Rchr
J-GLOBAL ID：200901011482301215   Update date: Feb. 14, 2024

Yokoi Tsuyoshi

Yokoi Tsuyoshi
Homepage URL  (1)： http://www.med.nagoya-u.ac.jp/toxicogenomics/index.html
Research field  (1)： Pharmaceuticals - health and biochemistry
Research keywords  (5)： pre-clinical drug discovery ,  drug development ,  toxicology ,  drug safety ,  drug metabolism
Research theme for competitive and other funds  (29)：
  • 2019 - 2022 特異体質性薬物性肝障害発症の個体差の決定因子の解明と予測試験系の開発
  • 2019 - 2021 Comprehensive functional analysis of lncRNAs in liver fibrosis
  • 2016 - 2019 Establishment of a predictive test system for idiosyncratic drug-induced liver injury and study for evaluation of onset biomarkers
  • 2015 - 2017 Factors of individual variability in onset of drug-induced liver injury
  • 2013 - 2016 Risk assessment and mechanistic analysis of adverse reactions of the acyl glucuronides.
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Papers (384)：
  • Shingo Oda, Yuka Hirabuki, Taiki Takeuchi, Takumi Kagawa, Tsuyoshi Yokoi. Plasma miR-218a-5p as a biomarker for acute cholestatic liver injury in rats and investigation of its pathophysiological roles. Journal of applied toxicology : JAT. 2021. 41. 10. 1537-1552
  • Tatsuki Fukami, Tsuyoshi Yokoi, Miki Nakajima. Non-P450 Drug-Metabolizing Enzymes: Contribution to Drug Disposition, Toxicity, and Development. Annual review of pharmacology and toxicology. 2021
  • Kosuke Yoshida, Akira Yokoi, Mai Sugiyama, Shingo Oda, Kazuhisa Kitami, Satoshi Tamauchi, Yoshiki Ikeda, Nobuhisa Yoshikawa, Kimihiro Nishino, Kaoru Niimi, et al. Expression of the chrXq27.3 miRNA cluster in recurrent ovarian clear cell carcinoma and its impact on cisplatin resistance. Oncogene. 2021. 40. 7. 1255-1268
  • Reo Kawata, Shingo Oda, Yoshihiro Koya, Hiroaki Kajiyama, Tsuyoshi Yokoi. Macrophage-derived extracellular vesicles regulate concanavalin A-induced hepatitis by suppressing macrophage cytokine production. Toxicology. 2020. 443. 152544-152544
  • Reo Kawata, Takumi Kagawa, Yoshihiro Koya, Hiroaki Kajiyama, Shingo Oda, Tsuyoshi Yokoi. Exploration of small RNA biomarkers for testicular injury in the serum exosomes of rats. Toxicology. 2020. 440. 152490-152490
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MISC (123)：
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Education (2)：
  • 1978 - 1980 Gifu Pharmaceutical University Graduate School, Division of Pharmaceutical Sciences
  • 1974 - 1978 Gifu Pharmaceutical University Faculty of Pharmaceutical Science
Professional career (2)：
  • 医学博士 (東北大学)
  • 薬学博士 (岐阜薬科大学)
Work history (6)：
  • 2013/05/01 - 現在 Nagoya University Graduate School of Medicine
  • 1997/04/01 - 2013/04/30 Kanazawa University Faculty of Pharmaceutical Sciences
  • 1990/05/01 - 1997/03/31 Hokkaido University Faculty of Pharmaceutical Sciences
  • 1989/01/01 - 1990/04/30 Tohoku University Faculty of Medicine
  • 1984/01/01 - 1988/12/31 Tohoku University Faculty of Medicine
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Committee career (12)：
  • 2013/10/01 - 現在 Toxicology Research Advisory Board
  • 2013/10/01 - 現在 岐阜薬科大学 客員教授 客員教授
  • 2013/05/01 - 現在 金沢大学医学部 非常勤講師 非常勤講師
  • 2012/10/01 - 現在 Biopharmaceutics and Drug Dispositio Editorial Board
  • 2012/04/01 - 現在 Journal of Toxicological Sciences Editorial Board
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Association Membership(s) (12)：
日本医療薬学会 ,  日本生化学会 ,  日本薬学会 ,  American Association of Pharmaceutical Scientists ,  American Society for Pharmacology and Experimental Therapeutics ,  ISSX (Internatinal Sciety for the Study of Xenobiotics) ,  Society of Toxicology, USA ,  HAB 研究協議会学会 ,  日本実験動物代替法学会 ,  日本薬理学会 ,  日本薬物動態学会 ,  日本毒性学会
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