Rchr
J-GLOBAL ID:200901008797601429
Update date: Jul. 17, 2024
Yasui Manabu
Yasui Manabu
Affiliation and department:
Job title:
Researcher
Homepage URL (1):
http://www.nihs.go.jp/dgm/index.html
Research field (2):
Environmental effects of chemicals
, Environmental effects of radiation
Research keywords (8):
Gene mutation
, 環境リスク
, 化学発がん
, 環境変異原
, 突然変異
, Chemical carcinogenesis
, DNA adduct
, Mutagenesis
Research theme for competitive and other funds (13):
- 2021 - 2024 透析膜を利用した新しい代謝活性化システムによるDNA付加体の形成と同定
- 2019 - 2022 Quantum chemical challenge to elucidate the functional mechanism of base sequence specificity deciding removal of the DNA damage
- 2016 - 2021 Establishment of Novel Bioassays for in vivo Genotoxicity Prediction and Mechanism Characterization
- 2013 - 2019 Construction of a DNA double-strand break model and its application to studies of DNA repair and low dose irradiation effects
- 2013 - 2019 Site-specific gene mutagenesis involving a single DNA adduct in vivo
- 2010 - 2014 Studies on mechanisms underlying genotoxic thresholds through genetic modification of DNA polymerase zeta
- 2010 - 2012 Development of a single DNA adduct-caused gene mutation assay as a model of low-dose exposure
- 2007 - 2008 Mutation mechanism of a single DNA adduct embedded in human genomeof TK6 cells
- 2002 - 2003 ホルムアルデヒドによって誘発されるDNA付加体の定量法の開発
- 染色体異常生成のライブセルイメージング
- DNA付加体による突然変異誘発機構の解明
- Live cell imaging in Mutagenesis
- Mutation mechanisms induced by DNA adducts
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Papers (41):
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Weiying Liu, Manabu Yasui, Akira Sassa, Xinyue You, Jingjing Wan, Yiyi Cao, Jing Xi, Xinyu Zhang, Masamitsu Honma, Yang Luan. FTO regulates the DNA damage response via effects on cell-cycle progression. Mutation research. Genetic toxicology and environmental mutagenesis. 2023. 887. 503608-503608
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Masamitsu Honma, Masami Yamada, Manabu Yasui, Katsuyoshi Horibata, Kei-ichi Sugiyama, Kenichi Masumura. In vivo and in vitro mutagenicity of perillaldehyde and cinnamaldehyde. Genes and Environment. 2021. 43. 1
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Akira Sassa, Takayuki Fukuda, Akiko Ukai, Maki Nakamura, Ryosuke Sato, Sho Fujiwara, Kouji Hirota, Shunichi Takeda, Kei-Ichi Sugiyama, Masamitsu Honma, et al. Follow-up genotoxicity assessment of Ames-positive/equivocal chemicals using the improved thymidine kinase gene mutation assay in DNA repair-deficient human TK6 cells. Mutagenesis. 2021
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Toshio Kasamatsu, Airi Kitazawa, Sumie Tajima, Masahiro Kaneko, Kei-Ichi Sugiyama, Masami Yamada, Manabu Yasui, Kenichi Masumura, Katsuyoshi Horibata, Masamitsu Honma. Development of a new quantitative structure-activity relationship model for predicting Ames mutagenicity of food flavor chemicals using StarDropTM auto-ModellerTM. Genes and environment : the official journal of the Japanese Environmental Mutagen Society. 2021. 43. 1. 16-16
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Manabu Yasui, Takayuki Fukuda, Akiko Ukai, Jiro Maniwa, Tadashi Imamura, Tsuneo Hashizume, Haruna Yamamoto, Kaori Shibuya, Kazunori Narumi, Yohei Fujiishi, et al. Weight of evidence approach using a TK gene mutation assay with human TK6 cells for follow-up of positive results in Ames tests: a collaborative study by MMS/JEMS. Genes and environment : the official journal of the Japanese Environmental Mutagen Society. 2021. 43. 1. 7-7
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MISC (40):
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小田切瑞基, 安井学, 本間正充, 杉山圭一, 浦聖恵, 佐々彰. Establishment of an epigenotoxicity assay using the human lymphoblastoid TK6 cell line. 日本環境変異原ゲノム学会大会プログラム・要旨集. 2021. 50th
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竹石歩奈, 古樫浩之, 小田切瑞基, 笹沼博之, 武田俊一, 安井学, 本間正充, 菅澤薫, 浦聖恵, 佐々彰. Tyrosyl-DNA phosphodiesterasesはDNA中のリボヌクレオチドを起因とする突然変異形成に関与する. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
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小林春花, 東條あかり, 佐々彰, 安井学, 本間正充, 浦聖恵. 転写活性領域におけるDNA二本鎖切断修復経路の選択に果たすヒストンメチル化酵素NSD2の役割. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
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小田切瑞基, 安井学, 本田大士, 浦聖恵, 佐々彰. Development of the ”epi-TK assay” for quantitative evaluation of chemical-induced epigenetic changes using human lymphoblastoid TK6 cells. 日本環境変異原学会大会プログラム・要旨集. 2020. 49th (CD-ROM)
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佐々彰, 安井学, 竹石歩奈, 原田佳歩, 鈴木慈, 津田雅貴, 笹沼博之, 武田俊一, 菅澤薫, 本間正充, et al. リボヌクレオチドが誘発する奇異突然変異とその防御機構. 日本遺伝学会大会プログラム・予稿集. 2018. 90th
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Work history (4):
- 2006/04 - - 現職
- 2005/04 - 2006/03 (独)産業技術総合研究所 産総研特別研究員
- 2004/04 - 2005/03 ニューヨーク州立大学医学部NIHポスドクフェロー
- 2003/04 - 2004/03 日本学術振興会特別研究員PD(京都大学地球環境学大学院所属)
Awards (4):
- 2017 - Genes & Environment Best Paper Award
- 2015 - 日本環境変異原学会ベストプレゼンテーション賞
- 2013 - 日本環境変異原学会研究奨励賞
- 2005 - 日本環境変異原学会ベストプレゼンテーション賞
Association Membership(s) (2):
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