Kobayashi Takashi

コバヤシタカシ | Kobayashi Takashi

Affiliation and department：
Job title： Research Assistant

Research field (3)： Functional biochemistry , Developmental biology , Cell biology

Research keywords (11)：細胞分化 , シグナル伝達 , 幹細胞 , 糖代謝 , コンドロイチン硫酸 , ヘパラン硫酸 , ヒアルロン酸 , グリコサミノグリカン , 細胞生物学 , 糖鎖生物学 , プロテオグリカン

Research theme for competitive and other funds (3)：

2022 - 2025 へパラン硫酸の糖鎖構造:iPS細胞分化シグナルの選択的制御
2017 - 2019 Elucidation of mechanism of oxidative stress resistance via metabolic reprogramming of hexosamine biosynthetic pathway in cancer stem cells
2007 - 2008 ヘパラン硫酸3-O-硫酸基によるアンチトロンビンの機能調節

Papers (17)：

Takashi Kobayashi, Akihiro Yamashita, Noriyuki Tsumaki, Hideto Watanabe. Subpopulations of fibroblasts derived from human iPS cells. Communications Biology. 2024. 7. 1. 736
Shungo Iwamoto, Takashi Kobayashi, Hisatoshi Hanamatsu, Ikuko Yokota, Yukiko Teranishi, Akiho Iwamoto, Miyu Kitagawa, Sawako Ashida, Ayane Sakurai, Suguru Matsuo, et al. Tolerable glycometabolic stress boosts cancer cell resilience through altered N-glycosylation and Notch signaling activation. Cell Death & Disease. 2024
Kai Kudo, Takashi Kobayashi, Kosuke Kasai, Hiroyuki Nozaka, Toshiya Nakamura. Chondroitin sulfate is not digested at all in the mouse small intestine but may suppress interleukin 6 expression induced by tumor necrosis factor-α. Biochemical and Biophysical Research Communications. 2023. 642. 185-191
Kosuke Kasai, Yoshiyuki Kuroda, Yutaro Takabuchi, Akihide Nitta, Takashi Kobayashi, Hiroyuki Nozaka, Tomisato Miura, Toshiya Nakamura. Phosphorylation of Thr328 in hyaluronan synthase 2 is essential for hyaluronan synthesis. Biochemical and Biophysical Research Communications. 2020. 533. 4. 732-738
Chatchadawalai Chokchaitaweesuk, Takashi Kobayashi, Tomomi Izumikawa, Naoki Itano. Enhanced hexosamine metabolism drives metabolic and signaling networks involving hyaluronan production and O-GlcNAcylation to exacerbate breast cancer. Cell Death & Disease. 2019. 10. 11. 803

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MISC (4)：

Patents (2)：

Books (4)：

Glycoscience Protocols (GlycoPODv2)
In: Nishihara S, Angata K, Aoki-Kinoshita KF, et al., editors. Glycoscience Protocols (GlycoPODv2) [Internet]. Saitama (JP): Japan Consortium for Glycobiology and Glycotechnology; 2021-. 2021
糖鎖の新機能開発・応用ハンドブック
(株)エヌ・ティー・エス 2015
Progress in Molecular Biology and Translational Science, Vol.93C, Glycosaminoglycans in Development, Health and Disease
Academic Press 2010
実験医学増刊波及・深化する糖鎖研究
羊土社 2007

Lectures and oral presentations (35)：

線維芽細胞の亜分類:ヒトiPS細胞由来線維芽細胞の解析
(第55回日本結合組織学会学術大会 2023)
ヘキソサミン代謝によるがん幹細胞性の制御:ヒアルロン酸とO-GlcNAcシグナルの意義
(第52回日本結合組織学会学術大会 2020)
ヒアルロン酸合成に伴うがんの悪性化とヘキソサミン合成経路の代謝流束およびO-GlcNAc修飾の亢進
(第92回日本生化学会大会 2019)
サケプロテオグリカンを基質としたザイモグラフィー法の開発
(第15回臨床糖鎖研究会 2019)
サケ鼻軟骨プロテオグリカンを使ったコンドロイチン硫酸分解酵素の検出
(日本生化学会大会プログラム・講演要旨集 2018)

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Education (3)：

1999 - 2003 Kanazawa University Graduate School of Natural Science and Technology Division of Life Sciences
1997 - 1999 Kanazawa University Graduate School of Natural Science and Technology
1993 - 1997 Kanazawa University Faculty of Science Department of Biology

Work history (6)：

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Committee career (2)：

2021/09 - 2023/08 日本生化学会中部支部幹事
2019/09 - 2019/09 Proteoglycans Future Leaders Symposium 2019 Organizing Committee

Awards (1)：

2003 - 公益財団法人加藤記念バイオサイエンス振興財団第15回加藤記念国際交流助成 Caspase-like Activity in Programmed Nuclear Death during Conjugation of Tetrahymena thermophila

Association Membership(s) (3)：

日本結合組織学会 , THE JAPANESE SOCIETY OF CARBOHYDRATE RESEARCH , THE JAPANESE BIOCHEMICAL SOCIETY

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