Ozoe Yoshihisa

• Design and synthesis of safe insecticides acting on neurotransmitter receptors of insect pests
• Structures/functions of insect neurotransmitter receptors
• Structures and Functions of Insect Neurotransmitter Receptors
• Mode of Action and Structure-Activity Relationships of Compounds Acting at Insect Neurotransmitter Receptors
• 昆虫・線虫の神経伝達物質受容体とイオンチャネルの構造,分子機能,生理学的役割,および薬理学的性質の解明

• Cheng-Wang Sheng, Zhong-Qiang Jia, Yoshihisa Ozoe, Qiu-Tang Huang, Zhao-Jun Han, Chun-Qing Zhao. Molecular cloning, spatiotemporal and functional expression of GABA receptor subunits RDL1 and RDL2 of the rice stem borer Chilo suppressalis. Insect Biochemistry and Molecular Biology. 2018. 94. 18-27
• Miho Asahi, Masaki Kobayashi, Takahiro Kagami, Kunimitsu Nakahira, Yuki Furukawa, Yoshihisa Ozoe. Fluxametamide: A novel isoxazoline insecticide that acts via distinctive antagonism of insect ligand-gated chloride channels. Pesticide Biochemistry and Physiology. 2018. 151. 67-72
• Yunosuke Nakata, Toshinori Fuse, Kohei Yamato, Miho Asahi, Kunimitsu Nakahira, Fumiyo Ozoe, Yoshihisa Ozoe. A Single Amino Acid Substitution in the Third Transmembrane Region Has Opposite Impacts on the Selectivity of the Parasiticides Fluralaner and Ivermectin for Ligand-Gated Chloride Channels. MOLECULAR PHARMACOLOGY. 2017. 92. 5. 546-555
• Tomo Kita, Takeshi Hayashi, Tomohiro Ohtani, Haruka Takao, Hiroshi Takasu, Genyan Liu, Hiroto Ohta, Fumiyo Ozoe, Yoshihisa Ozoe. Amitraz and its metabolite differentially activate alpha- and beta-adrenergic-like octopamine receptors. PEST MANAGEMENT SCIENCE. 2017. 73. 5. 984-990
• Tomo Kita, Takahiro Irie, Kazuki Nomura, Fumiyo Ozoe, Yoshihisa Ozoe. Pharmacological characterization of histamine-gated chloride channels from the housefly Musca domestica. NEUROTOXICOLOGY. 2017. 60. 245-253

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• Genyan Liu, Bente Frolund, Fumiyo Ozoe, Yoshihisa Ozoe. Differential interactions of 5-(4-piperidyl)-3-isoxazolol analogues with insect gamma-aminobutyric acid receptors leading to functional selectivity. INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2015. 66. 64-71
• Genyan Liu, Fumiyo Ozoe, Kenjiro Furuta, Yoshihisa Ozoe. 4,5-Substituted 3-Isoxazolols with Insecticidal Activity Act as Competitive Antagonists of Housefly GABA Receptors. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY. 2015. 63. 28. 6304-6312
• Toshinori Fuse, Izumi Ikeda, Tomo Kita, Shogo Furutani, Hiromitsu Nakajima, Kazuhiko Matsuda, Fumiyo Ozoe, Yoshihisa Ozoe. Synthesis of photoreactive ivermectin B-1a derivatives and their actions on Haemonchus and Bombyx glutamate-gated chloride channels. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY. 2015. 120. 82-90
• Genyan Liu, Kenjiro Furuta, Hiromitsu Nakajima, Fumiyo Ozoe, Yoshihisa Ozoe. Competitive antagonism of insect GABA receptors by 4-substituted 5-(4-piperidyl)-3-isothiazolols. BIOORGANIC & MEDICINAL CHEMISTRY. 2014. 22. 17. 4637-4645
• Mohammad Mostafizur Rahman, Genyan Liu, Kenjiro Furuta, Fumiyo Ozoe, Yoshihisa Ozoe. Synthesis of 1,3-di- and 1,3,4-trisubstituted 1,6-dihydro-6-iminopyridazines as competitive antagonists of insect GABA receptors. JOURNAL OF PESTICIDE SCIENCE. 2014. 39. 3-4. 133-143

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• β-アドレナリン作動性様オクトパミン受容体作用物質のスクリーニング方法
• β-アドレナリン作動性様オクトパミン受容体作用物質のスクリーニング方法
• New Active Substance, Method for Producing the Same and Use
• New Substance PF1223 and Method for Producing the Same

• Advances in Agrochemicals: Ion Channels and G Protein-Coupled Receptors (GPCRs) as Targets for Pest Control Volume 1: Ion Channels and Gap Junctions
  American Chemical Society 2017
• Advances in Agrochemicals: Ion Channels and G Protein-Coupled Receptors (GPCRs) as Targets for Pest Control Volume 2: GPCRs and Ion Channels
  American Chemical Society 2017
• Discovery and Synthesis of Crop Protection Products
  American Chemical Society 2015 ISBN:9780841231023
• Target Receptors in the Control of Insect Pests: Part II
  Academic Press 2014 ISBN:9780124170100
• Target Receptors in the Control of Insect Pests, Part I
  Academic Press 2013

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• γ-BHC骨格にフッ素原子あるいは塩素原子を付加した化合物の殺虫およびGABAアンタゴニスト活性
  (日本農芸化学会2018年大会 2018)
• リガンド作動性Cl-チャネル変異体におけるフルララネルの活性
  (日本農薬学会第43回大会 2018)
• Dieldrin抵抗性イエバエ(OCR系)の非競合的GABAアンタゴニストに対する交差抵抗性
  (日本農薬学会第43回大会 2018)
• γ-およびα-BHC骨格にフッ素原子あるいは塩素原子が付加した化合物のGABAアンタゴニスト活性
  (日本農薬学会第43回大会 2018)
• イエバエグルタミン酸作動性クロライドチャネルの機能解析
  (第13回トランスポーター研究会年会 2018)

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• 1974 - 1976 Kyushu University
• 1970 - 1974 Kyushu University School of Agriculture

• Doctor of Agriculture (Kyushu University)

• 2017 - 現在 Shimane University Faculty of Life and Environmental Science
• 1996 - 2017 Shimane University Faculty of Life and Environmental Science
• 1995 - 1996 Shimane University Faculty of Life and Environmental Science
• 1989 - 1995 Shimane University
• 1976 - 1989 Shimane University

• 2017 - 現在 日本農芸化学会 特別参与
• 1997 - 現在 日本農薬学会 評議員
• 1997 - 2016 日本農芸化学会 支部参与
• 2001 - 2015 日本農薬学会 編集委員会委員

• 2016/09/15 - 日本農芸化学会中四国支部支部功労賞
• 2016/08/22 - ACS International Award for Research in Agrochemicals
• 2004/03/24 - 望月喜多司記念業績賞
• 2004/03/24 - 日本農薬学会賞業績賞
• 2004/03 - Pesticide Science Society of Japan Award (on Proniment Achievement)
1985/03/28 - 日本農薬学会賞奨励賞
1985/03 - Pesticide Science Society of Japan Award (on High Prospectiveness)

アメリカ化学会 ,  日本農芸化学会 ,  日本農薬学会 ,  American Society for Pharmacology and Experimental Therapeutics ,  Society for Neuroscience ,  American Chemical Society ,  Japan Neuroscience Society ,  Japanese Society of Applied Entomology and Zoology ,  Pesticide Science Society of Japan ,  and Agrochemistry ,  Biotechnology ,  Japan Society of Bioscience