Research field (2)：
Applied physics - general
, Internal medicine - General
Research theme for competitive and other funds (39)：
2023 - 2027 Evaluation of disordered excitation coordination underlying gut hypersensitivity by functional micro-image analysis
2022 - 2025 スマートナーシングシステムに導入する排便予測指標となる腸電位パターンの探索
2022 - 2024 平滑筋含有臓器にわたる興奮・収縮機構の特殊性普遍性の解明
2019 - 2022 Visualization of micro-coordination in the GI tract reflecting irritability and inflammatory reactions: Elucidation of pathological conditions and development of treatment strategy
2014 - 2017 The investigation into the novel smooth muscle contraction-relaxation mechanism of lower urinary tract and its clinical application
2012 - 2015 Development of highly sensitive magnetic field sensing system for the purpose of cell tissue functional evaluation
2012 - 2015 Fibroblasts and related cells in gastrointestinal tract
2011 - 2013 The basic research for the novel treatment for under active bladder -focusing on the construction of troponin system in smooth muscle-
2011 - 2012 Development of contact less brain wave monitoring device using highly sensitiveMI sensor and its application for medical diagnosis
2011 - 2012 Development of new technology for the analysis of and pharmacological effects on intracellular and intercellular conduction, using pulse-driven MI sensor operated at room temperature
2010 - 2012 Analysis of microRNA function on heart and smooth muscles and itsanti-tumor effect using genetically modified mice
2010 - 2012 The morphological and physiological investigation into the interstitial cells of human and guinea-pig urinary bladder.
2008 - 2010 Investigation of signal correlation and integration in ICC pacemaking
2008 - 2010 The investigation into the molecular and electrophysiological properties of overactive bladder and the research for the novel consequent treatment
2006 - 2008 Regulation of intracellular magnesium concentration
2005 - 2006 Forming control mechanism on pacemaker in the gut differentiated from embryonic stem cells.
2005 - 2006 気道炎症における粘液線毛輸送障害の標的分子とその制御に関する研究
2005 - 2006 チロシン燐酸化修飾を介したL型Caチャネル第二の開口状態調節と機能分化
2004 - 2005 胚性幹細胞からつくる腸管に壁内神経系をつくる
2003 - 2005 Diversity and Similarity of Pacemakers in Peripheral Autonomic Nervous System
2003 - 2004 Investigation of interstitial cells of Cajal and pacemaker mechanism of the gastrointestinal tract using new culture system
2002 - 2004 Identification of magnesium transporter molecules and functional analysis with high temporal/spatial resolution.
2001 - 2002 Cell biology of interstitial cells of Cajal as pacemakers in the gastrointestinal tract
2001 - 2002 Molecular Basis of Multiple Open States in Smooth Muscle Calcium Channels and Related Intracellular Signalling
1999 - 2000 Voltage-dependent modulation of calcium channel kinetics and its contribution to physiological functions
1998 - 2000 Development of a total fluorescence collecting-two photon laser scanning microscope and analysis of intracellular Ca^<2+> dynamics
1997 - 1997 Physiological Relevance of Intracellular Magnesium
1996 - 1997 Investigation into the long channel opening mechanism of the smooth muscle calcium channels
1994 - 1995 Some properties of inward currents and spontaneous excitation of the cell membrane in smooth muscle
1993 - 1994 Analysis of mechanism underlying spontaneity in smooth muscle
1990 - 1992 Effects of intracellular pH on exitability of smooth muscle
1990 - 1990 平滑筋における細胞内Mgイオン濃度の調節とその興奮収縮機構へ与える影響
1989 - 1990 Studies on Physiological Roles of Protein Phosphatases in Mammalian Smooth Muscle Tissues
1989 - 1989 平滑筋における細胞内ホスホモノエステルの生理学的役割の解明
1986 - 1988 Electrophysiological studies on single ionic channels in smooth muscle cell membrane.
Show all
Papers (90)：
Koichiro Yoshimaru, Takayoshi Yamaza, Shunichi Kajioka, Soichiro Sonoda, Yusuke Yanagi, Toshiharu Matsuura, Junko Yoshizumi, Yoshinao Oda, Naoko Iwata, Chiho Takai, et al. Dental pulp stem cells as a therapy for congenital entero-neuropathy. Scientific Reports. 2022. 12. 1
Chiho Takai, Naoko Iwata, Kazunori Kanemaru, Kenji F. Tanaka, Yao Yu, Satoshi Iino, Shinsuke Nakayama. Ratio-metric measurement of intracellular calcium in visceral muscles via selective expression of a yellow cameleon calcium sensor. Sensors and Actuators B: Chemical. 2022. 364
Naoko Iwata, Chiho Takai, Naoto Mochizuki, Mariko Yamauchi, Noriyuki Kaji, Yoshiyuki Kasahara, Shinsuke Nakayama. Classification of Pacemaker Dynamics in the Mouse Intestine by Field Potential Microimaging. 2021
Takanori Saeki, Taisuke Kimura, Keigo Hashidume, Takashi Murayama, Hisao Yamamura, Susumu Ohya, Yoshiaki Suzuki, Shinsuke Nakayama, Yuji Imaizumi. Conversion of Ca2+ oscillation into propagative electrical signals by Ca2+-activated ion channels and connexin as a reconstituted Ca2+ clock model for the pacemaker activity. Biochemical and Biophysical Research Communications. 2019. 510. 2. 242-247
N. Kaji, S. Nakayama, K. Horiguchi, S. Iino, H. Ozaki, M. Hori. Disruption of the pacemaker activity of interstitial cells of Cajal via nitric oxide contributes to postoperative ileus. Neurogastroenterology and Motility. 2018. 30. 8
