Yagita Hideo

ヤギタヒデオ | Yagita Hideo

Affiliation and department：

Research field (10)： Tumor diagnostics and therapeutics , Hematology and oncology , Gastroenterology , Pharmacology , Infectious disease , Allergies and connective tissue disease , Respiratory medicine , Experimental pathology , Neurosurgery , Immunology

Research keywords (32)：アポトーシス , パーフォリン , Fas , FasL , NK細胞 , CD2 , モノクローナル抗体 , CD27 , TWEAK , TRAIL , GVHD , キラーT細胞 , CD28 , CD80 , CD48 , 自己免疫疾患 , T細胞活性化 , 接着分子 , OX40 , CD86 , DR5 , CD40 , 移植 , LFA-1 , CD70 , Fasリガンド , ICAM-1 , NK , B細胞 , T細胞 , 免疫学 , Immunology

Research theme for competitive and other funds (22)：

2014 - 2016 Establishment of immuno-stimulatory antibody therapy against cancer
2010 - 2012 Development of immuno-stimulatory antibody therapy against cancer
2005 - 2009 Molecular mechanism of cancer immunosurveillance and its application to cancer therapy
2002 - 2004 Physiological and pathological functions of TNF/TNF receptor family molecules.
2001 - 2004 Molecular mechanisms for tumor recognition and destruction by NK cells.

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Papers (1,042)：

Shin Murai, Yoshifumi Yamaguchi, Yoshitaka Shirasaki, Mai Yamagishi, Ryodai Shindo, Joanne M. Hildebrand, Ryosuke Miura, Osamu Nakabayashi, Mamoru Totsuka, Taichiro Tomida, et al. A FRET biosensor for necroptosis uncovers two different modes of the release of DAMPs. Nature Communications. 2018. 9. 1
Kim Terresa, Kim Sol, Song Minju, Lee Cindy, Yagita Hideo, Williams Drake W, Sung Eric C, Hong Christine, Shin Ki-Hyuk, Kang Mo K, et al. Removal of Pre-Existing Periodontal Inflammatory Condition before Tooth Extraction Ameliorates Medication-Related Osteonecrosis of the Jaw-Like Lesion in Mice. AMERICAN JOURNAL OF PATHOLOGY. 2018. 188. 10. 2318-2327
Gotot Janine, Dhana Ermanila, Yagita Hideo, Kaiser Romina, Ludwig-Portugall Isis, Kurts Christian. Antigen-specific Helios(-), Neuropilin-1(-) Tregs induce apoptosis of autoreactive B cells via PD-L1. IMMUNOLOGY AND CELL BIOLOGY. 2018. 96. 8. 852-862
Brennan Amelia J, Law Ruby H. P, Conroy Paul J, Noori Tahereh, Lukoyanova Natalya, Saibil Helen, Yagita Hideo, Ciccone Annette, Verschoor Sandra, Whisstock James C, et al. Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin. CELL DEATH AND DIFFERENTIATION. 2018. 25. 8. 1517-1529
Dufresne Sebastien S, Boulanger-Piette Antoine, Bosse Sabrina, Argaw Anteneh, Hamoudi Dounia, Marcadet Laetitia, Gamu Daniel, Fajardo Val A, Yagita Hideo, Penninger Josef M, et al. Genetic deletion of muscle RANK or selective inhibition of RANKL is not as effective as full-length OPG-fc in mitigating muscular dystrophy. ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2018. 6

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MISC (633)：

Uchida Koichiro, Yin Enzhi, Fujimoto Keiichi, Bashuda Hisashi, Takeda Kazuyoshi, Mejima Mio, Yagita Hideo, Okumura Ko. Adoptive Transfer of HVEM signal induced Alloreacitve Regulatory T cell Protect Rejection in Allogeneic Murine Cardiac Transplantation Model. TRANSPLANTATION. 2018. 102. S732-S732
Takeda Ayaka, Taniguchi Hiroko, Kunishige Tomoyuki, Akiba Hisaya, Yagita Hideo, Hori Junko. Expression of T cell/transmembrane, immunoglobulin, and mucin (TIM)-4 in normal cornea and corneal grafts. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2018. 59. 9
野村莉紗, 鈴木仁美, Zhao Liang, 辻敦美, 金井克晃, 八木田秀雄, 森尾友宏, 金井正美, 鹿島田健一. 胎生期卵巣におけるNR5A1/Ad4BP/SF1の転写抑制はNotchシグナルを介した卵巣発生の最適化に必要である. 日本内分泌学会雑誌. 2018. 94. 1. 320-320
Tsukita Yoko, Okazaki Tatsuma, Sato Yasufumi, Yagita Hideo, Ichinose Masakazu. Sunitinib improves tumor microenvironment and augments the T cell infiltration and the effect of immunotherapy by DR-5. CANCER SCIENCE. 2018. 109. 120
Matsuoka Shuji, Mizutani Natsuko, Yagita Hideo, Takamatsu Hiroyuki, Hino Okio. Cell death of activated lymphocytes and lymphoma/leukemia cells induced by MHC class I and II mAb. (Anapocosis). CANCER SCIENCE. 2018. 109. 546

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Patents (28)：

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Works (2)：

NK細胞による腫瘍監視の分子機序
2001 - 2003
Molecular mechanisms that control NK cell-mediated tumor surveillance
2001 - 2003

Education (4)：

- 1985 Tohoku University
- 1985 Tohoku University Graduate School, Division of Pharmaceutical Sciences
- 1980 Tohoku University Faculty of Pharmaceutical Sciences
- 1980 Tohoku University Faculty of Pharmaceutical Science

Professional career (2)：

(BLANK) (Tohoku University)
(BLANK) (Tohoku University)

Work history (6)：

2014 - Juntendo University Faculty of Medicine
1987 - 1988 Juntendo University Faculty of Medicine
1987 - 1988 Assistant Professor,
1985 - 1987 Juntendo University Faculty of Medicine
1985 - 1987 Research Associate,

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Awards (3)：

2003 - ISI Highly Cited Researchers
2001 - Human Frontier Science Program Research Grant
2000 - 高松宮妃癌研究基金研究助成金

Association Membership(s) (3)：

日本がん免疫学会 , THE JAPANESE CANCER ASSOCIATION , THE JAPANESE SOCIETY FOR IMMUNOLOGY

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