Rchr
J-GLOBAL ID：200901004687741351
Update date: Oct. 12, 2024
Inokuchi Jin'ichi
イノクチ ジンイチ | Inokuchi Jin'ichi
Affiliation and department：
Job title：
Professor
Other affiliations (1)：
-
Tohoku Medical and Pharmaceutical University
Institute of Molecular Biomembrane and Glycobiology
Visiting Professorc
Homepage URL (2)：
https://www.frc.sci.osaka-u.ac.jp/about-us/organization
,
https://www.frc.sci.osaka-u.ac.jp/en/
Research field (2)：
Pharmacology
, Functional biochemistry
Research keywords (4)：
chronic inflammation
, glycoimmunology
, glycosphingolipid
, マイクロドメイン
Research theme for competitive and other funds (26)：
- 2022 - 2025 海洋動物レクチンを細胞内に取り込む分子機序とそれを利用した新規がん治療法の開発
- 2020 - 2024 New paradigm for the regulation of chronic inflammation by glycosphingolipids
- 2017 - 2020 腸管免疫機構と炎症性腸疾患の病因・病態におけるガングリオシドの機能解明
- 2017 - 2019 New paradigm for innate immune regulatory mechanism and chronic inflammation mediated by ganglioside molecular species
- 2016 - 2019 Elucidation of a novel inflammation amplification loop by ganglioside molecular species
- 2014 - 2016 聴覚におけるガングリオシドの機能解明
- 2011 - 2014 Emerging pathophysiological roles of ganglioside GM3
- 2009 - 2011 Involvement of insulin resistance-associated ganglioside GM3 in the pathogenesis of bronchial asthma.
- 2007 - 2008 Pharmacological studies in accelerating mechanism of Alzheimer's disease by diabetes mellitus with insulin resistance in rats
- 2006 - 2007 ガングリオシドGM3合成酵素遺伝子診断による非小細胞肺癌の抗癌剤感受性の予測
- 2004 - 2005 A research of regulation of glycosphingolipids gene expression and anticancer drug sensitivity in human oral cancer cell lines
- 2003 - 2004 癌および2型糖尿病の病態とスフィンゴ糖脂質マイクロドメイン
- 2003 - 2004 Involvement of ganglioside in lifestyle-related disease and cancer, and the development of new diagnostic method and therapeutic strategy
- 2000 - 2004 スフィンゴシン1-リン酸とその受容体の情報伝達機構と生理機能の解析
- 1999 - 2001 The protective effects of sphingolipid synthetic drug (L-PDMP) on apoptotic cell damage in cerebral infarction
- 1999 - 2001 Studies on neuronal functions by modulators of glycosphingolipid synthesis
- 2000 - 2000 ガングリオシド発現調節による大脳皮質シナプス機能および神経分化に関する研究
- 1999 - 2000 Biological functions of a lipid mediator, sphingosine 1-phosphate
- (]G0002[)型糖尿病におけるインシュリン抵抗性発症におけるガングリオシドの関与
- 癌・糖尿病におけるスフィンゴ糖脂質マイクロドメインの機能
- 糖脂質生合成促進物質を用いた神経疾患治療に対する基礎的検討。
- ガングリオシドの神経機能(特にシナプス機能と記憶形成過程)の研究
- Role of Ganglioside in Insulin Resistance of type 2 Diabetes
- Roles of Glycosphingolipid Microdomain in cancer and Type 2 Diabetes
- Application of stimulator of glycosphingolipid Biosynthesis for the treatment of neurological disorders
- Elucidation of functional roles of gangliosides in synaptic function and memory formation
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Papers (220)：
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Inamori Kei-ichiro, Kanoh Hirotaka, Nitta Takahiro, Inokuchi Jin-ichi. Regulation of glycosphingolipid functions by structural diversity of ceramide moiety. 2024. 96. 4. 448-456
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稲森 啓一郎, 宍戸 史, 許 家甄, 永福 正和, 新田 昂大, 中村 勝哉, 土田 奈緒美, 池田 淳司, 小平 農, 栂谷内 晶, et al. 神経変性症患者および一般住民に見出された新規B4GALNT1(GM2合成酵素)バリアントの機能解析. 脂質生化学研究. 2024. 66. 238-240
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Go Anan, Takahiro Nitta, Hirotaka Kanoh, Makoto Sato, Jin-Ichi Inokuchi. Perioperative changes in ganglioside monosialodihexosylganglioside (GM3) molecular species for benign prostatic hyperplasia: a preliminary report. Translational andrology and urology. 2024. 13. 1. 104-108
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Jin-Ichi Inokuchi, Shinji Go, Akemi Suzuki, Osamu Nakagawasai, Takayo Odaira-Satoh, Lucas Veillon, Takahiro Nitta, Paul McJarrow, Hirotaka Kanoh, Kei-Ichiro Inamori, et al. Dietary gangliosides rescue GM3 synthase deficiency outcomes in mice accompanied by neurogenesis in the hippocampus. Frontiers in neuroscience. 2024. 18. 1387221-1387221
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Eriko Aoki, Noriyoshi Manabe, Shiho Ohno, Taiga Aoki, Jun-Ichi Furukawa, Akira Togayachi, Kiyoko Aoki-Kinoshita, Jin-Ichi Inokuchi, Kenji Kurosawa, Tadashi Kaname, et al. Predicting the pathogenicity of missense variants based on protein instability to support diagnosis of patients with novel variants of ARSL. Molecular Genetics and Metabolism Reports. 2023. 37. 101016-101016
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MISC (135)：
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樺山一哉, 樺山一哉, 樺山一哉, 黄栩昊, 狩野裕考, 井ノ口仁一, 深瀬浩一, 深瀬浩一, 深瀬浩一. スフィンゴミエリン分子種によるインフラマソーム制御機構の解明. 脂質生化学研究. 2024. 66
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HUANG Xuhao, 樺山一哉, 樺山一哉, 狩野裕考, 井ノ口仁一, 深瀬浩一, 深瀬浩一. Modulation of inflammation and cell death responses by sphingomyelin molecular species. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
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井ノ口仁一, 狩野裕考, 新田昂大, 稲森啓一郎, 石川潮, 樺山一哉, 黄栩昊, 下山敦史, 深瀬浩一. GM3分子種によるTLR4及びCaspase4/11の活性化制御. 日本生化学会大会(Web). 2023. 96th
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中村 勝哉, 土田 奈緒美, 井ノ口 仁一, 小島 朋美, 池田 淳司, 小平 農, 稲森 啓一郎, 永福 正和, 新田 昂大, 真鍋 法義, et al. 本邦初のB4GALNT1関連神経変性症の臨床的特徴. 臨床神経学. 2022. 62. Suppl. S208-S208
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狩野裕考, 新田昂大, 井ノ口仁一. GM3 ganglioside-mediated control of TLR4 signaling. 月刊メディカル・サイエンス・ダイジェスト. 2022. 48. 1
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Lectures and oral presentations (39)：
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GM3 ganglioside ln insulin resistance and inflammation
(International Endotoxin and Innate Immunity Society 2021)
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Homeostatic and Pathogenic Roles of Ganglioside GM3
(WEBINAR SERIES ON SPHINGILOPID BIOLOGY -SphingoLeader Lecture- 2020)
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Homeostatic and Pathogenic Roles of Ganglioside GM3 molecular species in TLR4 signaling
(12th International Symposium on Glycosyltransferases, Glyco-T 2020 2020)
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Homeostatic and Pathogenic Roles of Ganglioside GM3 Molecular Species in TLR4 Signaling
(FEBS Special Meeting 2019 Sphingolipid Biology: Sphingolipids in Physiology and Pathology 2019)
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New Paradigm for Chronic Inflammation Mediated by Glycosphingolipids.
(MicrobiotaMi2018 2018)
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Education (3)：
- - 1979 Fukuoka University Division of Pharmaceutical Sciences
- - 1977 Fukuoka University Faculty of Pharmaceutical Sciences Department of Pharmaceutics
- - 1977 Fukuoka University Faculty of Pharmaceutical Science
Professional career (1)：
Work history (9)：
- 2023/04 - 現在 Tohoku Medical and Pharmaceutical University Institute of Molecular Biomembrane and Glycobiology Visiting Professorc
- 2022/10 - 現在 Osaka University Graduate School of Science Project Research Center for Fundamental Sciences Specially-appointed Professor
- 2019/04 - 2023/03 Tohoku Medical and Pharmaceutical University Institute of Molecular Biomembrabe and Glycobiology Specially-Appointed Professor
- 2021/04 - 2022/09 Osaka University Graduate School of Science,Forefront Research Center (FRC) Invited Professor
- 2016/04 - 2018/03 Tohoku Medical and Pharmaceutical University Division of Glycopathology, Insitute of Molevular Biomembrane and Glycobiology professor
- 2006/04 - 2016/03 Tohoku Pharmaceutical University Division of Glycopathology, Institute of Molecular Biomembrane and Glycobiology Professor
- 1998/04 - 2006/03 Associate Professor, Grad. Sch. of Pharm. Sci, Hokkaido Univ
- 1991/12 - 1998/03 生化学工業(株)東京研究所 主任研究員
- 1979 - 1991 Fukuoka University Faculty of Pharmaceutical Sciences
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Committee career (8)：
- 2018/04 - 現在 Japan Consortium For Glycobiology & Glycotechnology (JCGG) Standing secretary
- 2016/10 - 現在 Tohoku Glycoscience Forum President
- 2015/12 - 現在 The Japanese Society of Carbohydrate Research (JSCR) Secretary
- 2008/04 - 現在 Council member
- 1999/04 - 現在 Japan Consortium For Biology of Lipids Council member
- 2005/01 - 2023/08 Asian Society for Glycoscience and Glycotechnology (ACGG) Steering Committee Member
- 2006/04 - 2023/03 The Japanese Biochemical Society Council member
- 2018/04 - 2020/03 The Pharmaceutical Society of Japan member of brad of trustees
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Association Membership(s) (5)：
Japanese Society for Immunology
, 日本脂質生化学会
, 日本糖質学会
, 日本生化学会
, 日本薬学会
