Rchr
J-GLOBAL ID：200901017114107407   Update date: Aug. 27, 2024

Yamazaki Naoshi

ヤマザキ ナオシ | Yamazaki Naoshi
Affiliation and department：
Tokushima University Institute of Health Biosciences The University of Tokushima Graduate School

About Tokushima University Institute of Health Biosciences The University of Tokushima Graduate School


Other affiliations (2)：
Research field  (3)： Pharmaceuticals - health and biochemistry ,  Cell biology ,  Molecular biology
Research keywords  (2)： 生物系薬学 ,  Biopharmaceutics
Research theme for competitive and other funds  (14)：
  • 2016 - 2019 Use of modified U1 snRNA for rescue from exon skipping caused by 5' splice site mutation of human CTSA gene
  • 2011 - 2012 Development of a novel approach toward nucleic acids-based therapeutics
  • 2010 - 2012 Characterization of a novel protein which inhibits adipocytes differentiation
  • 2008 - 2009 腫瘍内微小環境変化を利用した新規DDSの開発
  • 2004 - 2005 脂肪細胞の分化を抑制する新規タンパク質の解析とこれを標的とした抗肥満戦略
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Papers (67)：
  • Toshihiko Tsutsumi, Satoshi Taira, Risa Matsuda, Chieko Kageyama, Mamiko Wada, Tomoya Kitayama, Norimitsu Morioka, Katsuya Morita, Kazuhito Tsuboi, Naoshi Yamazaki, et al. Lysophospholipase D activity on oral mucosa cells in whole mixed human saliva involves in production of bioactive lysophosphatidic acid from lysophosphatidylcholine. Prostaglandins & other lipid mediators. 2024. 106881-106881
  • Kiri Akieda, Kazuto Takegawa, Takeshi Ito, Gaku Nagayama, Naoshi Yamazaki, Yuka Nagasaki, Kohei Nishino, Hidetaka Kosako, Yasuo Shinohara. Unique Behavior of Bacterially Expressed Rat Carnitine Palmitoyltransferase 2 and Its Catalytic Activity. Biological and Pharmaceutical Bulletin. 2024. 47. 1. 23-27
  • Toshihiko Tsutsumi, Kohei Kawabata, Naoshi Yamazaki, Kenji Tsukigawa, Hiroyuki Nishi, Akira Tokumura. Extracellular and intracellular productions of lysophosphatidic acids and cyclic phosphatidic acids by lysophospholipase D from exogenously added lysophosphatidylcholines to cultured NRK52E cells. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2023. 1868. 9. 159349-159349
  • Kazuto Takegawa, Takeshi Ito, Atsushi Yamamoto, Naoshi Yamazaki, Mitsuru Shindo, Yasuo Shinohara. KH-17, a simplified derivative of bongkrekic acid, weakly inhibits the mitochondrial ADP/ATP carrier from both sides of the inner mitochondrial membrane. Chemical Biology & Drug Design. 2023. 101. 4. 865-872
  • Yoshinobu Fujiwara, Takeshi Ito, Atsumi Toiyama, Takenori Yamamoto, Naoshi Yamazaki, Mitsuru Shindo, Yasuo Shinohara. Suramin Inhibits Mitochondrial ADP/ATP Carrier, Not Only from the Cytosolic Side But Also from the Matrix Side, of the Mitochondrial Inner Membrane. BPB Reports. 2021. 4. 3. 92-97
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MISC (4)：
  • 木村 麻里安, 金澤 慶祐, 斎藤 朱里, 山崎 尚志, 池 啓伸, 伊藤 孝司, 南川 典昭, 滝口 祥令. 改変U1 snRNAを用いた変異カテプシンAスプライス異常の修復. 日本生化学会大会・日本分子生物学会年会合同大会講演要旨集. 2015. 88回・38回. [1P0762]-[1P0762]
  • 池 啓伸, 山崎 尚志, 田中 翔子, 金澤 慶祐, 滝口 祥令, 南川 典昭, 伊藤 孝司. 改変U1 snRNAによるヒトカテプシンAの遺伝子発現におけるスプライシング異常の修復. 日本生化学会大会プログラム・講演要旨集. 2014. 87回. [3P-362]
  • 大黒 多希子, 篠原 康雄, 島 厚志, 山崎 尚志, 寺田 弘. 褐色脂肪組織と白色脂肪組織におけるエネルギー代謝機構の相違. 日本分子生物学会年会プログラム・講演要旨集. 1996. 19. 263-263
  • ミトコンドリア輸送タンパクスーパーファミリー. 生体の科学. 1995. 46. 5.605
Patents (3)：
Lectures and oral presentations  (16)：
  • GDE7はリゾホスホリパーゼD型酵素としてN-アシルエタノールアミンとLPAを生成する
    (日本生化学会大会プログラム・講演要旨集 2016)
  • 口腔粘膜上皮細胞に存在する膜結合型リゾホスホリパーゼD
    (脂質生化学研究 2016)
  • 改変U1 snRNAを用いたヒトカテプシンAの遺伝子発現におけるスプライシング異常の是正
    (日本薬学会年会要旨集 2016)
  • Rescue of mutation-induced exon 7 skipping in human Cathepsin A by using modified U1 small nuclear RNA.
    (MOLECULAR BIOLOGY OF THE CELL 2016)
  • 改変型低分子RNAを用いたヒトカテプシンAの遺伝子発現におけるスプライシング異常の是正
    (日本生化学会大会(Web) 2015)
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Professional career (1)：
  • ph.D.
Association Membership(s) (2)：
日本生化学会 ,  日本薬学会
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