Oshima Motohiko

オオシマモトヒコ | Oshima Motohiko

Affiliation and department：
Job title： Assistant Professor

Research field (2)： Hematology and oncology , Molecular biology

Research theme for competitive and other funds (8)：

2021 - 2024 Molecular basis of MDS pathogenesis and construction of novel MDS prognostic model
2019 - 2024 Deciphering of the epigenetic machinery that determines the hallmarks of hematopoietic stem cell aging
2020 - 2023 Study for the regulation of exit from quiescent self-renewing programs in human hematopoietic stem cells by chromatin looping factor, CTCF
2018 - 2021 Epigenetic changes in hematopoietic system during aging and molecular basis of hematopoietic tumor
2017 - 2019 Role of the polycomb-group protein Pcgf1 in hematopoietic

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Papers (106)：

Satoshi Kaito, Kazumasa Aoyama, Motohiko Oshima, Akiho Tsuchiya, Makiko Miyota, Masayuki Yamashita, Shuhei Koide, Yaeko Nakajima-Takagi, Hiroko Kozuka-Hata, Masaaki Oyama, et al. Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization. Nature Communications. 2024. 15. 1
Sudip Kumar Paul, Motohiko Oshima, Ashwini Patil, Masamitsu Sone, Hisaya Kato, Yoshiro Maezawa, Hiyori Kaneko, Masaki Fukuyo, Bahityar Rahmutulla, Yasuo Ouchi, et al. Retrotransposons in Werner syndrome-derived macrophages trigger type I interferon-dependent inflammation in an atherosclerosis model. Nature communications. 2024. 15. 1. 4772-4772
海渡智史, 青山和正, 大島基彦, 中島やえ子, 小出周平, 山下真幸, 上野将也, 平尾敦, 通山薫, 岩間厚志. TOPORSの機能抑制はDNMT1の安定化を介してDNAメチル化阻害剤の効果を増強する. 日本血液学会学術集会. 2023. 85回. 286-286
大島基彦, 高山直也, 中島やえ子, 小出周平, 原田浩徳, 原田結花, Ding Ye, 明星智洋, 岩間厚志. 幹細胞分画を用いたクロマチン特性解析による骨髄異形成症候群の病態解明. 日本血液学会学術集会. 2023. 85回. 398-398
海渡智史, 青山和正, 大島基彦, 中島やえ子, 小出周平, 山下真幸, 上野将也, 平尾敦, 通山薫, 岩間厚志. TOPORSの機能抑制はDNMT1の安定化を介してDNAメチル化阻害剤の効果を増強する. 日本血液学会学術集会. 2023. 85回. 530-530

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MISC (46)：

関根亜由美, 中島やえ子, 大島基彦, 小出周平, 佐々木篤志, 新子寿美奈, 伊狩潤, 坂尾誠一郎, 田邉信宏, 巽浩一郎, et al. Runx1-regulated endothelial hematopoietic transition contributes to pulmonary hypertension. 日本呼吸器学会誌(Web). 2023. 12
柴宮明日香, 三村尚也, 長井友莉恵, 小出周平, リズク・オラ, 大島基彦, 栢森健介, 一色佑介, 日野裕太郎, 大島渚, et al. ヒト骨髄腫の遺伝子変異を持つ形質細胞腫瘍モデルマウスを用いた疲弊T細胞の解析(Functional and transcriptional analyses of exhausted T cells in a mouse model of plasma cell neoplasms with human MM mutations). International Journal of Myeloma. 2022. 12. 3. 134-134
青山和正, 篠田大輔, 鈴木瑛美, 中島やえ子, 大島基彦, 小出周平, Ola Rizq, 太良史郎, 指田吾郎, 岩間厚志. PRC2の機能低下は、Cdkn2aの脱抑制を介して骨髄異形成症候群におけるp53依存性赤血球産生異常を誘発する. 日本生化学会大会プログラム・講演要旨集. 2021. 94回. [P-740]
一色佑介, 大島基彦, 三村尚也, 栢森健介, 長井友莉恵, 関真秀, 中島やえ子, 武藤朋也, 塚本祥吉, 竹田勇輔, et al. Identification of transcriptional features & surface markers of plasma cell clones in POEMS syndrome(和訳中). 日本血液学会学術集会. 2021. 83回. PL-5
大島基彦, 高山直也, 中島やえ子, 小出周平, 原田浩徳, 原田結花, Ding Ye, 明星智洋, 岩間厚志. MDS幹・前駆細胞の分子病態解析(Molecular pathogenesis in MDS stem and progenitor cells). 日本血液学会学術集会. 2021. 83回. OS1-1

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Lectures and oral presentations (9)：

MDS病態の分子基盤の解明と新規予後予測システムの構築
(第25回造血器腫瘍研究会 2021)
Profiling of chromatin accessibility of aged hematopoietic stem cells
(2020)
Epigenetic changes in hematopoietic stem and progenitor cells during aging
(2020)
Activation of Keap1-Nrf2 pathway in HSCs during aging
(2019)
Epigenetic hallmarks of aging hematopoietic stem cells
(2018)

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Professional career (1)：

Ph.D. (Medicine) (University of Tsukuba)

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