Rchr
J-GLOBAL ID:200901013456365143
Update date: Oct. 08, 2024
AOKI Ichio
AOKI Ichio
Affiliation and department:
Job title:
Senior Investigator
Homepage URL (1):
https://www.iaoki.jp/
Research keywords (5):
In vivo imaging
, Neuroscience
, Nanomedicine
, Nuclear Magnetic Resonance in Medicine
, Molecular Imaging
Research theme for competitive and other funds (41):
- 2021 - 2027 国際共同研究による超高磁場MRIを用いた病理細胞診断の実現
- 2021 - 2026 低侵襲性の反応性ナノ・マンガン造影剤開発による「MRI病理組織変性解析法」の創成
- 2017 - 2022 Manganese Staining-MRI Pathological Analysis
- 2018 - 2020 量子ドットによる新規セラノスティックナノ粒子の開発
- 2016 - 2019 Pathophysiology of glutamate excitotoxicity evaluated with MR spectroscopy
- 2015 - 2019 Visualization of cell membrane water permeability for in vivo MRI
- 2014 - 2019 Development of imaging-based diagnostic procedures for brain protein aging
- 2016 - 2018 Development of a microscopic and multiple imaging technology to evaluate 3-dimensional thick living tissues based on magnetic resonance imaging techniques
- 2015 - 2018 Design of functional ligand molecules focused on specific metabolism of cancer cells and their applications for diagnosis and therapy
- 2015 - 2018 Contribution of neuronal stem cells in the subventricular zone to sulcogyrogenesis in the ferret cerebral cortex
- 2015 - 2018 Challenge for artificial hibernation for long-term space flight
- 2015 - 2017 MRI-based PathoView
- 2014 - 2017 Infection control based on photodynamic effect and new treatment for pressure ulcer by promoting wound healing
- 2012 - 2017 Development and application of cell viability imaging using MEMRI
- 2013 - 2016 Development of neuroimaging-based, translatable biomarkers applicable to both human and mouse
- 2012 - 2016 Neurochemistry of mouse model investigated with 7T MR spectroscopy
- 2014 - 2016 合目的機能の統合によるオールインワンナノメディシンの開発と非侵襲がん治療への展開
- 2012 - 2015 Basic study of a bionanodevice for medical application and expansion for its use.
- 2012 - 2015 Development of imaging probe to detect lipid derived radicals from whole body to cells
- 2011 - 2014 Development of on-demand multifunctional delivery systems using dendron lipid assemblies
- 2011 - 2012 Development of MR imaging technology and cell labeling contrast agents for tracking the biokinetics of dendritic cells.
- 2009 - 2011 Research of environmental factors for critical learning periods of empathy in quantitative models of animal refined psychology
- 2009 - 2011 Development of high-performance nano-carrier for next generation medicine
- 2009 - 2011 Signal source of functional MRI under heavy diffusion weighting
- 2009 - 2011 Development and in-vivo application of functional manganese-enhanced MR molecular imaging
- 2009 - 2011 Originally Synthesized Oxy-Redox Sensitive Contrast Substances for in vivo Mapping of Tissue Redox and Oxidant Status in Cancer Using High Field MRI
- 2009 - 2011 In vivo tissue characterization for normal and disease models using diffusion spectral imaging
- 2008 - 2010 Nanobioprobes for Multimodal Imaging Diagnostics of Cancer in Experimental Animals
- 2008 - 2010 Analyses of the mechanisms of resistance to monoclonal antibody therapy and exploration of overcoming strategies.
- 2007 - 2008 Development of Cellular and Molecular Magnetic Resonance Imaging and Application using targeted multimodal probes.
- 2007 - 2008 Development of neurogenesis imaging-visualization of endogeneous neural stem cell
- 2005 - 2008 Development and a medical assessment of the image measurement technique by the 7T400mm grade ultrahigh magnetic field MRI
- 2006 - 2007 IMAGING OF NEUROREGENERATION PROCESS USING MOLECULAR MR IMAGING
- 2005 - 2006 Functional connectivity MRI for the aging brain.
- 2004 - 2005 IMAGING OF NEUROREGENERATION PROCESS USING NEURO-PHARMACOLOGICAL MRI
- 2004 - 2005 脳神経賦活マンガン造影法による機能モジュール再生過程の画像化および評価法の開発
- 2003 - 2004 The development and a clinical application of new imaging technique for epileptic focus using DAIM and tensor MRL
- 2002 - 2003 EVALUATION OF NEURONAL REGENERATION USING MANGANESE ENHANCED AND INCOHERENT MRI
- 2002 - 2003 脳神経賦活マンガン造影法による脳機能モジュールの三次元磁気共鳴画像解析
- 2001 - 2001 脳神経賦活マンガン造影法による脳機能モジュールの3次元磁気共鳴画像解析
- 1999 - 2000 ANALYSIS OF NEUROLOGICAL DISORDERS USING THREE DIMENSIONAL SPIRAL SCAN FUNCTIONAL BRAIN MAPPING
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Papers (227):
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Kohei Ohama, Miku Komiya, Takumi Yamatoya, Ryota Sawamura, Ryunosuke Karashimada, Shan Gao, Yoshikazu Ozawa, Kensuke Osada, Ichio Aoki, Takeshi Nagasaki, et al. Albumin nanoparticle electrostatically loaded with highly anionic Gd-thiacalixarene complex for MRI-guided neutron capture therapy. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2024. 134579-134579
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Shang Wei Li, Ming Feng Hsieh, Taehun Hong, Pengwen Chen, Kensuke Osada, Xueying Liu, Ichio Aoki, Jiashing Yu, Kevin C.W. Wu, Horacio Cabral. Block Copolymer-Stabilized Metal-Organic Framework Hybrids Loading Pd Nanoparticles Enable Tumor Remission Through Near-Infrared Photothermal Therapy. Advanced NanoBiomed Research. 2024. 4. 1
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Akira Sumiyoshi, Sayaka Shibata, Dessislava Lazarova, Zhivko Zhelev, Ichio Aoki, Rumiana Bakalova. Tolerable treatment of glioblastoma with redox-cycling 'mitocans': a comparative study in vivo. Redox report : communications in free radical research. 2023. 28. 1. 2220531-2220531
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Shan Gao, Yutaka Miura, Akira Sumiyoshi, Satoshi Ohno, Keisuke Ogata, Takahiro Nomoto, Makoto Matsui, Yuto Honda, Minoru Suzuki, Megumi Iiyama, et al. Self-Folding Macromolecular Drug Carrier for Cancer Imaging and Therapy. Advanced Science. 2023
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Rumiana Bakalova, Dessislava Lazarova, Akira Sumiyoshi, Sayaka Shibata, Zhivko Zhelev, Biliana Nikolova, Severina Semkova, Tatyana Vlaykova, Ichio Aoki, Tatsuya Higashi. Redox-Cycling "Mitocans" as Effective New Developments in Anticancer Therapy. International journal of molecular sciences. 2023. 24. 9
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MISC (99):
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Yuji Tanimoto, Tomoteru Yamasaki, Narihito Nagoshi, Yuichiro Nishiyama, Satoshi Nori, Soraya Nishimura, Tsuyoshi Iida, Masahiro Ozaki, Osahiko Tsuji, Bin Ji, et al. In vivo monitoring of remnant undifferentiated neural cells following human iPS cell-derived neural stem/progenitor cells transplantation. Stem cells translational medicine. 2020
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高堂裕平, 佐藤英明, 豊田早紀子, 安居昌子, 湊原圭一郎, 田桑弘之, 漆畑拓弥, 高橋真奈美, 下條雅文, 小野麻衣子, et al. タウオパチーモデルマウスにおけるアミノ酸組成物摂取による神経変性抑止効果. Dementia Japan. 2020. 34. 4
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Rumiana Bakalova, Zhivko Zhelev, Thomas Miller, Ichio Aoki, Tatsuya Higashi. Vitamin C versus Cancer: Ascorbic Acid Radical and Impairment of Mitochondrial Respiration?. Oxidative Medicine and Cellular Longevity. 2020. 2020
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Rumiana Bakalova, Zhivko Zhelev, Thomas Miller, Ichio Aoki, Tatsuya Higashi. New potential biomarker for stratification of patients for pharmacological vitamin C in adjuvant settings of cancer therapy. Redox Biology. 2020. 28
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近藤 洋平, 坂本 大地, 野中 洋, 高草木 洋一, 山本 和俊, Murali C Krishna, 青木 伊知男, 山東 信介. 生体内 β-ガラクトシダーゼ活性検出に向けた高感度-核磁気共鳴分子プローブの検討. 第 14 回 日本分子イメージング学会総会・学術集会. 2019
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Patents (8):
Association Membership(s) (5):
日本DDS学会
, Society for Molecular Imaging
, 日本分子イメージング学会
, International Society of Magnetic Resonance in Medicine
, 日本磁気共鳴医学会
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