko Masutani, Shunichi Takeda. XRCC1 counteracts PARP poisons, Olaparib and Talazoparib, and a clinical alkylating agent, Temozolomide, by promoting the removal of trapped PARP1 from broken DNA. Genes to Cells. 2022. 27. 5. 331-344
ｍore...
MISC (3)：
清水直登, 津田雅貴. 新規DNA修復機構に着目した新たながん治療法. 月刊細胞. 2024. 56. 2. 36-38
清水直登. 放射線が誘発するDNA二本鎖切断の修復中間体解消機構の解明. 放影協ニュース. 2023. 4. 114. 15-16
津田雅貴, 清水直登. トポイソメラーゼ阻害剤が引き起こすDNA損傷の修復機構. 月刊細胞. 2021. 53. 12. 792-794
Lectures and oral presentations (15)：
相同組換え中間体解消における動的変化の可視化
(第46回日本分子生物学会年会 2023)
相同組換え中間体解消における動的変化を可視化する技術の開発
(日本環境変異原ゲノム学会第52回大会 2023)
チロシル-DNAホスホジエステラーゼ2(TDP2)による新たな DNA 修復機構の解明
(日本環境変異原ゲノム学会第52回大会 2023)
相同組換え中間体解消における動的変化を可視化する技術の開発
(日本放射線影響学会第66回大会 2023)
DNAにトラップされたタンパク質が引き起こすゲノム毒性とその関連疾患
(第50回日本毒性学会学術年会 2023)
ｍore...
Education (3)：
2017 - 2021 京都大学大学院 医学研究科 医学専攻
2015 - 2017 University of Tsukuba Graduate School of Comprehensive Human Sciences
2011 - 2015 Tokyo Metropolitan University
Professional career (1)：
Ph.D. (Medicine) (Kyoto University)
Work history (2)：
2024/04 - 現在 National Institute of Health Sciences
2021/04 - 2024/03 Hiroshima University
Association Membership(s) (2)：
日本環境変異原ゲノム学会
, 日本放射線影響学会
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