Miyazaki Hiroaki

ミヤザキヒロアキ | Miyazaki Hiroaki

Affiliation and department：
Job title： Professor

Research field (2)： Clinical pharmacy , Physiology

Research keywords (7)： osmoregulation , epithelial transport , cell biology , 細胞増殖 , 浸透圧調整 , 上皮輸送 , 細胞生物学

Research theme for competitive and other funds (19)：

2015 - 2018 A targeting mechanism of membrane protein to proteasome
2016 - 2018 癌細胞のクロライドシフトによる細胞接着能変化を介したがん転移メカニズムの解明
2014 - 2017 Sensing, processing and neurotransmission of taste in the taste buds
2013 - 2015 Continuous pH measurement of interstitial fluid and clarification of pathogenic mechanism of insulin resistance by ISFET pH sensor
2012 - 2015 Inhibitory mechanism of quercetin on ENaC in salt-sensitive hypertension

Show all

Papers (54)：

Junichi Sato, Koya Nakano, Hiroaki Miyazaki. Decreased intracellular chloride enhances cell migration and invasion via activation of the ERK1/2 signaling pathway in DU145 human prostate carcinoma cells. Biochemical and Biophysical Research Communications. 2023. 149170-149170
Shigekuni Hosogi, Atsukazu KUWAHARA, Yuko KUWAHARA, Saori TANAKA, Chikao SHIMAMOTO, Noriko TAGAWA, Ikuo KATO, Kanji YOSHIMOTO, Wataru AOI, Kazuyuki TAKATA, et al. Mumefural prevents insulin resistance and amyloid-beta accumulation in the brain by improving lowered interstitial fluid pH in type 2 diabetes mellitus. Biomedical Research. 2023. 44. 1. 17-29
Zhongming Ma, Akiyuki Taruno, Makoto Ohmoto, Masafumi Jyotaki, Jason C Lim, Hiroaki Miyazaki, Naomi Niisato, Yoshinori Marunaka, Robert J Lee, Henry Hoff, et al. CALHM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes. Neuron. 2018. 98. 3. 547-561
Yoshinori Marunaka, Naomi Niisato, Hiroaki Miyazaki, Ken-Ichi Nakajima, Akiyuki Taruno, Hongxin Sun, Rie Marunaka, Motoki Okui, Toshiro Yamamoto, Narisato Kanamura, et al. Quercetin is a Useful Medicinal Compound Showing Various Actions Including Control of Blood Pressure, Neurite Elongation and Epithelial Ion Transport. Current medicinal chemistry. 2018. 25. 37. 4876-4887
Sachie Tanaka, Hiroaki Miyazaki, Atsushi Shiozaki, Daisuke Ichikawa, Eigo Otsuji, Yoshinori Marunaka. Cytosolic Cl-Affects the Anticancer Activity of Paclitaxel in the Gastric Cancer Cell Line, MKN28 Cell. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY. 2017. 42. 1. 68-80

ｍore...

MISC (20)：

宮崎裕明. 細胞内クロライドイオンによる癌細胞機能制御メカニズム. 京都府立医科大学雑誌. 2018. 127. 3. 127-135
宮崎裕明, 中島謙一, 丸中良典. 細胞内クロライドイオンによる神経突起伸長・膜形成制御メカニズムの解明. 膜. 2015. 40. 5. 266-271
Hiroaki Miyazaki, Naomi Niisato, Yoshinori Marunaka. Oscillatory changes in the activity of Na+/K+/2Cl(-) co-transporter control cell cycle progression via changes in the intracellular concentration of Cl- in MKN28 human gastric cancer cells. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S200-S200
Shigekuni Hosogi, Yoshinori Marunaka, Naomi Niisato, Katsuyuki Kusuzaki, Hiroaki Miyazaki. Cl- channels/transporters as new targets for cancer therapies based on disruption of autophagy ability via modification of lysosome acidification. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S139-S139
Hiroaki Miyazaki, Kevin Strange. Differential regulation of CLC anion channel by SPAK kinase ortholog mediated multisite phosphorylation. FASEB JOURNAL. 2012. 26

ｍore...

Books (2)：

からだと水の事典
2008
水とアクアポリンの生物学
2008

Lectures and oral presentations (57)：

Effect of Na+-K+-2Cl- cotranspoter (NKCC) expression level on Cl- sensitivity of cell proliferation in human esophageal squamous carcinoma cell line KYSE70
(The Annual Meeting of The Physiological Society of Japan 2024)
Effect of changes in intracellular Cl- concentration on the activity of small G protein Ras in the human prostate cancer cell line DU145.
(The Annual Meeting of The Physiological Society of Japan 2024)
Measurement of activity of Na+-K+-2Cl- cotransporter in human breast cancer cell line MCF-7
(The Annual Meeting of The Physiological Society of Japan 2024)
Effect of reduced intracellular Cl- concentration on cell proliferation in a human breast cancer cell line, MDA-MB231 cells
(The Annual Meeting of The Physiological Society of Japan 2024)
Reduced intracellular Cl- concentration promotes cell migration and invasion via activation of the Ras-ERK signaling pathway and facilitation of matrix metalloproteinase-1 (MMP-1) expression in DU145 cells
(The Annual Meeting of The Physiological Society of Japan 2024)

ｍore...

Education (3)：

1996 - 1999 東京大学大学院理学系研究科生物科学専攻博士課程
1994 - 1996 東京大学大学院理学系研究科生物科学専攻修士課程
1990 - 1994 Yokohama City University

Professional career (1)：

Doctor(Science) (The University of Tokyo)

Work history (8)：

2018/04 - 現在 Setsunan University Faculty of Science and Engineering, Department of Life Science
2015/12 - 2018/03 Kyoto Prefectural University of Medicine Graduate School of Medical Science
2012/09 - 2015/11 Kyoto Prefectural University of Medicine Graduate School of Medical Science
2007/04 - 2012/08 Kyoto Prefectural University of Medicine Graduate School of Medical Science
2010/04 - 2012/03 Mount Desert Island Biological Laboratory Postdoctoral Fellow

Show all

Committee career (1)：

2006/04 - 現在日本生理学会評議員

Awards (3)：

2013/03 - 日本生理学会第90回日本生理学会大会佐川喜一賞
2012/11 - The 3rd Symposium of the International Society for Proton Dynamics in Cancer The Outstanding Presentation Award
2000 - Zoological Science Award

Association Membership(s) (3)：

THE MEMBRANE SOCIETY OF JAPAN , The Molecular Biology Society of Japan , The Physiological Society of Japan

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page