Rchr
J-GLOBAL ID:200901009245557057   Update date: Jul. 15, 2024

Horie Syunji

HORIE SYUNJI | Horie Syunji
Affiliation and department:
Job title: Associate Professor
Homepage URL  (1): http://www.p.chiba-u.ac.jp/lab/hinka/index.html
Research field  (5): Physiology ,  Anatomy ,  Clinical pharmacy ,  Pharmacology ,  Pharmaceuticals - health and biochemistry
Research keywords  (15): 薬効解析 ,  和漢薬 ,  呼吸器 ,  消化器 ,  神経薬理学 ,  免疫組織化学 ,  Drug evaluation ,  Natural medicine ,  Herbal medicine ,  Trachea ,  Lung ,  Intestine ,  Stomach ,  Neuropharmacology ,  Immunohistochemistry
Research theme for competitive and other funds  (34):
  • 2022 - 2025 Involvement of neuroimmune in TRP channel-related gut hyperreactivity in animal models of functional gastrointestinal diseases
  • 2018 - 2021 Mechanisms for increase of TRP channels in visceral hypersensitivity in inflammatory and functional bowel disease model animals
  • 2015 - 2018 Role of thermo-sensitive TRPV1 and TRPM8 channels in visceral hypersensitivity in inflammatory bowel disease model animals and ulcerative colitis patients
  • 2014 - 2017 Studies on the synthesis of SPECT probe to elucidate the in vivo dynamics of natural opioids
  • 2012 - 2016 Role of thermo-sensitive TRP channels in stress-induced visceral hyperesthesia: analyses of samples from disease model animals and patients
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Papers (63):
  • Noriyuki Ohashi, Kimihito Tashima, Takao Namiki, Syunji Horie. Allyl isothiocyanate, an activator of TRPA1, increases gastric mucosal blood flow through calcitonin gene-related peptide and adrenomedullin in anesthetized rats. Journal of pharmacological sciences. 2023. 151. 4. 187-194
  • Masatoshi Yoshikubo, Kimihito Tashima, Masaki Raimura, Yuto Watanabe, Yukiko Noma, Syunji Horie. Daikenchuto, a Traditional Kampo Medicine, Facilitates Mucosal Hyperemic Responses through Activation of TRPA1- and TRPV1-Expressing Sensory Nerves in Rat Stomach. Planta Medica International Open. 2022. 9. 01. e72-e79
  • Tashima Kimihito, Oshige Marina, Fujii Yoko, Horie Syunji. Allyl isothiocyanate-induced acute inflammation in the gastric mucosa leads to the impaired gastric motility in rodents: involvement of substance P and calcitonin gene-related peptide, but not mast cells. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2022. 96. 1-B-P-053
  • Kazuki Hashimoto, Kimihito Tashima, Taku Imai, Kenjiro Matsumoto, Syunji Horie. The rodent model of impaired gastric motility induced by allyl isothiocyanate, a pungent ingredient of wasabi, to evaluate therapeutic agents for functional dyspepsia. Journal of Pharmacological Sciences. 2021. 145. 1. 122-129
  • Kenjiro Matsumoto, Hiroki Kawanaka, Masatoshi Hori, Kosuke Kusamori, Daichi Utsumi, Takuya Tsukahara, Kikuko Amagase, Syunji Horie, Akira Yamamoto, Hiroshi Ozaki, et al. Role of transient receptor potential melastatin 2 in surgical inflammation and dysmotility in a mouse model of postoperative ileus. American journal of physiology. Gastrointestinal and liver physiology. 2018. 315. 1. G104-G116
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MISC (161):
  • 趙 春暁, 田嶋 公人, 並木 隆雄, 堀江 俊治. センノシドA誘発慢性結腸通過遅延マウスモデルにおける結腸運動に対する大建中湯の改善作用. 応用薬理. 2021. 100. 5-6. 138-138
  • Megumi Koide, Chisato Tachibana, Tomoharu Shinoki, Kimihito Tashima, Syunji Horie. A NOVEL RAT MODEL OF HEARTBURN RESULTING FROM INCREASED THERMO-SENSITIVE TRPV1 AND TRPM8 CHANNELS-EXPRESSING SENSORY NERVES IN THE LOW ESOPHAGUS BASED ON GASTROESOPHAGEAL REFLUX DISEASE. GASTROENTEROLOGY. 2020. 158. 6. S268-S269
  • Kimihito Tashima, Noriyuki Ohashi, Masatoshi Yoshikubo, Marina Oshige, Takao Namiki, Syunji Horie. ALLYL ISOTHIOCYANATE, AN ACTIVATOR OF TRPA1 CHANNEL, INCREASES GASTRIC MUCOSAL BLOOD FLOW THROUGH TRPV1-EXPRESSING AND NON-EXPRESSING SENSORY NERVES IN RATS: INVOLVEMENT OF CALCITONIN GENE-RELATED PEPTIDE. GASTROENTEROLOGY. 2020. 158. 6. S520-S520
  • 田嶋 公人, 吉久保 匡甫, 内木 蓮, 後藤 友希, 島田 博文, 大重 茉里奈, 並木 隆雄, 堀江 俊治. 消化管疾患に対する漢方薬のエビデンスの構築をめざして 実験動物を用いた大建中湯による胃腸機能の改善作用 温度感受性TRPA1とTRPV1チャネルの関与. 日本消化管学会雑誌. 2020. 4. Suppl. 163-163
  • 田嶋 公人, 後藤 友希, 島田 博文, 並木 隆雄, 堀江 俊治. 摘出マウス結腸における大建中湯による平滑筋収縮作用 TRPチャネルとカルシトニン遺伝子関連ペプチド. 和漢医薬学会学術大会要旨集. 2019. 36回. 96-96
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Patents (6):
  • 血管平滑筋弛緩剤
  • 抗アレルギー剤及び抗アレルギー食品
  • ウコンの抽出エキス及びその医薬用途
  • Vasorelaxant from herbal medicine
  • Curcuma longa as an anti-allergy drug and food
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Books (13):
  • ファーマシューティカルノート
    医学評論社 2003
  • Introduction-The genus Magnolia(jointly worked)
    Medicinal and Aromatic Plants volume 28, Magnolia, Taylor & Francis 2002
  • 胃酸関連疾患の病態と治療(共著)
    医学書院 2000
  • Acid related diseases
    2000
  • 幽門洞潰瘍に対するカプサイシン感受性知覚神経の役割(共著)
    胃粘膜防御機構におけるカプサイシン感受性知覚神経の役割(医薬ジャーナル社) 1999
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Works (8):
  • 消化器及び呼吸器における酸感受性受容体の分布
    2002 -
  • 附子アルカロイドの冷え改善作用の研究
    2000 -
  • Vasorelaxant effect of Aconite alkaloids
    2000 -
  • FKH6遺伝子ノックアウトマウスにおける胃酸分泌不全の解析
    1998 -
  • ラット幽門洞胃潰瘍病態モデルを中心としたカプサイシン感受性神経の機能的役割
    1998 -
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Education (6):
  • - 1988 Chiba University
  • - 1988 Chiba University Graduate School, Division of Pharmaceutical Sciences
  • - 1987 Toyama Medical and Pharmaceutical University
  • - 1987 Toyama Medical and Pharmaceutical University Graduate School, Division of Pharmaceutical Sciences
  • - 1985 Toyama Medical and Pharmaceutical University
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Professional career (1):
  • Ph.D (Chiba University)
Work history (12):
  • 2002 - 2003 Ministry of Education,Culture,Sports,Science and Technology
  • 2000 - 2001 Chiba University Faculty of Pharmaceutical Sciences
  • 2000 - 2001 Ministry of Education and Science,
  • 2000 - 2001 Chiba University, Associate Professor
  • 2001 - - 千葉大学 大学院薬学研究院 助教授
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Committee career (4):
  • 1999 - 和漢医薬学会 評議員
  • 1999 - 日本薬理学会 評議員
  • 1999 - Medical and Pharmaceutical Society of WAKAN-YAKU councilor
  • 1999 - Japanese Pharmacological Society councilor
Association Membership(s) (8):
実験潰瘍学会 ,  和漢医薬学会 ,  日本薬学会 ,  日本薬理学会 ,  Japanese Society of Ulcer Research ,  Medical and Pharmaceutical Society of WAKAN-YAKU ,  Pharmaceutical Society of Japan ,  Japanese Pharmacological Society
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