Rchr
J-GLOBAL ID：200901007635486549
Update date: Apr. 02, 2024
Kawabata Atsufumi
カワバタ アツフミ | Kawabata Atsufumi
Affiliation and department：
Job title：
Professor
Homepage URL (1)：
http://www.phar.kindai.ac.jp/byoutai/
Research field (2)：
Pharmacology
, Pharmaceuticals - health and biochemistry
Research keywords (6)：
ラジカル
, プロテアーゼ
, 受容体
, Radical
, Protease
, Receptor
Research theme for competitive and other funds (20)：
- 2023 - 2026 The role of change in expression levels of coagulation factors in Schwann cells in the neuropathic pain
- 2021 - 2024 血栓止血系分子とHMGB1の相互干渉による疼痛制御のメカニズムと臨床的意義の解明
- 2020 - 2023 内因性硫化水素合成阻害による抗がん剤の有効性増大と副作用軽減の可能性について
- 2017 - 2020 Novel therapeutic strategy targeting RAGE for treatment of peripheral neuropathy and visceral pain
- 2014 - 2017 Roles of T-type calcium channels and calcineurin in inflammatory or neuropathic pain
- 2014 - 2017 Prevention and treatment of chemotherapy-induced neuropathic pain and visceral pain by targeting HMBG1, a nuclear protein
- 2011 - 2013 Study of roles of endogenous hydrogen sulfide in stomach with mucosal injury
- 2011 - 2013 Pain regulation by PKA and calcineurin through functional modulation of T-type calcium channels
- 2008 - 2010 Study on effects of Helicobacter pylori infection on expression and function of proteinase-activated receptors in gastric mucosal epithelium.
- 2008 - 2010 Involvement of the gasotransmitter hydrogen sulfide in neurogenic pain
- 2005 - 2007 Roles for hydrogen sulfide, a novel endogenous gasotransmitter, in nociceptive processing
- 2001 - 2003 Study on roles for PAR-2, a G protein-coupled receptor, in acute inflammation
- 2000 - 2001 STUDY ON CORTICAL STIMULATION-EVOKED ANALGESIA IN PERSISTENT PAIN MODELS
- 1999 - 2000 ROLES OF PROTEASE-ACTIVATED RECEPTORS IN THE ALIMENTARY SYSTEMS : PARTICIPATION IN THE MODULATION OF FUNCTIONS IN THE SALIVARY GLANDS, PANCREAS AND SMALL INTESTINE
- 1998 - 1999 Analgesia produced by cortical electrical stimulation and its modification by inhibition of NO synthase
- 1993 - 1993 疼痛制御におけるL-アルギニンの役割:NO系とキョ-トルフィン系の関与
- プロテアーゼ受容体に関する研究
- 疼痛制御メカニズムに関する研究
- Study on protease-activated receptors
- Study on pain modulation systems.
Show all
Papers (185)：
-
Shiori Iwane, Wataru Nemoto, Tomoyoshi Miyamoto, Tomonori Hayashi, Masayuki Tanaka, Kazuki Uchitani, Tatsuya Muranaka, Masanori Fujitani, Yuichi Koizumi, Atsushi Hirata, et al. Clinical and preclinical evidence that angiotensin-converting enzyme inhibitors and angiotensin receptor blockers prevent diabetic peripheral neuropathy. Scientific Reports. 2024. 14. 1
-
Yoshihito Kasanami, Takashi Yamamoto, Tomoyoshi Miyamoto, Sumio Matzno, Mikio Sakakibara, Masahiro Iwaki, Atsufumi Kawabata. Characterization of Potentially Inappropriate Medications That Need Special Attention in the Elderly with Dementia by Analyzing Pharmacy Claims Data. Biological and Pharmaceutical Bulletin. 2023. 46. 12. 1699-1705
-
Shiori Tomita, Fumiko Sekiguchi, Katsuki Naoe, Shiyu Shikimi, Yoshihito Kasanami, Maya Ohigashi, Maho Tsubota, Atsufumi Kawabata. Cav3.2-dependent hyperalgesia/allodynia following intrathecal and intraplantar zinc chelator administration in rodents. Journal of pharmacological sciences. 2023. 152. 2. 86-89
-
Fumiko Sekiguchi, Nene Koike, Yasuhiro Shimada, Kaho Sugimoto, Hiroshi Masuda, Takashi Nakamura, Hiroaki Yamaguchi, Genzoh Tanabe, Shinsuke Marumoto, Yoshihito Kasanami, et al. A hydrolysate of poly-trans-[(2-carboxyethyl)germasesquioxane] (Ge-132) suppresses Cav3.2-dependent pain by sequestering exogenous and endogenous sulfide. Redox biology. 2023. 59. 102579-102579
-
Takashi Maeda, Fumiko Sekiguchi, Kenji Mitani, Ryosuke Yamagata, Maho Tsubota, Shigeru Yoshida, Atsufumi Kawabata. Opioid modulation of T-type Ca2+ channel-dependent neuritogenesis/neurite outgrowth through the prostaglandin E2/EP4 receptor/protein kinase A pathway in mouse dorsal root ganglion neurons. Biochemical and biophysical research communications. 2023. 639. 142-149
ｍore...
MISC (347)：
-
冨田詩織, 冨田詩織, 根本亙, 宮本朋佳, 宮本朋佳, 林友典, 田中雅幸, 打谷和記, 村中達也, 小泉祐一, et al. Effects of angiotensin converting enzyme inhibitors or receptor blockers on diabetic peripheral neuropathy: clinical evidence supported by a preclinical study. 日本薬学会年会要旨集(Web). 2023. 143rd
-
圓尾賢悟, 池田裕哉, 坪田真帆, 王登莉, 西堀正洋, 南達郎, 伊藤彰敏, 川畑篤史. 活性化プロテインCは神経障害性疼痛を抑制する:Proteinase-activated receptor-1(PAR1)の関与について. 生体機能と創薬シンポジウム要旨集. 2022. 2022
-
冨田詩織, 冨田詩織, 宮本朋佳, 宮本朋佳, 田中雅幸, 打谷和記, 小泉祐一, 村中達也, 根本亙, 丹野孝一, et al. アンギオテンシン変換酵素阻害薬とアンギオテンシンII受容体拮抗薬は糖尿病性末梢神経障害の発症を抑制する:臨床・基礎融合研究によるエビデンス. 生体機能と創薬シンポジウム要旨集. 2022. 2022
-
圓尾賢悟, 坪田真帆, 田島和樹, 関口富美子, 西堀正洋, 南達郎, 伊藤彰敏, 川畑篤史. Thrombomodulin alfaのoxaliplatin誘発性末梢神経障害抑制作用発現におけるHMGB1不活性化とprotein C及びTAFI活性化の相対的重要性と下流シグナル分子の解析. 日本薬理学雑誌. 2022. 157. Supplement
-
堂本莉紗, 田村ひなの, 関口富美子, 坪田真帆, 西堀正洋, 川畑篤史. 抗リウマチ薬sulfasalazineはマクロファージからのHMGB1遊離を抑制することでlipopolysaccharide誘起アロディニアを抑制する. 日本薬理学雑誌. 2022. 157. Supplement
ｍore...
Patents (30)：
Books (10)：
-
H2S and pain: a novel aspect for processing of somatic, visceral and neuropathic pain signals. In Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide, edited by Moore, P.K. and Whiteman, M.
Springer 2015
-
詳解薬理学
廣川書店 2015 ISBN:9784567495103
-
Disseminated intravascular coagulation (DIC)-like events produced by environmental stress and by lipopolysaccharide : Nitric oxide as a common key molecule.
The Biology of Nitric Oxide Part 6(Portland Press, London) 1998
-
NOの疼痛制御における役割の多様性
医学のあゆみ別冊「NOのすべて」 1996
-
Multiplicity of the role of nitric oxide in pain modulation
1996
ｍore...
Lectures and oral presentations (331)：
-
活性化protein Cはproteinases-activated receptor 1 を介して神経障害性疼痛を抑制する
(第96回日本薬理学会年会)
-
定型抗精神病薬pimozideの構造展開により開発した新規T型Ca2+チャネル阻害薬KTtp38:チャネル選択性、電気生理学的特徴、鎮痛活性の評価
(第96回日本薬理学会年会)
-
マウスにおける補体アナフィラトキシンC5a誘起アロディニアの発現メカニズムについて
(第96回日本薬理学会年会)
-
H2SおよびATP補捉作用を有するrepagermanium (Ge-132) はマウスにおけるパクリタキセル誘発性末梢神経障害を抑制する
(第96回日本薬理学会年会)
-
オキサリプラチン誘起末梢神経障害(OIPN)への血小板由来HMGB1の関与:抗血小板薬のOIPN予防効果について
(第96回日本薬理学会年会)
ｍore...
Education (4)：
- - 1985 Kindai University
- - 1985 Kinki University Graduate School, Division of Pharmaceutical Sciences
- - 1983 Kindai University Faculty of Pharmacy
- - 1983 Kinki University Faculty of Pharmaceutical Science
Professional career (2)：
Committee career (2)：
Awards (2)：
- 2000 - 日本薬学会近畿支部奨励賞
- 1998 - Annual Award 1998 of The Pharmacological Society of Canada
Association Membership(s) (3)：
Return to Previous Page
