J-GLOBAL ID:200901004353084228   Update date: Nov. 13, 2019

Uwai Koji

ウワイ コウジ | Uwai Koji
Affiliation and department:
Job title: Associate Professor
Homepage URL  (2): http://www3.muroran-it.ac.jp/biocathttp://www3.muroran-it.ac.jp/biocat
Research field  (3): Chemical biology ,  Bio-related chemistry ,  Natural medicines
Research keywords  (5): bioactive compound ,  amyloid-beta ,  Alzheimer's disease ,  biocatalyst ,  enzyme
Research theme for competitive and other funds  (4):
  • 2018 - 2019 北海道産農作物の核磁気共鳴法による認知機能低下予防活性スクリーニング
  • 2016 - 2018 シソ科植物の成分基づく新規アミロイドβ凝集阻害物質の開発とその分子機構
  • 2015 - 2016 微量ハイスループットスクリーニング法を利用したアオジソ含有Aβ凝集阻害物質の探索
  • 2004 - 2006 化学および生物学的手法による不斉酸化反応を触媒する薬物代謝酵素の単離とその応用
Papers (88):
  • Rina Sasaki, Kenji Monde, Koji Uwai, Kiyotaka Tokuraku. Development of an automated microliter-scale highthroughput screening system with quantum-dot nanoprobes for amyloid aggregation inhibitors. Symposium papaer of Joint Seminar on Environmental Science and Disaster Mitigation Research 2019. 2019. 116-117
  • Masahiro Kuragano, Mamoru Fukuchi, Koji Uwai, Kiyotaka Tokuraku. Synergistic effects of inhibition of amyloid β aggregation and induction of brain-derived neurotrophic factor (BDNF) activity on mitigation of neurocytotoxicity by amyloid β. Symposium paper of Joint Seminar on Environmental Science and Disaster Mitigation Research 2019. 2019. 68-69
  • Shinji Matsuzaki, Koji Uwai, Shinya Yamanaka, Kiyotaka Tokuraku. Biological evaluation of disinfecting effects of slaked limebased disinfectants for prevention of livestock infectious diseases. Symposium paper of Joint Seminar on Environmental Science and Disaster Mitigation Research 2019. 2019. 66-67
  • Sasaki, R., Tainaka, R., Ando, Y., Hashi, Y., Virupaksha D.H., Suga, Y., Murai, Y, Anetai, M., Monde, K., Ota, K., Ito, I., Kikuchi, H., Oshima, Y., Endo, Y., Nakao, H., Sakono, M., Uwai, K., and Tokuraku. An automated microliter-scale high-throughput screening system (MSHTS) for real-time monitoring of protein aggregation using quantum-dot nanoprobes. Scientific Reports. 2019. 9
  • Isiaka A. Owolabi, Madhu Chennapuram, Chigusa Seki, Yuko Okuyama, Eunsang Kwon, Koji Uwai, Michio Tokiwa, Mitsuhiro Takeshita, Hiroto Nakano. Amino Amide Organocatalysts for Asymmetric Michael Addition of β-Keto Esters with β-Nitroolefins. Bull. Chem. Soc. Jpn. 2019. 92. 696-701
MISC (3):
  • 田口 莉帆,上井 幸司,東 陽介,箕輪 貴司. シソ科植物由来阻害物質によるアミロイドβタンパク質凝集阻害機構の円二色性スペクトルを用いた解析. NanotechJapan Bulletin ナノテクノロジーPick Up企画 第9回. 2017. 10. 6
  • 徳樂清孝、上井幸司. 量子ドットナノプローブを用いたアミロイド凝集過程のリアルタイムイメージング技術とその活用. 第54回粉体に関する討論会講演論文集. 2016
  • 上井幸司. 微量ハイスループットスクリーニング法を利用したアオジソ含有Aβ凝集阻害物質の探索. 秋山財団年報. 2016. 29. 74-74
Patents (5):
  • 消毒剤
  • 消毒剤
Books (1):
  • BIO Clinica
    北隆館 2016
Lectures and oral presentations  (263):
  • Exploring the Structural Basis of Neurotoxicity in C17-Polyacetylenes Isolated from Water Hemlock
    (PACIFICHEM 2000 2000)
  • Stereoselective Oxidation of the Sulfur Compounds by Rat Liver S-9 Fraction
    (The 10th Japan-Korea Joint Symposium on Drug Design and Development 2004)
  • Purification and Characterization of 4-Acetylpyridine Carbonyl Reductase from Rat Liver
    (The 17th French-Japanese Symposiumon Medicinal and Fine Chemistry 2004)
  • Stereoselective Oxidation of the Sulfides byRat Liver S-9 Fraction
    (The 17th French-Japanese Symposium on Medicinal and Fine Chemistry 2004)
  • Asymmetric redox reactions ofbenzylic position of various aromatic compounds by rat liver S-9 fraction
    (Pharmaceutical Sciences World Congress (PSWC2004) 2004)
Education (3):
  • - 1995 Tohoku University Faculty of Pharmaceutical Science Department of Pharmaceutical Sciences
  • - 1997 Tohoku University Graduate School, Division of Pharmaceutical Sciences 立体創薬化学
  • - 2000 Tohoku University Graduate School, Division of Pharmaceutical Sciences Pharmaceutical Sciences
Professional career (1):
  • Ph.D (Tohoku University)
Committee career (2):
  • 2017/04/01 - 2018/03/31 日本化学会北海道支部 支部役員
  • 2013/04/01 - 2014/03/31 日本化学会北海道支部 支部役員
Awards (4):
  • 2016/09/01 - EPAM2016 Best Presentation Award
  • 2014/11/10 - Outstanding Poster Award in The 5th Forum on Studies of the Environmental and Public Health Issues in the Asian Mega-cities (EPAM 2014)
  • 2013/09/22 - 日本医療薬学会 日本医療薬学会論文賞
  • 2011/12/22 - 第十五回生体触媒化学シンポジウム実行委員会 第十五回生体触媒化学シンポジウム ポスター賞
Association Membership(s) (9):
The chemical society of Japan ,  The Pharmaceutical Society of Japan ,  The Japanese Society for the Study of Xenobiotics ,  The Society of Biotechnology, Japan ,  Japanese Society of Food Chemistry ,  Japan Society for Demantia Research ,  The Society of Biocatalysis Japan ,  日本核磁気共鳴学会 ,  The Japan Society for Bioscience, Biotechnology, and Agrochemistry (JSBBA)
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