Rchr
J-GLOBAL ID:202201013024733713
Update date: Nov. 17, 2024
Mukohyama Junko
ムコウヤマ ジュンコ | Mukohyama Junko
Affiliation and department:
Job title:
Assistant professor
Research field (2):
Digestive surgery
, Molecular biology
Research keywords (5):
CDX2
, microRNA
, Cancer Stem Cell
, 細胞系譜解析
, Colorectal Cancer
Research theme for competitive and other funds (11):
- 2023 - 2026 ヒト肝癌移植Il2rg-KOブタを用いた酸化チタンナノ粒子超音波併用肝動注療法
- 2021 - 2024 Development and application of an early detection method for postoperative recurrence of colorectal cancer using tears
- 2020 - 2023 内分泌細胞由来大腸癌に対する新規治療法の探索
- 2020 - 2023 Elucidation of the mechanism of maturation of tertiary lymph structure in gastric cancer tumor immune microenvironment and identification of the therapeutic antibodies
- 2021 - Dissection of the cell composition and find selective pharmacological target of CDX2-negative colon cancer
- 2017 - 2020 The regulation of colon cancer stem cell by QKI5
- 2019 - 女性優位に発症する高再発性大腸癌の細胞系譜解析
- 2016 - 2018 Molecular Analysis of CDX2 low colorectal cancer
- 2018 - Elucidating the molecular identity of human EpCAM+/CDX2neg colon cancer cells.
- 2018 - Analysis of early metastasis formation of colorectal cancer by using single cell RNA-sequence
- 2015 - 2017 Molecular basis for the establishment of early metastatic lesion through cell adaptation
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Papers (32):
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JUNKO MUKOHYAMA, MINORI KOIZUMI, KIMIHIRO YAMASHITA, AKIHIDE YOSHIMI, DAI SHIDA, YOSHIHIRO KAKEJI. Knockdown of CDX2 Induces microRNA-221 Up-regulation in Human Colon Cancer Cells. Anticancer Research. 2024. 44. 8. 3553-3556
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板野 理, 星本 相淳, 大山 隆史, 鶴田 雅士, 平野 佑樹, 石田 隆, 皆川 卓也, 島田 理子, 田村 卓也, 篠田 昌宏, et al. 「手術室デバイスカタログ」おける手術医療機器教育. 日本消化器外科学会雑誌. 2023. 56. Suppl.2. 572-572
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Junko Mukohyama, Kyosuke Agawa, Kimihiro Yamashita, Takeru Matsuda, Masahiro Shinoda, Osamu Itano, Yoshihiro Kakeji. CDX2 Is a Prognostic Biomarker for Unresectable Metastatic Colorectal Cancer. Anticancer research. 2023. 43. 8. 3763-3767
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下野 洋平, 久森 重夫, 向山 順子, 林 孝典, 前田 真男, 磯部 大地, 浅井 直也, 掛地 吉弘. 正常最終分化細胞の解析によるがん幹細胞抑制性マイクロRNAの同定(Analyses of terminally differentiated normal cells guide the identification of cancer stem cell-suppressor microRNAs). 日本癌学会総会記事. 2022. 81回. MS2-2
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Shigeo Hisamori, Junko Mukohyama, Sanjay Koul, Takanori Hayashi, Michael Evan Rothenberg, Masao Maeda, Taichi Isobe, Luis Enrique Valencia Salazar, Xin Qian, Darius Michael Johnston, et al. Upregulation of BMI1-suppressor miRNAs (miR-200c, miR-203) during terminal differentiation of colon epithelial cells. Journal of gastroenterology. 2022. 57. 6. 407-422
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MISC (85):
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向山 順子, 篠田 昌宏, 掛地 吉弘, 板野 理. 外科医が基礎研究を行う意義-PhysiologyとOncologyの観点から- 三刀流ママ外科医,Surgeon-scientistとして「外科的治療だけでは治癒が難しい癌」を研究する. 日本外科学会定期学術集会抄録集. 2024. 124回. SY-6
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島田 理子, 石田 隆, 大塚 哲哉, 田村 卓也, 皆川 卓也, 平野 佑樹, 鶴田 雅士, 大山 隆史, 星本 相淳, 藤原 弘毅, et al. 医学生および外科医からみた外科医に関するイメージ調査比較結果からみた外科臨床実習のありかたについての検討. 日本外科学会定期学術集会抄録集. 2024. 124回. SF-3
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藤原 弘毅, 篠田 昌宏, 与儀 憲和, 坂本 敏哉, 向山 順子, 加藤 文彦, 加藤 亜裕, 皆川 卓也, 星本 相淳, 首村 智久, et al. 当センターにおける85歳以上の高齢者腹部緊急手術の成績. 日本外科学会定期学術集会抄録集. 2024. 124回. PS-8
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与儀 憲和, 坂本 敏哉, 加藤 文彦, 加藤 亜裕, 向山 順子, 藤原 弘毅, 羽鳥 隆, 篠田 昌宏, 宮崎 勝, 相田 真介, et al. 高度局所進行膵癌に対し腹腔動脈合併膵体尾部切除術+左腎摘出術+十二指腸部分切除術を施行した1例. 千葉医学雑誌. 2024. 100. 2. 28-28
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与儀 憲和, 坂本 敏哉, 加藤 文彦, 加藤 亜裕, 向山 順子, 藤原 弘毅, 羽鳥 隆, 篠田 昌宏, 小無田 美菜, 相田 真介, et al. 高度局所進行膵癌に対し腹腔動脈+左腎+十二指腸合併膵体尾部切除を施行した一例. 日本臨床外科学会雑誌. 2024. 85. 3. 447-448
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Books (1):
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手術室デバイスカタログ 外科医視点による性能比較・解説
金原出版 2022 ISBN:4307204328
Lectures and oral presentations (63):
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Dissection of transcriptional heterogeneity and optimized therapy for colorectal cancer
(The 110th General Meeting of the Japanese Society of Gastroenterology 2024)
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三刀流ママ外科医、Surgeon-scientistとして「外科的治療だけでは治癒が難しい癌」を研究する
(第123回日本外科学会定期学術集会 2024)
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CDX2低発現大腸癌の臨床学的予後と腫瘍生物学的特性についての解析
(第34回日本消化器癌発生学会総会 2023)
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女性外科医がAcademic surgeon として多方面で活躍するために 働き方改革を契機としたインセンティブ導入の提言
(第85回日本臨床外科学会総会 2023)
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手術検体を活用した癌マイクロRNA-221による大腸癌幹細胞制御機構の解析
(第78回日本消化器外科学会総会 2023)
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Education (2):
- 2013 - 2017 Kobe University Graduate School of Medicine Department of Gastrointestinal Surgery
- 2003 - 2009 Kochi University Medical School Medical Course
Work history (7):
- 2024/05 - 現在 The Institute of Medical Science, The University of Tokyo, Department of Surgery Assistant Professor
- 2013 - 現在 Kobe University Graduate School of Medicine Division of Gastrointestinal Surgery
- 2021 - 2024/04 International University of Health and Welfare MITA Hospital Department of Hepato-Biliary-Pancreatic and Gastrointestinal Surgery Lecturer
- 2020 - 2021 Japan Society for the Promotion of Science Overseas Special Research Fellow
- 2017 - 2021 Columbia university Department of Pathology and Cell Biology Postdoctoral scientist
- 2011 - 2013 Steel Memorial Hirohata Hospital Department of Surgery
- 2009 - 2011 Himeji Red Cross Hospital Medical Residency
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Awards (12):
- 2024/04 - 日本外科学会 若手外科医のための臨床研究助成 右側発症難治性大腸癌に対する最適化治療の確立
- 2023 - Japan Medical Women's Association Hiroko Yamamoto Award (International Award)
- 2021 - International Colorectal Research Summit Excellence Oral Presentation Award miR-221 Targets QKI5 and Enhances Functional Behaviors of Cancer Stem Cells in Human Colon Cancers
- 2021 - Japanese Cancer Association Young Investigator Award Comprehensive microRNA expression profiling utilizing clinical specimens of colon cancer and elucidating novel molecular mechanism regulating cancer stem cell functions.
- 2020 - Japanese Cancer Association Excellent Award for Women Scientists in Cancer Research CDX2 as a Prognostic and Predictive Biomarker in Colon Cancer.
- 2020 - Japan Medical Women’s Association Best Young Investigator Award
- 2019 - Japanese Surgeon Association Travel Grant Award CDX2 as a biomarker of colon cancer.
- 2019 - Hyogo Health Foundation Research Encouragement Award for Cancer Research
- 2018 - Kobe University, Department of Surgery Fujita Award (Best Paper Award) Evaluation of the Risk of Lymphomagenesis in Xenografts by the PCR-based Detection of EBV BamHI W region in Patient Cancer Specimens.
- 2017 - Japanese Association of Women in University Yasui Medical Scholarship Analysis of Molecular Mechanism of Cancer Metastasis By using orthotopic transplanted patient derived-tumor Xenograft of colorectal cancer
- 2016 - Kobe University Student Award of Excellence
- 2015 - Japanese Society of Gastroenterological Carcinogenesis Young Investigator Award, Japanese Society of Gastroenterological Carcinogenesis Establishment of effective treatment for colorectal cancer targeting cancer stem cell specific microRNAs
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