Higashi Kenjirou

ヒガシケンジロウ | Higashi Kenjirou

Affiliation and department：
Homepage URL (1)： https://www.p.chiba-u.jp/lab/seizai/higashi.html

Research field (1)： Pharmaceuticals - analytical and physicochemistry

Research keywords (7)： stability , solubility , solid state NMR , nanoparticle , solid dispersion , cyclodextrin , Molecular Pharmaceutics

Research theme for competitive and other funds (16)：

2022 - 2026 Study on the origin of sustained drug releasability of polymeric nanomicelles based on clarifying the interaction potential surface
2022 - 2025 Development of drug-rich phase-coexisting lipid nanoparticle formulations based on elucidation of molecular mechanism of liquid-liquid phase separation phenomenon of drugs
2021 - 2024 Structural evaluation of solid-liquid interface of drug nanoamorphous by suspended-state NMR
2020 - 2023 Drug dissolution mechanism based on evaluation of polymer structure, mobility, and intermolecular interaction
2018 - 2021 Design of drug amorphous nanosuspension to achieve a pharmaceutical formulation of poorly water-soluble drug

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Papers (177)：

Etsushi Yoshikawa, Keisuke Ueda, Rei Hakata, Kenjirou Higashi, Kunikazu Moribe. Quantitative Investigation of Intestinal Drug Absorption Enhancement by Drug-Rich Nanodroplets Generated via Liquid-Liquid Phase Separation. Molecular Pharmaceutics. 2024
Sudeshna Kundu, Kenjirou Higashi, Makoto Takamizawa, Keisuke Ueda, Waree Limwikrant, Keiji Yamamoto, Kunikazu Moribe. Controlled Sublimation Rate of Guest Drug from Polymorphic Forms of a Cyclodextrin-Based Polypseudorotaxane Complex and Its Correlation with Molecular Dynamics as Probed by Solid-State NMR. Molecular Pharmaceutics. 2024
Yushi Sunazuka, Keisuke Ueda, Kenjirou Higashi, Koichi Wada, Kunikazu Moribe. Mechanistic Analysis of Temperature-Dependent Curcumin Release from Poly(lactic-co-glycolic acid)/Poly(lactic acid) Polymer Nanoparticles. Molecular Pharmaceutics. 2024
Jessica Anindita, Hiroki Tanaka, Takuma Yamakawa, Yuka Sato, Chika Matsumoto, Kota Ishizaki, Taiji Oyama, Satoko Suzuki, Keisuke Ueda, Kenjirou Higashi, et al. The Effect of Cholesterol Content on the Adjuvant Activity of Nucleic-Acid-Free Lipid Nanoparticles. Pharmaceutics. 2024. 16. 2
Kazunori Kadota, Tero Kämäräinen, Fumie Sakuma, Keisuke Ueda, Kenjirou Higashi, Kunikazu Moribe, Hiromasa Uchiyama, Katsuhiko Minoura, Yuichi Tozuka. Unveiling the flavone-solubilizing effects of α-glucosyl rutin and hesperidin: probing structural differences through NMR and SAXS analyses. Food & function. 2023

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MISC (318)：

真野結奈, 金沢貴憲, 金沢貴憲, 芹澤未来, 東顕二郎, 照喜名孝之, 近藤啓. マイクロ流体デバイス法により調製したDOPCナノ粒子の形態に及ぼすコレステロール含量・PEG修飾の影響. 日本DDS学会学術集会プログラム予稿集. 2023. 39th
佐々木香純, 奥脇弘次, 古石誉之, 東顕二郎, 福澤薫, 福澤薫, 米持悦生. Characterization of lipid nanoparticle-nucleic acid complexes by experimental methods and molecular simulations. 日本薬学会年会要旨集(Web). 2023. 143rd
東顕二郎, 植田圭祐, 森部久仁一. Solubility improvement of poorly water-soluble drugs by additives~basic theory and introduction of recent study~. Pharm Tech Japan. 2023. 39. 4
伊藤博光, 伊藤博光, 神田真由美, 真壁宗義, 河合幸紀, 植田圭祐, 東顕二郎, 森部久仁一. Rheological analysis of thickening behavior of drug nanosuspensions. 日本薬剤学会年会講演要旨集(CD-ROM). 2023. 38th
植田圭祐, 菅澤祐昭, 東顕二郎, 森部久仁一. In-situ Characterization of Nano-Formulations by Atomic Force Microscopy (AFM). 製剤機械技術学会誌. 2023. 32. 3

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Patents (7)：

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Books (10)：

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Education (3)：

2011 - Chiba University Graduate School of Pharmaceutical Sciences
2004 - 2006 Chiba University Graduate School of Medical and Pharmaceutical Sciences
2000 - 2004 Chiba University Faculty of Pharmaceutical Sciences

Professional career (1)：

Work history (5)：

2018/01 - 現在 Chiba University Graduate School of Pharmaceutical Sciences Associate Professor
2014/10 - 2017/12 Chiba University Graduate School of Pharmaceutical Sciences Associate Professor, Tenure track
2007/04 - 2014/09 Chiba University Graduate School of Pharmaceutical Sciences Assistant Professor
2012/09 - 2013/09 The University of Michigan Biophysics Visiting researcher
2006/04 - 2007/03 田辺製薬株式会社製剤研究部研究員

Awards (6)：

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