Hirano Tomoya

ヒラノトモヤ | Hirano Tomoya

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://www.ompu.ac.jp/class/pharm/pmb.html

Research field (2)： Pharmaceuticals - chemistry and drug development , Chemical biology

Research keywords (5)： Caged compound , Epigenetics , Fluorescence , Molecular Imaging , Chemical Biology

Research theme for competitive and other funds (19)：

2021 - 2024 Development of novel methods for the analysis of physiological functions of modified nucleic acids and amino acids based on covalent bond formation
2018 - 2021 Development of novel methods for analysis and treatment of central nervous system based on protective groups controllable with photon and biomolecule
2018 - 2019 強紫外光が照射された部位選択的な治療を可能とする分子システムの開発
2015 - 2018 Development of novel functional molecules that selectively functions under disease-specific microenvironment
2014 - 2017 Development of novel detection method for histone methylation and HMT inhibitors

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Papers (47)：

Takeshi Yamada, Kanoko Yoshida, Takashi Kikuchi, Tomoya Hirano. Isolation and Structure Elucidation of New Cytotoxic Macrolides Halosmysins B and C from the Fungus Halosphaeriaceae sp. Associated with a Marine Alga. Marine drugs. 2022. 20. 4
Saki Takayanagi, Kengo Watanabe, Takeshi Maruyama, Motoyuki Ogawa, Kazuhiro Morishita, Mayumi Soga, Tomohisa Hatta, Tohru Natsume, Tomoya Hirano, Hiroyuki Kagechika, et al. ASKA technology-based pull-down method reveals a suppressive effect of ASK1 on the inflammatory NOD-RIPK2 pathway in brown adipocytes. Scientific reports. 2021. 11. 1. 22009-22009
Daiki Kato, Takuya Shiraishi, Hiroyuki Kagechika, Tomoya Hirano. 6-Arylcoumarin as a Scaffold of Photofunctional Molecules with OFF-ON-OFF Type Regulation. The Journal of Organic Chemistry. 2021. 86. 3. 2264-2270
Hiroyuki Kagechika, Shinya Fujii, Ryota Sekine, Atsushi Kano, Hiroyuki Masuno, Emiko Kawachi, Tomoya Hirano. Synthesis and Structure-Activity Relationship Study of 1,12-Dicarba-closo-dodecaborane-based Triol Derivatives as Nonsecosteroidal Vitamin D Analogs. HETEROCYCLES. 2021. 103. 1. 444-444
Takeshi Yamada, Haruka Kogure, Minami Kataoka, Takashi Kikuchi, Tomoya Hirano. Halosmysin A, a Novel 14-Membered Macrodiolide Isolated from the Marine-Algae-Derived Fungus Halosphaeriaceae sp. Marine Drugs. 2020. 18. 6. 320-320

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MISC (13)：

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Patents (10)：

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Books (6)：

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Lectures and oral presentations (60)：

活性酸素存在下で機能する光分解性保護基の開発
(日本薬学会第141年会 2021)
OFF-ON-OFF型制御により特定のpH領域選択的に機能するCaged化合物の開発
(第42回日本光医学・光生物学会 2021)
OFF-ON-OFF型制御により特定のpH領域で機能するCaged化合物の開発
(第70回日本薬学会関西支部大会 2020)
N1-メチルアデノシンを検出する有機化学反応の開発
(第64回日本薬学会関東支部大会 2020)
特定のpH領域選択的に機能する光分解性保護基の開発
(第64回日本薬学会関東支部大会 2020)

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Education (3)：

1999 - 2002 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
1997 - 1999 The University of Tokyo Graduate School, Division of Pharmaceutical Sciences
1993 - 1997 The University of Tokyo Faculty of Pharmaceutical Science

Professional career (1)：

Work history (6)：

2021/04 - 現在 Osaka Medical and Pharmaceutical University Faculty of Pharmacy Professor
2019/04 - 2021/03 Osaka University of Pharmaceutical Sciences Department of Medicinal Chemistry Professor
2009/03 - 2019/03 Tokyo Medical and Dental University Institute of Biomaterials and Bioengineering Biomolecular Chemistry Organic and Medicinal Chemistry Associate Professor
2004/09/01 - 2009/02/28 Tokyo Medical and Dental University Biomedical Science PhD Program / Graduate School of Biomedical Science Assistant Professor
2003/07/15 - 2004/08/31 University of California San Francisco Visiting Postdoctoral Scholar

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Committee career (9)：

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Awards (1)：

Association Membership(s) (5)：

日本レチノイド研究会 , 日本光医学・光生物学会 , 日本ケミカルバイオロジー学会 , 日本化学会 , 日本薬学会

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