Rchr
J-GLOBAL ID:202201014142690324   Update date: Jun. 07, 2024

Takechi-Haraya Yuki

ハラヤ ユウキ | Takechi-Haraya Yuki
Affiliation and department:
Job title: Section Chief
Homepage URL  (1): https://scholar.google.com/citations?user=-H-trW8AAAAJ&hl=en
Research field  (2): Biophysics ,  Pharmaceuticals - analytical and physicochemistry
Research keywords  (6): リポソーム ,  nanoparticle ,  drug delivery ,  regulatory science ,  lipid membrane ,  peptide
Papers (47):
  • Yuki Takechi-Haraya. Atomic Force Microscopy to Measure the Mechanical Property of Nanosized Lipid Vesicles and Its Applications. YAKUGAKU ZASSHI. 2024. 144. 5. 511-519
  • Yuki Takechi-Haraya, Takashi Ohgita, Akiko Usui, Kazuchika Nishitsuji, Kenji Uchimura, Yasuhiro Abe, Ryuji Kawano, Monika I. Konaklieva, Mart Reimund, Alan T. Remaley, et al. Structural flexibility of apolipoprotein E-derived arginine-rich peptides improves their cell penetration capability. Scientific Reports. 2023. 13. 19396
  • Eiichi Yamamoto, Naoki Hosogi, Yuki Takechi-Haraya, Ken-ichi Izutsu, Nahoko Uchiyama, Yukihiro Goda. Folded, undulating, and fibrous doxorubicin sulfate crystals in liposomes. Nanomedicine: Nanotechnology, Biology and Medicine. 2023. 47. 102631
  • Yuki Takechi-Haraya, Akiko Usui, Ken-ichi Izutsu, Yasuhiro Abe. Atomic Force Microscopic Imaging of mRNA-lipid Nanoparticles in Aqueous Medium. Journal of Pharmaceutical Sciences. 2022. 112. 648-652
  • Zhi-Hong Yang, Kimball Nill, Yuki Takechi-Haraya, Martin P. Playford, David Nguyen, Zu-Xi Yu, Milton Pryor, Jingrong Tang, Krishna Vamsi Rojulpote, Nehal N. Mehta, et al. Differential Effect of Dietary Supplementation with a Soybean Oil Enriched in Oleic Acid versus Linoleic Acid on Plasma Lipids and Atherosclerosis in LDLR-Deficient Mice. International Journal of Molecular Sciences. 2022. 23. 8385
more...
MISC (3):
  • 原矢 佑樹. NIH留学記. 製剤機械技術学会誌. 2021. 30. 120
  • 原矢 佑樹. NIH での研究留学. 上原記念生命科学財団 海外留学だより. 2020
  • Yuki Takechi, Yuto Yanagisawa, Kazuchika Nishitsuji, Kenji Uchimura, Toru Kawakami, Kohsaku Kawakami, Keiichiro Okuhira, Hiroyuki Saito. Arginine-Glycosaminoglycan Interaction Regulates Penetration Efficiency of Arginine-Rich Cell-Penetrating Peptides in Biological Membrane. BIOPHYSICAL JOURNAL. 2015. 108. 2. 82A-82A
Books (1):
  • 新規モダリティ医薬品のための新しいDDS技術と製剤化
    技術情報協会 2023 ISBN:9784861049361
Lectures and oral presentations  (6):
  • AFMによるナノ構造体の特性解析
    (日本薬剤学会第39年会 2024)
  • 原子間力顕微鏡によるリポソームの特性解析とその応用
    (第20回次世代を担う若手のためのフィジカル・ファーマフォーラム (PPF2023) 2023)
  • 原子間力顕微鏡法を用いたナノ脂質膜小胞の力学的特性計測法の開発とその応用
    (日本薬学会第143年会 物理系薬学部会シンポジウム 2023)
  • Role of glycosaminoglycan interaction on direct cell membrane penetration of arginine-rich peptides
    (Wakayama Medical University International Symposium on Japan-France Glycopathophysiology 2022 2022)
  • Regulatory science research for the evaluation of nanomedicines at NIHS
    (11th European and Global Summit for Clinical Nanomedicine, Targeted Delivery and Precision Medicine (CLINAM 2018) 2018)
more...
Education (3):
  • 2012 - 2015 Tokushima University Graduate School of Pharmaceutical Sciences
  • 2009 - 2011 Tokushima University Graduate School of Pharmaceutical Sciences
  • 2005 - 2009 The University of Tokushima Faculty of Pharmaceutical Sciences School of Pharmacy
Professional career (1):
  • Ph.D. (Pharmaceutical Sciences) (Graduate School of Pharmaceutical Sciences, Tokushima University)
Work history (8):
  • 2024/04 - 現在 National Institute of Health Sciences Division of Biochemistry Section Chief
  • 2020/04 - 2024/03 National Institute of Health Sciences Division of Drugs Senior Scientist
  • 2020/10 - 2021/09 American University Department of Chemistry Visiting Scholar
  • 2020/10 - 2021/09 National Institutes of Health Lipoprotein Metabolism Section Research Fellow, Uehara Memorial Foundation
  • 2016/10 - 2020/03 National Institute of Health Sciences Division of Drugs Research Scientist
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Committee career (2):
  • 2022/04 - 現在 独立行政法人 医薬品医療機器総合機構 専門委員
  • 2022/04 - 現在 独立行政法人 医薬品医療機器総合機構 日本薬局方原案審議委員会 化学薬品委員会委員
Awards (10):
  • 2023/03 - 日本薬学会 物理系薬学部会 令和5年度日本薬学会物理系薬学部会奨励賞 原子間力顕微鏡法を用いたナノ脂質膜小胞の力学的特性計測法の開発とその応用
  • 2020/03 - 上原記念生命科学財団 海外留学助成リサーチフェローシップ ペプチドナノディスクによる新規動脈硬化治療法の開拓
  • 2019/10 - 日本ペプチド学会 第56回ペプチド討論会ポスター賞
  • 2019/09 - 日本薬学会レギュラトリーサイエンス部会 第5回次世代を担う若手のためのレギュラトリーサイエンスフォーラム 優秀発表賞
  • 2017/05 - Young Scientist Award of The Membrane Society of Japan
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Association Membership(s) (6):
Sigma Xi ,  The Academy of Pharmaceutical Science and Technology, Japan ,  The Japan Society of Drug Delivery System ,  The Membrane Society of Japan ,  The Pharmaceutical Society of Japan ,  日本ペプチド学会
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