Fukai Shuya

フカイシユウヤ | Fukai Shuya

Affiliation and department：
Job title： Professor
Homepage URL (2)： http://kuchem.kyoto-u.ac.jp/kozo/index.html , http://kuchem.kyoto-u.ac.jp/kozo/index_en.html

Research field (1)： Structural biochemistry

Research keywords (2)：構造生物化学 , Structural biological chemistry

Research theme for competitive and other funds (18)：

2018 - 2023 Ubiquitin structural biology providing the molecular basis for chemo-technologies
2018 - 2023 New frontier for ubiquitin biology driven by chemo-technologies
2018 - 2022 Structural analysis of the epilepsy-related protein complex LGI1-ADAM22-PSD-95 and its regulatory factors
2015 - 2018 BRCC36複合体によるK63結合型ユビキチン鎖特異的切断メカニズムの解明
2012 - 2016 Structural basis for ubiquitin chain-mediated DNA damage responses

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Papers (87)：

Takafumi Furuhata, Bumkyu Choi, Taiki Uno, Ryota Shinohara, Yusuke Sato, Kei Okatsu, Shuya Fukai, Akimitsu Okamoto. Chemical Diversification of Enzymatically Assembled Polyubiquitin Chains to Decipher the Ubiquitin Codes Programmed on the Branch Structure. Journal of the American Chemical Society. 2024
Erika Tsutsumi, Satomi Niwa, Ryota Takeda, Natsuki Sakamoto, Kei Okatsu, Shuya Fukai, Hideo Ago, Satoshi Nagao, Hiroshi Sekiguchi, Kazuki Takeda. Structure of a putative immature form of a Rieske-type iron-sulfur protein in complex with zinc chloride. Communications Chemistry. 2023. 6. 1. 190-190
Shoun Taguchi, Satomi Niwa, Hoang-Anh Dao, Yoshihiro Tanaka, Ryota Takeda, Shuya Fukai, Kazuya Hasegawa, Kazuki Takeda. Detailed analysis of distorted retinal and its interaction with surrounding residues in the K intermediate of bacteriorhodopsin. Communications Biology. 2023. 6. 1
Atsushi Yamagata, Yoshiko Murata, Kosuke Namba, Tohru Terada, Shuya Fukai, Mikako Shirouzu. Uptake mechanism of iron-phytosiderophore from the soil based on the structure of yellow stripe transporter. Nature Communications. 2022. 13. 1. 7180-7180
Takeshi Uemura, Emi Suzuki-Kouyama, Shiori Kawase, Taiga Kurihara, Misato Yasumura, Tomoyuki Yoshida, Shuya Fukai, Maya Yamazaki, Peng Fei, Manabu Abe, et al. Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins. Cell Reports. 2022. 39. 1. 110624-110624

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MISC (16)：

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Lectures and oral presentations (35)：

Identification of Peptidic Inhibitors Targeting p97-hUfd1-hNpl4 Complex
(日本薬学会年会要旨集(Web) 2022)
炎症シグナルタンパク質TAB2のNZFドメインによるK6結合型ユビキチン鎖認識の構造基盤
(日本蛋白質科学会年会プログラム・要旨集 2022)
ケモテクノロジーが拓くユビキチンニューフロンティアヒトDUBアレイ技術を用いたUSP特異的阻害剤の開発
(日本生化学会大会プログラム・講演要旨集 2020)
ユビキチンリガーゼUBE3Aは26Sプロテアソームの負の調節因子である
(日本分子生物学会年会プログラム・要旨集(Web) 2020)
PINK1 activation by its unconventional localization to the outer mitochondrial membrane
(日本分子生物学会年会プログラム・要旨集(Web) 2019)

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Education (2)：

- 2002 The University of Tokyo
- 1997 The University of Tokyo Faculty of Science Department of Biophysics and Biochemistry

Professional career (1)：

Work history (7)：

2020/03 - 現在 Kyoto University Department of Chemistry, Graduate School of Science Professor
2018/04 - 2020/02 The University of Tokyo Institute for Quantitative Biosciences Associate Professor
2016/12 - 2018/03 The University of Tokyo Institute of Molecular and Cellular Biosciences Associate Professor
2007/05 - 2016/11 The University of Tokyo Organization for Synchrotron Radiation Research Associate Professor
2006/04 - 2007/05 Tokyo Institute of Technology Center for Biological Resources and Informatics Associate Professor

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