Nakabeppu Yusaku

2014 - 2017 Molecular mechanism of degeneration of dopaminergic neurons caused by 8-oxoguanine

2014 - 2017 Function of histone methyltransferase PR-set7 and its relationship to carcinogenesis

2013 - 2016 hTFAM improves impaired insulin signaling in Alzheimer's disease

2011 - 2015 Basic and clinical study of EGFR gene mutation-positive lung cancer using a genetically modified mouse

2010 - 2014 環境ストレスによるヌクレオチドプールの恒常性破綻の分子病態と制御機構の解明

2013 - 2014 Galectin-1による筋萎縮性側索硬化症の発症と進行の二面的制御

2011 - 2013 Analysis of chromatin function mediated by histone H4 lysine 20 methylation

2011 - 2013 Study of Pathological Mechanism in Light Induced Retinal Damage using DNA Base Excision Repair Gene Knockout Mice

2011 - 2012 Regulatory mechanisms of brain function by alternative splicing products of fosB gene

2010 - 2012 Development of apomorphine therapy for Alzheimer disease

2010 - 2012 Regulation of MUTYH expression by p53 plays a critical role in cell death

2008 - 2009 Genomic damage and cancer cell death caused by reactive oxygen species

2007 - 2009 Disorder of reward circuit in bipolar disorders : integration of basic and clinical investigation

2007 - 2009 Molecular and phathobiological analysis of defects in quality control systems for DNA and free nucleotides by using mouse models

2006 - 2007 酸化的ストレスによる細胞死と消化管がん抑制機構におけるMUTYHの働き

2006 - 2007 Roles of the defense mechanisms against oxidative damage in nucleic acids for maintenance of brain cells

2004 - 2006 Molecular pathological analysis of defects in DNA base excision repair system using gene modified mice

2005 - 2005 酸化的ストレスによる細胞死と消化管がん抑制機構におけるMUTYHの働き

2004 - 2004 ゲノム多型及び遺伝病の成因としての自然DNA酸化損傷とその修復機構の破綻

2003 - 2004 The sanitizing systems for endogenous nucleotide lesions, and their roles on spontaneous mutagenesis

2002 - 2004 Establishment of detectional system of individual tumor markers

2002 - 2004 Role of oxidative mitochondrial DNA damage and its preventive mechanisms in the development and progression of heart failure

2000 - 2004 Oxidative DNA damage-induced tumorigenesis and its avoidance mechanism

2003 - 2003 ヒト癌におけるMTH1発現亢進の意義の解明とMTH1の発現・機能抑制法の開発

2001 - 2002 Implication of oxidized nucleotides in spontaneous mutation and their sanitizing systems

2001 - 2002 Study on oxidative DNA damage and repair enzyme in acute and chronic renal disease

1999 - 2001 Study of Defense Mechanisms against Cellular Damage Caused by Free Radicals

1999 - 2000 The total analyses of the mechanism of the invasion and metastasis in human oral squamus cell carcinoma by the transcriptional factors

1999 - 2000 Analysis of the regulated mechanisms of cell proliferation and apoptosis in the endometrium at AP-1 binding site

1999 - 2000 アルツハイマー病の細胞内Aβ42誘導性ニューロンアポトーシス死の分子メカニズム

1998 - 2000 Oxygen-induced DNA damage and its repair mechamism

1998 - 2000 DNA Repair Mechanisms Protecting Brain and Neuronal Cells from Damage Caused by Reactive Oxygen Species

1998 - 1998 プロトオンコジーンfosBによる細胞増殖と細胞死の制御機構の解析

1998 - 1998 活性酸素による神経細胞死とその防御機構の解析

1997 - 1997 Repair of alkylation DNA damage

1997 - 1997 ヒト発がんにおける複製・修復遺伝子の変異

1997 - 1997 ヒトMTH1蛋白質の発現制御と突然変異抑制機能の解析

1997 - 1997 活性酸素による神経細胞死とその防止機構の解析

1996 - 1997 Development of an Effecient System for Gene Targeting

1997 - 活性酸素によるゲノム障害とその防御機構の解明

1997 - Studies on Mechanisms Protecting Genomic Integrity from Damage Caused by Reactive Oxygen Species.

1996 - 1996 転写制御遺伝子群の発癌への関与

1996 - 1996 哺乳動物における酸素ラジカルによる自然突然変異とその抑制機構

1995 - 1995 転写制御遺伝子群の発癌への関与

1995 - 1995 Active Oxygen-induced DNA Damage and its Repair Mechanisms

1993 - 1995 Molecular Mechanisms of Differentiation and Proliferation Switches

1994 - 1994 転写制御遺伝子群の発癌への関与

1994 - 1994 Oxygen-induced DNA Damage and its Repair Mechanisms

1994 - 1994 ΔFosBによる細胞複製の制御

1994 - 1994 fosB遺伝子による細胞のがん化と遺伝子発現制御

1993 - 1993 △FosBによる細胞の癌化と遺伝子発現

1993 - 1993 Fos,Junによる細胞複製の制御

1993 - 1993 FosBおよび△FosBによる細胞分化の制御

1991 - 1993 O^6-アルキルグアニン-アルキル転移酵素の制がんと発がんにおける役割

1991 - 1993 Information Exchange on Cancer Research with North American Countries.

1992 - 1992 Fos,Junの標的遺伝子の検索

1992 - 1992 Fos,Junによる細胞複製の制御

1991 - 1992 O^6-アルキルグアニン-アルキル転移酵素の制がんと発がんにおける役割

1990 - 1992 Molecular mechanisms of the adaptive response to alkylating agents

1991 - 1991 O^6ーアルキルグアニンーアルキル転移酵素の制がんと発がんにおける役割

1991 - 1991 Jun/Fos複合体(APー1)による細胞複製の制御

1986 - 1990 Maintenance of Genetic Information and Mutagenesis Mechanisms

幹細胞の維持機構

発癌モデルマウスの作製

神経変性疾患モデルマウス作製

微量修飾核酸の検出法の開発

Generation of mouse model for tumorigenesis

Generation of mouse model for neurodegenerative disorders

Development of detection methods for minor modified nucleic Acids