Mukohyama Junko

ムコウヤマジュンコ | Mukohyama Junko

Affiliation and department：
Job title： Lecturer

Research field (2)： Digestive surgery , Molecular biology

Research keywords (5)： CDX2 , microRNA , Cancer Stem Cell , 細胞系譜解析 , Colorectal Cancer

Research theme for competitive and other funds (10)：

2021 - 2024 Development and application of an early detection method for postoperative recurrence of colorectal cancer using tears
2020 - 2023 内分泌細胞由来大腸癌に対する新規治療法の探索
2020 - 2023 Elucidation of the mechanism of maturation of tertiary lymph structure in gastric cancer tumor immune microenvironment and identification of the therapeutic antibodies
2021 - Dissection of the cell composition and find selective pharmacological target of CDX2-negative colon cancer
2017 - 2020 The regulation of colon cancer stem cell by QKI5

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Papers (30)：

Junko Mukohyama, Kyosuke Agawa, Kimihiro Yamashita, Takeru Matsuda, Masahiro Shinoda, Osamu Itano, Yoshihiro Kakeji. CDX2 Is a Prognostic Biomarker for Unresectable Metastatic Colorectal Cancer. Anticancer research. 2023. 43. 8. 3763-3767
下野洋平, 久森重夫, 向山順子, 林孝典, 前田真男, 磯部大地, 浅井直也, 掛地吉弘. 正常最終分化細胞の解析によるがん幹細胞抑制性マイクロRNAの同定(Analyses of terminally differentiated normal cells guide the identification of cancer stem cell-suppressor microRNAs). 日本癌学会総会記事. 2022. 81回. MS2-2
Shigeo Hisamori, Junko Mukohyama, Sanjay Koul, Takanori Hayashi, Michael Evan Rothenberg, Masao Maeda, Taichi Isobe, Luis Enrique Valencia Salazar, Xin Qian, Darius Michael Johnston, et al. Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells. Journal of gastroenterology. 2022. 57. 6. 407-422
Steven De Munck, Mathias Provost, Michiko Kurikawa, Ikuko Omori, Junko Mukohyama, Jan Felix, Yehudi Bloch, Omar Abdel-Wahab, J Fernando Bazan, Akihide Yoshimi, et al. Structural basis of cytokine-mediated activation of ALK family receptors. Nature. 2021. 600. 7887. 143-147
Kyosuke Agawa, Kimihiro Yamashita, Akio Nakagawa, Kouta Yamada, Akihiro Watanabe, Junko Mukohyama, Masafumi Saito, Mitsugu Fujita, Gosuke Takiguchi, Naoki Urakawa, et al. Simple Cancer Stem Cell Markers Predict Neoadjuvant Chemotherapy Resistance of Esophageal Squamous Cell Carcinoma. Anticancer research. 2021. 41. 8. 4117-4126

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MISC (62)：

Junko Mukohyama, Masahiro Shinoda, Osamu Itano, Yoshihiro Kakeji, Yohei Shimono. Identification of the epigenetic mechanism for colorectal cancer stem cell regulation through the comprehensive microRNA expression profiling of human colorectal cancer tissues. ASCO Breakthrough. 2023
向山順子, 篠田昌宏, 吉見昭秀, 板野理, 掛地吉弘, Piero Dalerba, 下野洋平. 手術検体を活用した癌関連マイクロRNA-221による大腸癌幹細胞制御機構の解析. 第78回日本消化器外科学会総会. 2023. P142-P147
向山順子, 篠田昌宏, 掛地吉弘, 板野理. 外科医で女性で子持ちで研究者は四重苦? Physician scientistとして「外科的治療だけでは難しい癌」を外科医が研究する意義. 日本外科学会定期学術集会抄録集. 2023. 123回. HFT-1
篠田昌宏, 竹部兼輔, 坂本敏哉, 榛澤侑介, 向山順子, 加藤文彦, 加藤亜裕, 似鳥修弘, 星本相淳, 羽鳥隆, et al. 当院における外科系診療科を中心とした救急医療体制充実の試みと成果. 日本外科学会定期学術集会抄録集. 2023. 123回. DP-2
竹部兼輔, 篠田昌宏, 坂本敏哉, 佐藤豊, 向山順子, 加藤文彦, 加藤亜裕, 似鳥修弘, 皆川卓也, 星本相淳, et al. 当センターにおける85歳以上の高齢者に対する緊急腹部手術の後方視的検討. 日本外科学会定期学術集会抄録集. 2023. 123回. DP-4

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Books (1)：

手術室デバイスカタログ外科医視点による性能比較・解説
金原出版 2022 ISBN:4307204328

Lectures and oral presentations (63)：

Dissection of transcriptional heterogeneity and optimized therapy for colorectal cancer
(The 110th General Meeting of the Japanese Society of Gastroenterology 2024)
三刀流ママ外科医、Surgeon-scientistとして「外科的治療だけでは治癒が難しい癌」を研究する
(第123回日本外科学会定期学術集会 2024)
CDX2低発現大腸癌の臨床学的予後と腫瘍生物学的特性についての解析
(第34回日本消化器癌発生学会総会 2023)
女性外科医がAcademic surgeon として多方面で活躍するために働き方改革を契機としたインセンティブ導入の提言
(第85回日本臨床外科学会総会 2023)
手術検体を活用した癌マイクロRNA-221による大腸癌幹細胞制御機構の解析
(第78回日本消化器外科学会総会 2023)

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Education (2)：

2013 - 2017 Kobe University Graduate School of Medicine Department of Gastrointestinal Surgery
2003 - 2009 Kochi University Medical School Medical Course

Work history (6)：

2021 - 現在 International University of Health and Welfare MITA Hospital Department of Hepato-Biliary-Pancreatic and Gastrointestinal Surgery Lecturer
2013 - 現在 Kobe University Graduate School of Medicine Division of Gastrointestinal Surgery
2020 - 2021 Japan Society for the Promotion of Science Overseas Special Research Fellow
2017 - 2021 Columbia university Department of Pathology and Cell Biology Postdoctoral scientist
2011 - 2013 Steel Memorial Hirohata Hospital Department of Surgery

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Awards (12)：

2023 - 日本外科学会若手外科医のための臨床研究助成右側発症難治性大腸癌に対する最適化治療の確立
2023 - Japan Medical Women's Association Hiroko Yamamoto Award (International Award)
2021 - International Colorectal Research Summit Excellence Oral Presentation Award miR-221 Targets QKI5 and Enhances Functional Behaviors of Cancer Stem Cells in Human Colon Cancers
2021 - Japanese Cancer Association Young Investigator Award Comprehensive microRNA expression profiling utilizing clinical specimens of colon cancer and elucidating novel molecular mechanism regulating cancer stem cell functions.
2020 - Japanese Cancer Association Excellent Award for Women Scientists in Cancer Research CDX2 as a Prognostic and Predictive Biomarker in Colon Cancer.

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