Zhang Ming-Rong

チョウメイエイ | Zhang Ming-Rong

Affiliation and department：
Job title： Director

Research field (3)： Tumor diagnostics and therapeutics , Pharmaceuticals - chemistry and drug development , Radiology

Research keywords (6)： Radiochemistry , Radiopharmaceutical Chemistry , Molecular Imaging , Theranostics , Targeted Radionuclide Therapy (TRT) , PET/SPECT

Research theme for competitive and other funds (22)：

2023 - 2028 Comprehensive basic research for the development of therapies targeting senescent cells and their clinical applications
2024 - 2027 環状ヌクレオチドホスホジエステラーゼ7を標的とするPETプローブの開発
2023 - 2027 Development of New Positron Emission Tomography Probes for Imaging PDE7
2022 - 2025 Development of new radiotherapeutic drugs against metabolism of refractory bile duct cancer
2021 - 2025 Stapled peptide-based radiotheranostics for intracellular protein-protein interactions targeted cancer imaging and therapy

2021 - 2024 mGluR1を標的とするα線Radio-theranosticsシステムの確立

2020 - 2024 Development of PET probes for gama 8-dependent transmembrane AMPA receptor regulatory protein

2019 - 2023 Development of positron emission tomography tracers evaluating the safety and oncotherapy effect for photodynamic therapy

2019 - 2022 Development of imaging method for early pancreatic cancer by high-resolution PET using radiolabeled antibody

2017 - 2021 Development of novel PET probes for imaging of metabotropic glutamate receptor subtype 2

2017 - 2020 Visualization of monoacylglycerol lipase in ischemia rat brain using [11C]SAR127303 and development of new PET probes.

2014 - 2018 Development of imaging agents for feeding function as a diagnostic tool and evaluation of drug therapy for obesity

2013 - 2017 Development of radioprobes by targeted metabotropic glutamate receptor 1 in tumor

2012 - 2016 Molecular imaging of metablotropic glutamate receptor type 1 – a first-in-human study

2012 - 2015 Development of peptide-based PET probe targeting integrin alpha5beta1

2011 - 2013 Evaluation of 14C(11C)-Benzyl acetate as a potential probe for the measurement of glial metabolism.

2011 - 2013 Development of PET probes to aim early diagnosis and evaluation of treatment for eating disorders

2010 - 2012 Development of Novel PET Probes for Metabotropic Glutamate Receptor Subtype 1 (mGluR1)

2009 - 2010 Development of molecular probes for imidazoline receptor subtypes exhaustively

2007 - 2009 Study on functional roles of PBR (TSPO) in glia and myocardium

2007 - 2008 Development of PET, SPECT and Fluorescence Probes for Imaging of Peripheral Benzodiazepine Receptors

2007 - 2008 超高比放射能標識リガンドによる生体超微量現象の解明

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Papers (466)：

Rin Yanai, Tomoki T Mitani, Etsuo A Susaki, Takeharu Minamihisamatsu, Masafumi Shimojo, Yuri Saito, Hiroshi Mizuma, Nobuhiro Nitta, Daita Kaneda, Yoshio Hashizume, et al. A novel tauopathy model mimicking molecular and spatial aspects of human tau pathology. Brain Communications. 2024. 6. 5
Yiding Zhang, Lin Xie, Masayuki Fujinaga, Yusuke Kurihara, Masanao Ogawa, Katsushi Kumata, Wakana Mori, Tomomi Kokufuta, Nobuki Nengaki, Hidekatsu Wakizaka, et al. L-[5-11C]Glutamine PET imaging noninvasively tracks dynamic responses of glutaminolysis in non-alcoholic steatohepatitis. Acta Pharmaceutica Sinica B. 2024
Siqi Zhang, Xiaohui Ma, Jiang Wu, Jieting Shen, Yuntao Shi, Xingkai Wang, Lin Xie, Xiaona Sun, Yuxuan Wu, Hao Tian, et al. Enhanced radiotheranostic targeting of integrin α5β1 with PEGylation-enabled peptide multidisplay platform (PEGibody): A strategy for prolonged tumor retention with fast blood clearance. Acta Pharmaceutica Sinica B. 2024
Mitsuhiro Shinada, Masashi Takahashi, Chika Igarashi, Hiroki Matsumoto, Fukiko Hihara, Tomoko Tachibana, Masakazu Oikawa, Hisashi Suzuki, Ming-Rong Zhang, Tatsuya Higashi, et al. 64Cu2+ Complexes of Tripodal Amine Ligands' In Vivo Tumor and Liver Uptakes and Intracellular Cu Distribution in the Extrahepatic Bile Duct Carcinoma Cell Line TFK-1: A Basic Comparative Study. Pharmaceuticals (Basel, Switzerland). 2024. 17. 7
Zhongshan He, Wei Chen, Kuan Hu, Yaoyao Luo, Wanqin Zeng, Xi He, Tingting Li, Jiang Ouyang, Yongjiang Li, Lin Xie, et al. Resolvin D1 delivery to lesional macrophages using antioxidative black phosphorus nanosheets for atherosclerosis treatment. Nature Nanotechnology. 2024

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MISC (106)：

謝琳, 破入正行, 張一鼎, 藤永雅之, 峯岸克行, 大久保崇之, 永津弘太郎, 下川卓志, 足助一真, 張明栄. mGluR1陽性ヒト癌に対する211At-AITMによる標的アイソトープ治療の検証. 核医学(Web). 2023. 60. Supplement
吉井幸恵, 檜原扶紀子, 五十嵐千佳, 張明栄, 大島聡人, 佐藤秀光, 成田善孝, 栗原宏明, 山本哲哉, 東達也, et al. 低酸素標的放射性薬剤⁶⁴Cu-ATSMを用いた高悪性度神経膠腫に対する局所治療. 核医学(Web). 2023. 60. Supplement
山崎友照, 藤永雅之, 大久保崇之, 大久保崇之, 下條雅文, 小野麻衣子, 永井裕司, 小川政直, 念垣信樹, 小川政直, et al. 新規レポーター遺伝子イメージング剤[¹⁸F]FE-TMP-d4の小動物を用いた有効性評価. 核医学(Web). 2023. 60. Supplement
矢内凛, 南久松丈晴, 下條雅文, 洲崎悦生, 三谷智樹, 上田泰己, 張明栄, 佐原成彦, 樋口真人. 透明化とPETを用いた新規タウオパチーモデルマウスの全脳3Dイメージング. Dementia Japan. 2023. 37. 4
河村和紀, 森若菜, 栗原雄祐, 小川政直, 塚越海渡, 大久保崇之, 念垣信樹, 藤永雅之, 橋本裕輝, 張明栄, et al. 臨床利用へ向けた簡易的1ポット[¹⁸F]FMeNER-D₂製造法の確立. 核医学(Web). 2023. 60. Supplement

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Patents (26)：

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Work history (5)：

2016/04 - 現在 National Institutes for Quantum and Radiological Science and Technology Department of Advanced Nuclear Medicine Sciences Director
2012/04 - 2016/03 National Institute of Radiological Sciences
2007/10 - 2012/03 放射線医学総合研究所分子認識研究グループ標識技術チームチームリーダー
2000/03 - 2007/09 放射線医学総合研究所研究員
1998/04 - 2000/03 科学技術振興事業団博士研究員

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